4.5 Article

Modelling adaptative volumetric finite growth in patient-specific residually stressed arteries

Journal

JOURNAL OF BIOMECHANICS
Volume 41, Issue 8, Pages 1773-1781

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2008.02.036

Keywords

residual stress; arterial growth; patient-specific geometry

Ask authors/readers for more resources

Understanding the functional performance of vascular tissue is taking a rising importance due to the increasing impact of cardiovascular diseases in developed countries. Currently available medical imaging acquisition techniques, combined with computer modelling allow patient-specific simulations of customized geometries that may help in medical diagnosis and therapeutic treatment. In this work we show methodology to develop patient-specific simulations. Particular features of arteries such as their multilayered structure, as well as the non-linear behaviour of the arterial tissue are considered. A strategy based on the decomposition of the deformation gradient tensor is followed in order to include residual stresses in the real geometry. By means of this technique, it is also possible to model the adaptative growth of the artery neglecting the developing process from the embryo state. (C) 2008 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Engineering, Chemical

Development and validation of a computational model for steak double-sided pan cooking

J. Moya, S. Lorente-Bailo, M. L. Salvador, A. Ferrer-Mairal, M. A. Martinez, B. Calvo, J. Grasa

Summary: The study developed and validated a numerical model to simulate the double-sided pan cooking of beef in a domestic setting. The model considers heat and moisture transfer, as well as meat deformation, successfully verifying experimental data of central temperature and weight loss during cooking. It accurately predicts cooking times for different steak thicknesses and is postulated as a useful tool for estimating optimal cooking time according to consumer preferences.

JOURNAL OF FOOD ENGINEERING (2021)

Article Engineering, Biomedical

Unraveling the multilayer mechanical response of aorta using layer-specific residual stresses and experimental properties

Clara Diaz, Juan A. Pena, Miguel A. Martinez, Estefania Pena

Summary: The study found that only an appropriate multilayer model that includes layer-specific residual stresses can accurately reproduce the mechanical response of the aorta, while a multilayer model without residual stresses is unable to fully capture the aorta's mechanical behavior.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2021)

Article Mathematics

Analysis of the Parametric Correlation in Mathematical Modeling of In Vitro Glioblastoma Evolution Using Copulas

Jacobo Ayensa-Jimenez, Marina Perez-Aliacar, Teodora Randelovic, Jose Antonio Sanz-Herrera, Mohamed H. Doweidar, Manuel Doblare

Summary: Modeling and simulation are essential for understanding complex biological processes like cancer evolution, but the resulting mathematical models often contain many nonlinear, difficult to estimate parameters requiring proper parametric analysis. Through copulas, we successfully addressed the issue of parameter correlation in experimental models and optimized experimental designs to reduce time and cost.

MATHEMATICS (2021)

Article Engineering, Multidisciplinary

Prediction and identification of physical systems by means of Physically-Guided Neural Networks with meaningful internal layers

Jacobo Ayensa-Jimenez, Mohamed H. Doweidar, Jose A. Sanz-Herrera, Manuel Doblare

Summary: In engineering and sciences, substituting data-driven predictions for well-grounded theoretical models is not straightforward due to the lack of data and the complexity of physical laws involved. The concept of Physically-Guided Neural Networks helps to predict input-output relations in physical systems while meeting physical constraints, accelerating training, reducing data requirements, filtering noise, and improving extrapolation capacity.

COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING (2021)

Article Biology

Predicting cell behaviour parameters from glioblastoma on a chip images. A deep learning approach

Marina Perez-Aliacar, Mohamed H. Doweidar, Manuel Doblare, Jacobo Ayensa-Jimenez

Summary: This study utilizes deep learning technology - Convolutional Neural Networks (CNN) to identify cell culture parameters from fluorescence images, predicting the behavior of glioblastoma (GBM). Through model training and experimental validation, the CNN demonstrates high accuracy and reliability in predicting parameters, laying the foundation for the development of future patient-specific tools.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

Article Food Science & Technology

Color changes in beef meat during pan cooking: kinetics, modeling and application to predict turn over time

Jara Moya, Silvia Lorente-Bailo, Ana Ferrer-Mairal, Miguel A. Martinez, Begona Calvo, Jorge Grasa, Maria L. Salvador

Summary: The kinetics of heat-induced color changes in beef meat were studied and implemented in a numerical model for double-sided pan cooking of steak. The CIELab color space was used to obtain lightness and reddish tone of the cooked meat. The model successfully verified experimental data for different cooking degrees and determined the optimum turn over time for achieving a similar color profile on both sides of the meat.

EUROPEAN FOOD RESEARCH AND TECHNOLOGY (2021)

Article Biotechnology & Applied Microbiology

Effects of the Haemodynamic Stimulus on the Location of Carotid Plaques Based on a Patient-Specific Mechanobiological Plaque Atheroma Formation Model

Patricia Hernandez-Lopez, Myriam Cilla, Miguel Martinez, Estefania Pena

Summary: This study presents a mechanobiological atheroma growth model modulated by a new haemodynamic stimulus, which showed improved prediction of plaques compared to traditional methods. However, there are cases where haemodynamics alone cannot accurately predict plaque locations, indicating the importance of other biological or genetic factors in atherosclerosis.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Article Mathematics

Methodology to Calibrate the Dissection Properties of Aorta Layers from Two Sets of Experimental Measurements

Itziar Rios-Ruiz, Myriam Cilla, Miguel A. Martinez, Estefania Pena

Summary: The study proposes a methodology for obtaining dissection parameters in aortic tissue through computational modelling, aiming to understand the mechanisms and progression of aortic dissection. By conducting two different experimental tests and calibrating the dissection properties of each interface, the study aims to contribute to the development of reliable numerical tools for simulating aortic dissection and aortic aneurysm rupture.

MATHEMATICS (2021)

Article Biophysics

Biomechanical characterization and constitutive modeling of the layer-dissected residual strains and mechanical properties of abdominal porcine aorta

Juan A. Pena, M. Cilla, Miguel A. Martinez, Estefania Pena

Summary: This study analyzes the residual stresses and mechanical properties of layer-dissected infrarenal abdominal aorta. The results show that the residual stresses are layer dependent, with the media layer being the softest and the intima and adventitia exhibiting considerable stiffness. The GOH model provides the best fitting to the experimental data.

JOURNAL OF BIOMECHANICS (2022)

Article Pharmacology & Pharmacy

Mathematical modelling of endovascular drug delivery: Balloons versus stents

Javier Escuer, Andre Fensterseifer Schmidt, Estefania Pena, Miguel A. Martinez, Sean McGinty

Summary: The most common treatment for obstructive coronary artery disease is the implantation of a permanent drug-eluting stent, but it has drawbacks such as delayed healing and challenges in treating re-narrowing. Drug-coated balloons provide a potential solution. This paper presents a computational model that compares drug delivery from drug-coated balloons and drug-eluting stents, and suggests the potential of designing drug-coated balloons with similar safety and efficacy to commercial drug-eluting stents.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Article Mathematics

A Combined Experimental-Numerical Investigation of the Thermal Efficiency of the Vessel in Domestic Induction Systems

Belen Bonet-Sanchez, Iulen Cabeza-Gil, Begona Calvo, Jorge Grasa, Carlos Franco, Sergio Llorente, Miguel A. Martinez

Summary: This study analyzes the influence of the vessel on thermal efficiency during the cooking process. By designing a numerical model and conducting experimental tests, it was found that thermal conductivity and the thermal contact between the vessel and the glass are the two most influential factors in the heating process. Cooking efficiency can be improved by using a vessel with low thermal conductivity and high concavity.

MATHEMATICS (2022)

Article Biophysics

Is location a significant parameter in the layer dependent dissection properties of the aorta?

Itziar Rios-Ruiz, Miguel Angel Martinez, Estefania Pena

Summary: Proper characterisation of biological tissue is crucial for understanding the impact of the biomechanical environment on the cardiovascular system. For aortic dissection, location and dissected layer play significant roles in its development and outcome. A study on healthy porcine aortas has revealed that dissection forces and requirements vary across different locations and layers, emphasizing the importance of characterising aortic tissue specifically.

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2022)

Meeting Abstract Cardiac & Cardiovascular Systems

Aortic stiffness descriptors by cardiac magnetic resonance are correlated with mechanical testing of ex-vivo aortic aneurysms specimens

Aroa Ruiz Munoz, Andrea Guala, Myriam Cilla, Miguel Martinez, Lydia Dux-Santoy, Gisela Teixido-Tura, Juan Garrido-Oliver, Laura Galian, Augusto Sao-Aviles, Arturo Evangelista, Ignacio Ferreira-Gonzalez, Estefania Pena, Jose Rodriguez-Palomares

CARDIOVASCULAR RESEARCH (2022)

Article Biology

A mechanobiological model for tumor spheroid evolution with application to glioblastoma: A continuum multiphysics approach

Ana Carrasco-Mantis, Teodora Randelovic, Hector Castro-Abril, Ignacio Ochoa, Manuel Doblare, Jose A. Sanz-Herrera

Summary: This study proposes a continuum mechanobiological model that explains the evolution process of tumor spheroids and reveals the relationship between cellular mechanical activity, nutrient consumption, and cell dynamics. Through validation experiments, the model is able to explain different outcomes, such as spheroid growth or shrinking, demonstrating the important role of mechanical interactions among cells in their evolution.

COMPUTERS IN BIOLOGY AND MEDICINE (2023)

Article Biochemistry & Molecular Biology

The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration

Hector Castro-Abril, Jonathan Heras, Jesus del Barrio, Laura Paz, Clara Alcaine, Marina Perez Aliacar, Diego Garzon-Alvarado, Manuel Doblare, Ignacio Ochoa

Summary: Mechanical interactions between cells and their microenvironment are crucial in determining cell fate, especially in the process of metastasis. Type I collagen hydrogels are commonly used to model the microenvironment in vitro due to their prevalence in the human body. This study analyzes the combined effects of hydrogel stiffness and ultrastructure on the migration patterns of colorectal cancer spheroids. Different types of collagen hydrogels are prepared with varying collagen concentration and gelation temperature, and their stiffness and ultrastructure are characterized. It is found that changes in these parameters result in differences in matrix stiffness and ultrastructural organization, which in turn influence the migration behavior of the spheroids.

MACROMOLECULAR BIOSCIENCE (2023)

Article Biophysics

Using bilateral data in controls and patients with bilateral and unilateral pathology requires increased scrutiny

Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan

Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.

JOURNAL OF BIOMECHANICS (2024)

Article Biophysics

Validation of a scanning technique with minimal compression for measuring muscle volume with freehand 3D ultrasound

J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez

Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.

JOURNAL OF BIOMECHANICS (2024)

Article Biophysics

Effect of personalized spinal profile on its biomechanical response in an EMG-assisted optimization musculoskeletal model of the trunk

C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl

Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.

JOURNAL OF BIOMECHANICS (2024)

Article Biophysics

Individuals with rotator cuff tears unsuccessfully treated with exercise therapy have less inferiorly oriented net muscle forces during scapular plane abduction

Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski

Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.

JOURNAL OF BIOMECHANICS (2024)

Article Biophysics

Hip and lumbosacral joint centre locations in asian population: Biases produced by existing regression equations and development of new equations

Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima

Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.

JOURNAL OF BIOMECHANICS (2024)

Article Biophysics

Differences in intra-foot movement strategies during locomotive tasks among chronic ankle instability, copers and healthy individuals

Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez

Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.

JOURNAL OF BIOMECHANICS (2024)

Article Biophysics

Acute effects of robot-assisted body weight unloading on biomechanical movement patterns during overground walking

Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller

Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.

JOURNAL OF BIOMECHANICS (2024)