Journal
JOURNAL OF BIOMECHANICS
Volume 42, Issue 11, Pages 1650-1655Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2009.04.025
Keywords
Plaque; Atherothrombosis; Indentation; Modulus; Carotid artery
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Funding
- Cambridge-MIT Institute
- GlaxoSmithKline
- Medical Research Council [G0001237, G9439390, G0600986] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10327] Funding Source: researchfish
- MRC [G9439390, G0001237, G0600986] Funding Source: UKRI
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Eleven carotid atherothrombotic plaque samples were harvested from patients. Three samples that were highly calcified were discarded, while eight yielded results. The elastic properties of the material were estimated by fitting the measured indentation response to finite element simulations. The methodology was refined and its accuracy quantified using a synthetic rubber. The neo-Hookean form of the material model gave a good fit to the measured response of the tissue. The inferred shear modulus p was found to be in the range 7-100 kPa, with a median value of 11 kPa. A review of published materials data showed a wide range of material properties for human atherothrombotic tissue. The effects of anisotropy and time dependency in these published results were highlighted. The present measurements were comparable to the static radial compression tests of Lee et al, 1991 [Structure-dependent dynamic behaviour of fibrous caps from human atherosclerotic plaques. Circulation 83, 1764-1770]. (c) 2009 Elsevier Ltd. All rights reserved.
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