Review
Pharmacology & Pharmacy
Edward J. Calabrese
Summary: This paper provides a detailed assessment of hormetic dose responses in adipose-derived stem cells (ADSCs) of animal models and humans, showing that hormetic dose responses are commonly reported for ADSCs and may have a determinant role in potential clinical applications.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Tihomir Georgiev-Hristov, Mariano Garcia-Arranz, Jacobo Trebol-Lopez, Paula Barba-Recreo, Damian Garcia-Olmo
Summary: Adipose-derived stem cells have clinically beneficial qualities and have been investigated in basic research and clinical studies. Allogeneic adipose-derived stem cells have recently been approved for treating complex perianal fistulas in adults with Crohn's disease. The current understanding of adipose stem cell harvest includes quantitative and qualitative differences that may be influenced by donor conditions and sites. This review summarizes the current knowledge on the topic and proposes optimal donor profiles for further applications and studies.
Article
Biochemistry & Molecular Biology
Junbiao Fang, Ruijie Lu, Yujie Lin, Hongfa Wang, Hanwei Wei, Junkai Wang, Qiaoyan Liu, Huizi Liu, Zhenfeng Zhou, Ling Zhang, Ruolang Pan, Yue Chen
Summary: In this study, sepsis serum was used to mimic microenvironmental effects and it was found that sepsis serum can enhance the secretion of cytokines and growth factors, as well as the migration capacity, of adipose tissue-derived stem cells (ADSCs). The metabolic pattern of these cells was also reprogrammed, leading to increased osteoblastic differentiation capacity and decreased adipogenesis and chondrogenesis. These findings reveal that the septic microenvironment can regulate the fate of ADSCs.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Medicine, Research & Experimental
Francesca Toia, Elena Lo Presti, Anna Barbara Di Stefano, Marta Di Simone, Marco Trapani, Anna Maria Corsale, Carmela Picone, Francesco Moschella, Francesco Dieli, Adriana Cordova, Serena Meraviglia
Summary: This study analysed the immunomodulatory properties of spheroids from adipose stem cells (SASCs) and compared them to adipose stem cells (ADSCs). SASCs showed stronger immunomodulatory abilities in heterologous experimental settings compared to ADSCs. SASCs also demonstrated greater anti-inflammatory properties.
Editorial Material
Cell Biology
Bruce A. Bunnell
Summary: This article discusses the importance and potential clinical applications of stem cells within adipose tissue, which are multipotent and secrete various cytokines.
Article
Multidisciplinary Sciences
Ban Al-kurdi, Nidaa A. Ababneh, Nizar Abuharfeil, Saddam Al Demour, Abdalla S. Awidi
Summary: This study evaluated the effects of different culture media and serum types on the differentiation of human adipose-derived stem cells (ADSCs) into urothelial-like cells. Results showed that using CM supplemented with FBS led to the highest expression levels of urothelial cell markers. High concentrations of pHPL reduced the efficiency of ADSCs differentiation, while EGF, VEGF, and PDGF were implicated in the mechanism of urothelial cell differentiation.
Review
Emergency Medicine
Xin Yuan, Li Li, Haofan Liu, Jing Luo, Yongchao Zhao, Cheng Pan, Xue Zhang, Yuwen Chen, Maling Gou
Summary: This article reviews emerging strategies to improve the therapeutic efficacy of adipose-derived stem cells (ADSCs) in tissue regeneration. These strategies include advanced cell expansion technologies, enhancing regenerative functions of ADSCs, and improving cell delivery efficiency. Critical issues about the sources, effectiveness, and safety of ADSCs are also pointed out.
Article
Cell Biology
Xiaoyun Wu, Yongxu Mu, Jingyi Yao, Fuhong Lin, Daocheng Wu, Zhijie Ma
Summary: The study revealed that ADSCs from UC patients exhibited defective immunosuppression, indicating their unsuitability for autologous transplantation in treating UC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna Trzyna, Agnieszka Banas-Zabczyk
Summary: The secretome of ASCs, including exosomes, contains a variety of cytokines and non-coding RNAs that have therapeutic potential in a wide range of diseases. Utilizing ASC secretome as a cell-free therapy shows promise in overcoming limitations of cell-based therapies and improving treatment efficacy.
Article
Biotechnology & Applied Microbiology
Luminita Labusca, Dumitru-Daniel Herea, Anca Emanuela Minuti, Cristina Stavila, Camelia Danceanu, Petru Plamadeala, Horia Chiriac, Nicoleta Lupu
Summary: Iron oxide based magnetic nanoparticles (MNP) have versatile applications in biology and medicine. This study compared the chondrogenic conversion of ADSC-MNP and WJMSC under different conditions, finding that ADSC-MNP displayed superior proliferation and chondrogenic potential, with MF exposure further enhancing chondrogenesis in ADSC-MNP. Loading ADSC with MNP may be a promising approach for cartilage engineering in the future.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Chunhui Sheng, Xiaodong Guo, Zhuqing Wan, Xiaoqiang Bai, Hao Liu, Xiao Zhang, Ping Zhang, Yunsong Liu, Wenyue Li, Yongsheng Zhou, Longwei Lv
Summary: This study investigated the potential of exosomes derived from human adipose-derived stem cells (hASCs) in promoting osteogenic differentiation for osteoporosis treatment. The study identified the key differentially expressed microRNA between two exosomes and their potential target gene. Results showed that exosomes from osteogenic induction medium had a better effect on promoting osteogenic differentiation than those from proliferation medium. Moreover, miR-335-3p inhibitor-optimized exosomes enhanced osteogenic differentiation in vitro and bone density in vivo, suggesting the potential of engineered exosomes in optimizing exosome-based therapy for osteoporosis.
Article
Biochemistry & Molecular Biology
Mengzhu Lv, Simeng Zhang, Bo Jiang, Sunrun Cao, Yuqing Dong, Liu Cao, Shu Guo
Summary: The study demonstrated that adipose-derived stem cell therapy can delay replicative senescence and shift metabolic homeostasis, ultimately delaying the aging process by promoting mitophagy and improving mitochondrial quality in cells. The research also showed that ADSC therapy can improve aging-related symptoms and phenotypes through mitochondrial quality control, offering significant potential for future applications in aging-related diseases.
Article
Cell & Tissue Engineering
Junling Gao, Juntao Yuan, Qun Liu, Yuanli Wang, Huiwen Wang, Yingjie Chen, Wenjun Ding, Guangju Ji, Zhongbing Lu
Summary: The research found that ADSCs can protect against the adverse health effects of PM2.5 exposure by attenuating pulmonary inflammation and cell death. This suggests that ADSC transplantation may be a potential therapeutic approach for severe air pollution-associated diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Ziwan Ji, Zhongming Cai, Shuming Gu, Yucang He, Zikai Zhang, Tian Li, Qing Wei, Jingping Wang, Chen Ke, Liqun Li
Summary: The study found that adipose-derived exosomes (ADEs) can inhibit adipogenic differentiation of adipose-derived stem cells by activating the Hedgehog (Hh) signaling pathway, thereby reducing the adverse effects of obesity on wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Gen Li, Yin Zhang, Jiezhou Wu, Renhao Yang, Qi Sun, Yidong Xu, Bo Wang, Ming Cai, Yang Xu, Chengyu Zhuang, Lei Wang
Summary: This study explores the effects and mechanism of adipose stem cells-derived exosomes (ADSCs-Exos) and ADSCs-Exos modified tissue engineering scaffold on bone defect repair. The results demonstrate that ADSCs-Exos promote the proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and ADSCs-Exos modified scaffold enhances the repair of BMSCs and bone defects both in vitro and in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biology
Miguel A. Gutierrez-Monreal, Victor Trevino, Jorge E. Moreno-Cuevas, Sean-Patrick Scott
CHRONOBIOLOGY INTERNATIONAL
(2016)
Article
Biochemical Research Methods
Raul Aguirre-Gamboa, Emmanuel Martinez-Ledesma, Hugo Gomez-Rueda, Rebeca Palacios, Isabel Fuentes-Hernandez, Emilio Sanchez-Canales, Rafael Chacolla-Huaringa, Servando Cardona-Huerta, Luis Villela, Sean-Patrick Scott, Jose Tamez-Pena, Victor Trevino
CURRENT BIOINFORMATICS
(2016)
Article
Biochemistry & Molecular Biology
Rafael Chacolla-Huaringa, Jorge Moreno-Cuevas, Victor Trevino, Sean-Patrick Scott
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Automation & Control Systems
Yocanxochitl Perfecto-Avalos, Raquel Cuevas-Diaz Duran, Luis Villela, Alejandro Garcia-Gonzalez, Ricardo Javier Diaz-Dominguez, Tania Loyo, Miguel Angel Gutierrez-Monreal, Juan Manuel Esparza-Trevino, Carlos Rocha-Inclan, Rocio Rojo, Eduardo Cardenas-Cantu, Jezreel Pantaleon-Garcia, Sean-Patrick Scott
JOURNAL OF CHEMOMETRICS
(2018)
Article
Neurosciences
Raul Aguilar-Roblero, Adriana Mejia-Lopez, Dominique Cortes-Pedroza, Jose L. Chavez-Juarez, Miguel A. Gutierrez-Monreal, Gabriela Dominguez, Paula Vergara, Jose Segovia
Article
Medicine, General & Internal
Ulises Aregueta-Robles, Oscar R. Fajardo-Ramirez, Luis Villela, Janet A. Gutierrez-Uribe, Jose Hernandez-Hernandez, Rosa del Carmen Lopez-Sanchez, Sean-Patrick Scott, Sergio Serna-Saldivar
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION
(2018)
Article
Biology
Erin E. Terry, Xiping Zhang, Christy Hoffmann, Laura D. Hughes, Scott A. Lewis, Jiajia Li, Matthew J. Wallace, Lance A. Riley, Collin M. Douglas, Miguel A. Gutierrez-Monreal, Nicholas F. Lahens, Ming C. Gong, Francisco Andrade, Karyn A. Esser, Michael E. Hughes
Article
Biology
Brian A. Hodge, Xiping Zhang, Miguel A. Gutierrez-Monreal, Yi Cao, David W. Hammers, Zizhen Yao, Christopher A. Wolff, Ping Du, Denise Kemler, Andrew R. Judge, Karyn A. Esser
Article
Medicine, Research & Experimental
Yocanxochitl Perfecto-Avalos, Alejandro Garcia-Gonzalez, Ana Hernandez-Reynoso, Gildardo Sanchez-Ante, Carlos Ortiz-Hidalgo, Sean-Patrick Scott, Rita Q. Fuentes-Aguilar, Ricardo Diaz-Dominguez, Grettel Leon-Martinez, Veronica Velasco-Vales, Mara A. Cardenas-Escudero, Jose A. Hernandez-Hernandez, Arturo Santos, Jose R. Borbolla-Escoboza, Luis Villela
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Review
Endocrinology & Metabolism
Miguel A. Gutierrez-Monreal, Jan-Frieder Harmsen, Patrick Schrauwen, Karyn A. Esser
Article
Biochemistry & Molecular Biology
Gene Ryan Crislip, Stephanie E. Wohlgemuth, Christopher A. Wolff, Miguel A. Gutierrez-Monreal, Collin M. Douglas, Elnaz Ebrahimi, Kit-Yan Cheng, Sarah H. Masten, Dominique Barral, Andrew J. Bryant, Karyn A. Esser, Michelle L. Gumz
Summary: The study found that iMS-BMAL1 KO mice exhibited an aging phenotype with no renal phenotype, and their response to low potassium diet and phase advance in renal function was similar to the control group, indicating that disruption of the clock in skeletal muscle does not lead to significant renal injury.
Article
Cell Biology
Christopher A. Wolff, Miguel A. Gutierrez-Monreal, Lingsong Meng, Xiping Zhang, Lauren G. Douma, Hannah M. Costello, Collin M. Douglas, Elnaz Ebrahimi, Ann Pham, Aline C. Oliveira, Chunhua Fu, Amy Nguyen, Bryan R. Alava, Stuart J. Hesketh, Andrew R. Morris, Mehari M. Endale, G. Ryan Crislip, Kit-yan Cheng, Elizabeth A. Schroder, Brian P. Delisle, Andrew J. Bryant, Michelle L. Gumz, Zhiguang Huo, Andrew C. Liu, Karyn A. Esser
Summary: Cellular circadian clocks regulate daily transcriptional program and are important for maintaining homeostasis and resilience. Age-related changes in circadian functions have been observed. This study characterized age-dependent changes in the circadian transcriptome in multiple tissues, revealing tissue-specific alterations in clock output and decreased number of rhythmically expressed genes (REGs) with aging. Analysis of differentially expressed genes (DEGs) at different times of day identified distinct gene expression patterns, with increased variability in aged tissues. This study expands our understanding of aging and highlights the impact of aging on circadian clock function and temporal gene expression changes.
Article
Physiology
G. Ryan Crislip, Jermaine G. Johnston, Lauren G. Douma, Hannah M. Costello, Alexandria Juffre, Kyla Boyd, Wendy Li, Cheoting C. Maugans, Miguel Gutierrez-Monreal, Karyn A. Esser, Andrew J. Bryant, Andrew C. Liu, Michelle L. Gumz
Summary: This article reviews the impact of circadian rhythms on physiological function in humans and discusses findings from cell and rodent models.
COMPREHENSIVE PHYSIOLOGY
(2022)