Article
Chemistry, Medicinal
Eleonora Binatti, Gianni Zoccatelli, Francesca Zanoni, Giulia Dona, Federica Mainente, Roberto Chignola
Summary: The study demonstrates that astaxanthin-loaded microparticles are radiation-resistant, well-tolerated by J774A.1 macrophages, significantly reduce intracellular reactive oxygen species, and inhibit the release of active TGF beta. This indicates that micro-encapsulation of bioactive molecules is a promising strategy to specifically target phagocytic cells and modulate their functions.
Article
Immunology
Jingjing Zhang, Jinxin Qiu, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He, Ju Qiu, Lei Shen
Summary: This study identifies neuropilin-1 (Nrp1) as a tissue-specific marker of lung-resident ILC2s, which enhances their function and type 2 immune response by upregulating IL-33 receptor ST2 expression. Inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis.
Article
Biophysics
M. J. Feito, L. Casarrubios, M. Onaderra, M. Gomez-Duro, P. Arribas, A. Polo-Montalvo, M. Vallet-Regi, D. Arcos, M. T. Portoles
Summary: This study demonstrates that mesoporous bioactive glass and nanospheres do not have negative effects on the development and function of macrophages, and do not induce inflammatory response.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Immunology
Feixiang Duan, Xiaowu Wang, Hongwei Wang, Yongqiang Wang, Yan Zhang, Jiawei Chen, Xiandong Zhu, Bicheng Chen
Summary: This study found that GDF11 can improve SAP, reduce M1 macrophage polarization, and promote M2 macrophage polarization. GDF11 regulates macrophage polarization through the TGF beta R1/smad2 pathway. The findings of this study reveal the mechanism by which GDF11 regulates macrophage polarization in pancreatic tissues and highlights the protective role of GDF11 in SAP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Debora Denardin Luckemeyer, Wenrui Xie, Arthur Silveira Prudente, Katherine A. Qualls, Raquel Tonello, Judith A. Strong, Temugin Berta, Jun-Ming Zhang
Summary: Through experiments, researchers found that the TGF-beta signaling pathway plays an important role in local sympathetic blockade by regulating macrophages in the DRG and its anti-inflammatory actions to alleviate pain behaviors.
NEUROSCIENCE BULLETIN
(2023)
Article
Virology
Gabrielly Sbano Teixeira, Audrien Alves Andrade, Lauana Ribas Torres, Dinair Couto-Lima, Otacilio C. Moreira, Rayane Abreu, Mariana Caldas Waghabi, Elen Mello de Souza
Summary: The study found that TGF-beta 1 plays a significant role in the replication of dengue virus in macrophages, and targeting TGF-beta 1 may represent an alternative therapeutic strategy to be explored in dengue infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Layla Panahipour, Mariane Beatriz Sordi, Zahra Kargarpour, Reinhard Gruber
Summary: The study found that the TGF-beta activity in EMD mediates its anti-inflammatory effect in vitro. The anti-inflammatory activity of EMD was confirmed through a bioassay, and the presence of TGF-beta 1 in EMD was verified through immunoassay and cell experiments. Blocking the TGF-beta signaling pathway reversed the anti-inflammatory activity of EMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Lais Morandini, Derek Avery, Benjamin Angeles, Paul Winston, Rebecca K. Martin, Henry J. Donahue, Rene Olivares-Navarrete
Summary: Neutrophils play a crucial role in the immune response to biomaterial implantation by releasing cytokines, chemokines, and DNA-based networks called NETs. In this study, we found that inhibiting NET formation suppresses pro-inflammatory macrophage activation and accelerates the inflammatory phase of healing, leading to greater bone formation around the implanted biomaterial. These findings highlight the importance of the neutrophil response and innate immune cell regulation during the integration of biomaterials.
ACTA BIOMATERIALIA
(2023)
Article
Developmental Biology
Shunji Jia, Anming Meng
Summary: The TGF beta signaling family is evolutionarily conserved in metazoans and plays diverse roles in embryonic development, adult tissue homeostasis, and human diseases by regulating cell proliferation, differentiation, adhesion, migration, and apoptosis. The molecular mechanisms and key functions of TGF beta subfamily pathways in mesendoderm induction, dorsoventral patterning, laterality development, and tissue/organ formation have been extensively investigated.
Article
Multidisciplinary Sciences
Lizhong Liu, Anastasiia Nemashkalo, Luisa Rezende, Ji Yoon Jung, Sapna Chhabra, M. Cecilia Guerra, Idse Heemskerk, Aryeh Warmflash
Summary: This study visualizes the activity of endogenous Nodal protein in living cells using a human gastruloid model and reveals that Nodal activity spreads through a relay mechanism, with timing controlled by the Nodal inhibitor Lefty. This study provides insights into how morphogen gradients are formed and interpreted during mammalian embryogenesis.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Yicheng Wei, Jialuo Cai, Ruiqiu Zhu, Ke Xu, Hongchang Li, Jianxin Li
Summary: This review focuses on the role of TRPA1 channel in fibroblasts, exploring its interactions with inflammatory factors and its different functions in the fibrosis process in different organs. The aim of this review is to describe the function of TRP channels in controlling fibrosis through fibroblasts in various inflammatory and immune-mediated diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maurizio Federico
Summary: COVID-19 pathogenesis develops in two phases. mRNA vaccines have shown efficacy in containing the development of severe disease possibly by inhibiting alveolar macrophages and counteracting cytokine storm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xi Li, Xinwen Li, Wenhao Li, Yingqing Zhang, Haiyan Guo, Guangxing Wang, Yayuan Li, Xiaowen Wu, Ruiqin Hu, Siyu Wang, Xiaomiao Zhao, Liangbiao Chen, Guijun Guan
Summary: The study reveals the important role of gsdf in meiotic entry in medaka by analyzing gametogenesis in gsdf-deficient gonads. The deficiency of gsdf leads to abnormal expression of genes like Sycp3, causing disruption of normal gametogenesis processes. This finding is supported by immunofluorescence analysis and transmission electron microscope observations.
Article
Chemistry, Multidisciplinary
Min-xiu Wang, Wu Luo, Lin Ye, Lei-ming Jin, Bin Yang, Qian-hui Zhang, Jian-chang Qian, Yi Wang, Yi Zhang, Guang Liang
Summary: This study investigates the role of Dectin-1 in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The researchers found that Dectin-1 expression was significantly elevated in liver tissues of patients with NAFLD. They also showed that Dectin-1 plays a deleterious role in NAFLD through enhancing macrophage pro-inflammatory responses.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Pharmacology & Pharmacy
Yonghui Zou, Yi Xu, Xiaofeng Chen, Yaoqi Wu, Longsheng Fu, Yanni Lv
Summary: LRG1 is an important protein involved in normal physiological activities of the nervous system and has been found to affect the development of various diseases. However, research on its role in disease is still in its early stages, and further studies are needed to uncover its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Svetlana Fa, Trine Vilsboll Larsen, Katrine Bilde, Tina F. Daugaard, Emil H. Ernst, Karin Lykke-Hartmann, Rasmus H. Olesen, Linn S. Mamsen, Erik Ernst, Agnete Larsen, Anders L. Nielsen
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Orthopedics
Mette H. Hjorth, Inger Mechlenburg, Kjeld Soballe, Stig S. Jakobsen, Lone Roemer, Maiken Stilling
JOURNAL OF ARTHROPLASTY
(2018)
Article
Integrative & Complementary Medicine
Tabia Volqvartz, Anna Louise Vestergaard, Sissel Kramer Aagaard, Mette Findal Andreasen, Iana Lesnikova, Niels Uldbjerg, Agnete Larsen, Pinar Bor
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Nutrition & Dietetics
Bettina Ewers, Ellen Trolle, Sabine Schade Jacobsen, Dorte Vististen, Thomas Peter Almdal, Tina Vilsboll, Jens Meldgaard Bruun
Article
Orthopedics
Julie Sandell Jacobsen, Kjeld Soballe, Kristian Thorborg, Lars Bolvig, Stig Storgaard Jakobsen, Per Holmich, Inger Mechlenburg
Article
Multidisciplinary Sciences
Jordi Guiu, Edouard Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko, Martti Maimets, Anne Jorgensen, Signe Perlman, Lene Lundvall, Linn Salto Mamsen, Agnete Larsen, Rasmus H. Olesen, Claus Yding Andersen, Lea Langhoff Thuesen, Kristine Juul Hare, Tune H. Pers, Konstantin Khodosevich, Benjamin D. Simons, Kim B. Jensen
Article
Multidisciplinary Sciences
Trine Maxel, Kamille Smidt, Charlotte C. Petersen, Bent Honore, Anne K. Christensen, Per B. Jeppesen, Birgitte Brock, Jorgen Rungby, Johan Palmfeldt, Agnete Larsen
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Henrik Thyge Corfitsen, Betina Krantz, Agnete Larsen, Antonio Drago
ACTA NEUROPSYCHIATRICA
(2020)
Article
Orthopedics
Peter Bo Jorgensen, Henrik Daugaard, Stig Storgaard Jakobsen, Martin Lamm, Kjeld Soballe, Maiken Stilling
Article
Obstetrics & Gynecology
Katrine Bilde, Rasmus H. Olesen, Emil H. Ernst, Linn S. Mamsen, Mahboobeh Amoushahi, Karin Lykke-Hartmann, Erik Ernst, Agnete Larsen
HUMAN REPRODUCTION
(2019)
Article
Orthopedics
Josefine Beck Larsen, Inger Mechlenburg, Stig Storgaard Jakobsen, Theis Munchholm Thilleman, Kjeld Soballe
Article
Pharmacology & Pharmacy
Tabia Volqvartz, Anna Louise Vestergaard, Sissel K. Aagaard, Mette F. Andreasen, Iana Lesnikova, Niels Uldbjerg, Agnete Larsen, Pinar Bor
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2020)
Review
Obstetrics & Gynecology
Nicolai B. Jensen, Signe D. Justesen, Agnete Larsen, Erik Ernst, Lars H. Pedersen
Summary: Immunosuppressant drug MTX shows transient spermatotoxic and genotoxic potentials in human and animal studies, affecting sperm quality parameters but returning to reference values within a few months. Data on GCV and MMF are limited and inconclusive, hence their spermatotoxic and genotoxic potentials cannot be ruled out.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Orthopedics
Josephine Olsen Kipp, Martin Lamm, Kjeld Soballe, Stig Storgaard Jakobsen
JOURNAL OF ORTHOPAEDICS
(2020)
Article
Multidisciplinary Sciences
B. Ewers, E. Trolle, S. S. Jacobsen, D. Vististen, T. P. Almdal, T. Vilsboll, J. M. Bruun
Article
Engineering, Biomedical
Mehlika Karamanlioglu, Serap Yesilkir-Baydar
Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata
Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi
Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng
Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)