Review
Biotechnology & Applied Microbiology
Bruno Godinho, Nuno Gama, Artur Ferreira
Summary: Poly(glycerol sebacate) (PGS) is a biodegradable elastomer attracting attention in tissue engineering. New synthesis methods have been reported to reduce time and energy, and adjust properties for specific applications. This review compiles 20+ years of reports and proposes alternatives for faster production of PGS structures with desired properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Dongyong Sha, Zihan Wu, Jingjing Zhang, Yifan Ma, Zhaogang Yang, Yuan Yuan
Summary: In the past decade, PGS has gained significant attention in various biomedical fields due to its superior elasticity, biocompatibility, and biodegradability. To meet the increasing demands, different modification strategies and construction methods have been developed to expand the properties of PGS. Currently, PGS has been applied in areas such as hard tissue engineering, soft tissue engineering, drug delivery, and device design.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Florian Ruther, Judith A. Roether, Aldo R. Boccaccini
Summary: Due to the limited regenerative capacity of the natural human myocardium, 3D printing of PGS offers a promising alternative to produce scaffolds for cardiac tissue engineering. This study developed a PGS-zein-salt-based printing process with excellent printability and high shape fidelity.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Engineering, Biomedical
Hooman Golbaten-Mofrad, Mohammad Hadi Salehi, Seyed Hassan Jafari, Vahabodin Goodarzi, Maliheh Entezari, Mehrdad Hashemi
Summary: This study systematically investigates the influence of nanoclay and graphene oxide on the thermal, mechanical, hydrophobic, and biological properties of poly(glycerol sebacate)/gelatin nanocomposites. The results show that the appropriate dispersion of nanofillers improves the properties of the composites, but has a slight effect on mechanical properties. Additionally, the presence of nanofillers positively affects the biological performance of the composites.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Abdulraheem M. N. Atya, Atakan Tevlek, Muhannad Almemar, Dincer Gokcen, Halil Murat Aydin
Summary: Cardiovascular diseases are a leading cause of death worldwide, with limited treatment options for heart failure after myocardial infarction. This study introduced a novel electrically conductive elastomer-based composite for potential use as a cardiac patch in tissue engineering applications. The addition of electrically conductive carbon aerogels to the polymer matrix improved the mechanical and electrical properties of the obtained structures, making them suitable for myocardial tissue engineering.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Bruno Godinho, Rosana Nogueira, Nuno Gama, Artur Ferreira
Summary: In this study, poly-(glycerol-co-diacids) prepolymers were synthesized with different ratios of glycerol, sebacic acid, and succinic acid. The reaction time was found to be correlated with the ratio of diacids, with an increase in succinic acid leading to a decrease in reaction duration. Analysis using mass spectrometry and nuclear magnetic resonance revealed that the presence of succinic acid not only catalyzes the formation of poly-(glycerol)/ether bonds but also results in the growth of ester oligomers, the formation of cyclic structures, an increase in the number of oligomers detected, and a difference in mass distribution.
Article
Chemistry, Multidisciplinary
Bin Luo, Qiangqiang Zhou, Wenyi Chen, Lijie Sun, Lei Yang, Yifan Guo, Huijie Liu, Zekai Wu, Rasoul Esmaeely Neisiany, Xiaohong Qin, Jie Pan, Zhengwei You
Summary: In this study, we proposed a general strategy to facilitate tissue repair by modulating endogenous electric fields using nonadjacent wireless electrotherapy. We developed a 3D printed entirely soft and bioresorbable triboelectric nanogenerator-based stimulator which has biomimetic mechanical properties similar to those of soft tissue. The feasibility of constructing an electrical double layer with tissue for nonadjacent wireless electrotherapy was demonstrated and significant improvements in tissue repair were observed in the treated groups compared to the control group.
Article
Materials Science, Multidisciplinary
Mina Aleemardani, Louis Johnson, Michael Zivojin Trikic, Nicola Helen Green, Frederik Claeyssens
Summary: In this study, photocurable (PGS-co-PEG)-M copolymers were successfully prepared by methacrylation of PGS-co-PEG. The methacrylation process enhanced the mechanical strength of the copolymers while reducing their bioadhesive properties. These photocurable copolymers have great potential for biomedical applications.
MATERIALS TODAY ADVANCES
(2023)
Article
Materials Science, Biomaterials
Pardis Yousefi Talouki, Reyhaneh Tamimi, Soheila Zamanlui Benisi, Vahabodin Goodarzi, Shahrokh Shojaei, Saeed Hesami Tackalou, Hamid Reza Samadikhah
Summary: Elastomeric materials are valuable in meeting the needs of reconstructive medicine and tissue engineering. Poly glycerol sebacate (PGS) has shown potential in the medical industry, but it has poor mechanical properties. The use of composites and nanocomposites can improve the properties of PGS.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Review
Engineering, Biomedical
Lena Vogt, Florian Ruther, Sahar Salehi, Aldo R. Boccaccini
Summary: PGS is a promising material for biomedical applications due to its tunable properties through synthesis parameters and specific chemical modifications, allowing for a wide range of applications. Recent developments in PGS-based biomaterials have shown significant progress in tissue engineering, drug delivery, and wound healing.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Ruben Martin-Cabezuelo, Alicia Naderpour-Penalver, A. Sigen, Wenxin Wang, Guillermo Vilarino-Feltrer, Ana Valles-Lluch
Summary: Poly(glycerol sebacate) (PGS) is a hyperbranched polyester with tunable chemical and mechanical properties, along with biocompatibility and biodegradability. Understanding the synthesis parameters of PGS is crucial for controlling its synthesis and obtaining a scalable and reproducible final product. This study reveals the importance of hydroxyl affinity, water presence, and glycerol loss in determining the properties of the final PGS product.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Brandon B. Risley, Xiaochu Ding, Ying Chen, Paula G. Miller, Yadong Wang
Summary: PGS requires harsh thermal crosslinking conditions, while the addition of citric acid can enhance the mechanical properties by forming PGSC. It is found that low citrate content and short curing time can produce PGSC with good cytocompatibility, making it a potential candidate for biomedical applications.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kening Lang, Ha'Ani-Belle Quichocho, Sarah P. Black, Michael T. K. Bramson, Robert J. Linhardt, David T. Corr, Richard A. Gross
Summary: This study investigated the effects of different G/O ratios on the properties of PGOS copolymers prepared by enzymatic catalysis. The results showed that altering the G/O ratio could tune the molecular weight and mechanical properties of the copolymers. Additionally, increasing the content of 1,8-octanediol could slow down the degradation of the copolymers.
Article
Materials Science, Paper & Wood
Baoxiu Wang, Peng Ji, Yiding Ma, Jianchun Song, Zhengwei You, Shiyan Chen
Summary: A novel 3D cell culture system based on BC nanofibers and PGS was designed, mimicking the structure of natural ECM, promoting cell growth and cell morphology, and benefiting cellular adhesion and interaction. The reinforced PGS/BC cell culture has potential applications in cell culture or tissue engineering scaffold.
Article
Pharmacology & Pharmacy
Mohammad Foad Abazari, Shohreh Zare Karizi, Hadi Samadian, Navid Nasiri, Hassan Askari, Matin Asghari, Fateme Frootan, Hadi Bakhtiari, Hossein Mahboudi, Vahid Mansouri
Summary: This study demonstrated the potential application of fabricated PGS-PHB nanofibrous scaffold as a potential bone implant. Morphological study and cell experiments showed that the scaffold has a uniform surface and good biocompatibility. In the osteogenic differentiation process, the PGS-PHB scaffold exhibited promising supportive potential.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)