Review
Cardiac & Cardiovascular Systems
Christiana Lowis, Aurellia Ramara Winaya, Puja Kumari, Cristobal F. Rivera, John Vlahos, Rio Hermantara, Muhammad Yogi Pratama, Bhama Ramkhelawon
Summary: Cumulative evidence supports the idea that mechanical and frictional forces have distinct effects in the aortic layers and contribute to the development of abdominal aortic aneurysms (AAA). Mechanosensory cellular hubs play a crucial role in triggering signaling cascades that lead to the degradation of the extracellular matrix (ECM), resulting in aortic rupture. This review provides an overview of the current understanding of the mechanotransduction networks in different cell types during AAA development, focusing on the mechanosensors and stressors that accumulate in the AAA sac and their effects on inflammation, oxidative stress, remodeling, and ECM degradation. Manipulating this mechano-machinery could be a promising direction for future AAA research.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
David Sanchez-Infantes, Meritxell Nus, Miquel Navas-Madronal, Joan Fite, Belen Perez, Antonio J. Barros-Membrilla, Begona Soto, Jose Martinez-Gonzalez, Mercedes Camacho, Cristina Rodriguez, Ziad Mallat, Maria Galan
Summary: The study found extensive inflammatory infiltration in the aneurysmal wall, mainly composed of T cells, macrophages, and B cells, and altered levels of ROS, IgM, IgG, CD38, GDF15, S100A4, and CD36 in the plasma and aneurysmal tissue of AAA patients compared to controls. Circulating levels of IgG, CD38, and GDF15 were positively correlated with abdominal aortic diameter, and CD38 was correlated with PWS.
Article
Surgery
Muhammad Saad Hafeez, Shimena R. Li, Katherine M. Reitz, Amanda R. Phillips, Salim G. Habib, Antalya Jano, Yancheng Dai, Andre Stone, Edith Tzeng, Michel S. Makaroun, Nathan L. Liang
Summary: This study investigated the prevalence and characteristics of multiple organ failure (MOF) after repair of ruptured abdominal aortic aneurysm (rAAA). It found that MOF occurred in approximately 9-14% of patients within 3-5 days after the repair, and was associated with a three-fold increase in mortality. Endovascular repair was associated with a reduced incidence of MOF.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Hyangkyoung Kim, Sung-il Cho, Sungho Won, Youngjin Han, Tae-Won Kwon, Yong-Pil Cho, Ho Kim
Summary: The prevalence of cancer in AAA patients is significantly higher than in the control group, with a higher risk of developing cancer in AAA patients. The cancer-related death rate is significantly higher in AAA patients, indicating the need for appropriate screening for early detection of both diseases to improve long-term survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Acoustics
Wojciech Derwich, Tobias Keller, Natalie Filmann, Thomas Schmitz-Rixen, Christopher Blase, Kyriakos Oikonomou, Andreas Wittek
Summary: This study explores the use of four-dimensional ultrasound (4D US) in the prediction of abdominal aortic aneurysm (AAA) rupture. The results show that 4D US can detect and measure changes in wall strain in AAA patients, which are associated with the development and rupture risk of the aneurysm.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Azar Hosseini, Toktam Sahranavard, Zeljko Reiner, Tannaz Jamialahmadi, Yusra Al Dhaheri, Ali H. Eid, Amirhossein Sahebkar
Summary: This article reviews different studies and summarizes potential mechanisms by which statins can have an effect on abdominal aortic aneurysm (AAA). The evidence suggests an association between treatment with statins and improvement of AAA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Stanislav Polzer, Vojtech Man, Robert Vlachovsky, Lubos Kubicek, Jan Kracik, Robert Staffa, Tomas Novotny, Jiri Bursa, M. L. Raghavan
Summary: The study found that the strength in circumferential orientation of AAA wall tissue was significantly higher than in axial orientation, highlighting the importance of understanding the risk assessment of AAA rupture. This suggests that the orientation of tissue samples plays a crucial role in determining the failure properties of AAA tissue.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Construction & Building Technology
Yuan-Zuo Wang, Guo-Qiang Li, Yan-Bo Wang, Yi-Fan Lyu
Summary: The study investigates the influence of the initial geometry of the specimen and the plastic hardening property of materials on the necking process, and proposes a modified power law function to characterize the von Mises stress-strain curve on circumferentially notched specimens without measuring the instantaneous geometry of the cross-section.
JOURNAL OF CONSTRUCTIONAL STEEL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Azar Hosseini, Peter E. Penson, Arrigo F. G. Cicero, Jonathan Golledge, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: This review critically summarized prior research on the potential benefits of phytochemicals in preventing or treating AAA, with preliminary data supporting further investigation of certain phytochemicals as potential treatments for AAA.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Naofumi Amioka, Toru Miyoshi, Tomoko Yonezawa, Megumi Kondo, Satoshi Akagi, Masashi Yoshida, Yukihiro Saito, Kazufumi Nakamura, Hiroshi Ito
Summary: This study found that Pemafibrate has a preventive effect on AAA rupture, reducing ROS, inflammation, and extracellular matrix degradation. The protective effect against AAA rupture is partly mediated by the antioxidative effect of catalase induced by Pemafibrate.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Laura Lopez-Sanz, Susana Bernal, Luna Jimenez-Castilla, Ignacio Prieto, Sara La Manna, Sergio Gomez-Lopez, Luis Miguel Blanco-Colio, Jesus Egido, Jose Luis Martin-Ventura, Carmen Gomez-Guerrero
Summary: Research has shown that overexpression of FcγR has been detected in abdominal aortic aneurysm lesions, and inhibiting FcγR signaling molecules can reduce AAA development, restore inflammatory responses and vascular wall injury, potentially serving as therapeutic targets for AAA disease.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Surgery
Emily Y. Fan, Michael A. Buckner, Joseph LiCausi, Allison Crawford, Laura T. Boitano, Kimberly T. Malka, Andres Schanzer, Jessica P. Simons
Summary: Although the recommended size threshold for repairing abdominal aortic aneurysms (AAA) is 5.5 cm in men and 5.0 cm in women, repairs below these thresholds have been well-documented. This study aimed to characterize the indications for repairs below size recommendations at a single academic center and extrapolate these findings nationally.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Maraya Camazine, Jonathan Bath, Priyanka Singh, Robin L. Kruse, Todd R. Vogel
Summary: Failure to Rescue (FTR) is an important indicator of hospital care quality, and studying the risk factors associated with FTR in elective Abdominal Aortic Aneurysm (AAA) patients can help surgeons prevent operative mortality.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Javier Rodriguez-Carrio, Isabel Cerro-Pardo, Jes S. Lindholt, Elena Bonzon-Kulichenko, Diego Martinez-Lopez, Raquel Roldan-Montero, Joan-Carles Escola-Gil, Jean-Baptiste Michel, Luis Miguel Blanco-Colio, Jesus Vazquez, Ana Suraez, Jose Luis Martin-Ventura
Summary: The study found that oxidative modifications could lead to dysfunctional HDL in abdominal aortic aneurysm (AAA), and antibodies against HDL-MDA have the potential to be used as stable biomarkers of oxidative stress in AAA patients. These antibodies were detected in both a mouse model and AAA patients.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Medicine, General & Internal
Petroula Nana, Konstantinos Dakis, Alexandros Brodis, Konstantinos Spanos, George Kouvelos
Summary: A systematic review examined the correlation of abdominal aortic aneurysm expansion rates with serum circulating biomarkers, identifying specific biomarkers potentially useful for individualized surveillance of patients with increased AAA growth rates. Various biomarkers, including D-dimers, LDL-C, HDL-C, and genetic factors, were found to be significantly associated with AAA growth rates, suggesting a potential role for serum biomarkers in patient monitoring.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biophysics
K. Y. Volokh
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2015)
Article
Mechanics
Yoav Lev, Konstantin Y. Volokh
JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
(2016)
Article
Engineering, Biomedical
Konstantin Y. Volokh, Jacob Aboudi
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2016)
Article
Mechanics
K. Y. Volokh
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2017)
Article
Engineering, Mechanical
Viacheslav Slesarenko, Konstantin Y. Volokh, Jacob Aboudi, Stephan Rudykh
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2017)
Article
Mechanics
Anshul Faye, J. A. Rodriguez-Martinez, K. Y. Volokh
INTERNATIONAL JOURNAL OF NON-LINEAR MECHANICS
(2017)
Article
Biophysics
K. Y. Volokh
JOURNAL OF BIOMECHANICS
(2017)
Article
Materials Science, Multidisciplinary
D. Aranda-Iglesias, G. Vadillo, J. A. Rodriguez-Martinez, K. Y. Volokh
MECHANICS OF MATERIALS
(2017)
Article
Materials Science, Multidisciplinary
Y. Lev, A. Faye, K. Y. Volokh
EXPERIMENTAL MECHANICS
(2018)
Article
Mechanics
P. Mythravaruni, K. Y. Volokh
JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
(2018)
Article
Mechanics
K. Y. Volokh
Article
Materials Science, Multidisciplinary
Y. Lev, A. Faye, K. Y. Volokh
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2019)
Article
Mechanics
P. Mythravaruni, K. Y. Volokh
JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
(2019)
Proceedings Paper
Polymer Science
Y. Lev, K. Y. Volokh, A. Faye
CONSTITUTIVE MODELS FOR RUBBER XI
(2019)
Proceedings Paper
Polymer Science
A. Faye, Y. Lev, K. Y. Volokh
CONSTITUTIVE MODELS FOR RUBBER XI
(2019)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)