Article
Cardiac & Cardiovascular Systems
Arafat Yildirim, Mehmet Kucukosmanoglu, Nermin Yildiz Koyunsever, Yusuf Cekici, Mustafa Dogdus, Erhan Saracoglu, Salih Kilic
Summary: In this study, we found that SCUBE1 levels are an independent predictor of high thrombus burden in patients with STEMI.
Article
Geriatrics & Gerontology
Mei Yang, Yi Liu, Yuxia Ma, Wenhao Wang
Summary: Acute pulmonary thromboembolism (APTE) is a serious condition with high mortality and complex symptoms. Early diagnosis and prognostic assessment of APTE are important for the long-term benefits of patients, especially elderly patients. This study included elderly patients with pulmonary embolism and found that high plasma D-dimer, plasma SCUBE1, and right ventricular Tei index were risk factors for poor prognosis after treatment. Additionally, the combined detection of these factors improved the prediction sensitivity and specificity.
REJUVENATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Junki Hirano, Sachiyo Yoshio, Yusuke Sakai, Li Songling, Tatsuya Suzuki, Yumi Itoh, He Zhang, David Virya Chen, Saori Haga, Hiroko Oomori, Takahiro Kodama, Yusuke Maeda, Yoshihiro Ono, Yu Takahashi, Daron M. Standley, Masahiro Yamamoto, Kohji Moriishi, Kyoji Moriya, Tatsuya Kanto, Tetsuo Takehara, Kazuhiko Koike, Yoshiharu Matsuura, Toru Okamoto
Summary: Immunoevasins such as the HCV core protein interfere with the maturation and expression of MHC class I molecules, impairing antigen presentation to CD8(+) T cells and evading immune recognition. Targeting the signal peptide peptidase (SPP) may represent a potential strategy to impair MHC class I molecules by both DNA and RNA viruses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Ozkan Cesur, Tugba Endogan Tanir, Pinar Celepli, Fatma Ozarslan, Sema Hucumenoglu, Adnan Karaibrahimoglu, Nesrin Hasirci
Summary: The study aimed to prepare a bioactive and biodegradable bilayer mesh using FGF-loaded gelatin and PCL films for esophageal anastomosis treatment. Results showed that the FGF-loaded mesh improved tissue healing and repair of the esophageal defects.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Han Wang, Huan Qi, Hui Zhang, Shao-Yong Zhang, Cheng-Hong Zhang, Li -Qin Zhang, Wen-Sheng Xiang, Ji-Dong Wang
Summary: Bioinformatics analysis and HPLC-DAD analysis of a whole genome sequence revealed the ability of Streptomyces sp. Hu103 to produce skyllamycin analogues. Chemical investigation of this strain led to the discovery of four new cinnamoyl-containing cyclo-peptides, anulamycins A-D (1-4), two new cinnamoyl-containing linear peptides, anulamycins E and F (5 and 6), and two known cyclopeptides, skyllamycins A (7) and B (8). Their structures and absolute configurations were determined by detailed analysis of NMR and HRESIMS/MS spectroscopic data and the advanced Marfey's method. Compounds 1-4 exhibited antibacterial activity comparable to skyllamycins A and B.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Dries Smets, Alexandra Tsirigotaki, Jochem H. Smit, Srinath Krishnamurthy, Athina G. Portaliou, Anastassia Vorobieva, Wim Vranken, Spyridoula Karamanou, Anastassios Economou
Summary: This study investigates the delayed folding mechanism and the regulatory role of signal peptides in the Sec pathway. By comparing two homologous proteins, PpiA and PpiB, it is found that PpiA folds slower and the folding process involves hierarchical foldons. The folding of PpiA is delayed by less hydrophobic native contacts, frustrated residues, and a beta-turn in the earliest foldon, as well as by signal peptide-mediated disruption of foldon hierarchy. Additionally, grafting selected residues or the signal peptide of PpiA onto PpiB converts it into a slow folder with enhanced in vivo secretion. These structural adaptations facilitate protein trafficking.
Article
Plant Sciences
Syed Muhammad Muntazir Mehdi, Michal Wojciech Szczesniak, Agnieszka Ludwikow
Summary: Abscisic acid (ABA) affects plant physiology by regulating gene expression. The AtBro1 gene plays a crucial role in the plant's response to abiotic stress, such as drought and salt stress. ABA stimulates stress-resistance responses through the activation of AtBro1.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Cell Biology
Bo Huang, Yiren Jiao, Yifan Zhu, Zuocheng Ning, Zijian Ye, Qing X. Li, Chingyuan Hu, Chong Wang
Summary: The study found that Mdfi promotes the differentiation of C2C12 cells and positively modulates muscle fiber transformation. Further analysis revealed that the positive regulatory effect of Mdfi is achieved through the modulation of specific genes and signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
WANG Jian-xia, LONG Feng, ZHU Hang, ZHANG Yan, WU Jian-ying, SHEN Shen, DONG Jin-gao, HAO Zhi-min
Summary: The study identified 13 members of the S. turcica CFEM protein family, with StCFEM12 identified as a candidate effector. This study laid the foundation for illustrating the roles of CFEM proteins during the pathogenic processes of phytopathogens.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Optics
Zhennan Zheng, Zhonghan Su, Xinlu Gao, Guanjun Gao, Jingcan Ma, Jiasi Yang, Chunsheng Li, Shanguo Huang, Hongfei Liu
Summary: The study introduces a new phase drift compensation scheme, utilizing data-aided channel equalization to accurately recover astronomical signal channels while compensating for phase drifts and broadband transmission link distortions. The proposed scheme features a simple transmission structure, modularized function parts, and high accuracy in astronomical signal channel estimation as demonstrated in proof-of-concept experiments.
Article
Oncology
Eric G. Schmuck, Sushmita Roy, Anisa Dhillon, Sydney Walker, Keith Spinali, Sophia Colevas, Tianhua Zhou, Gagan Chhabra, Yuming Liu, Abdul Kader Sagar, Charlie J. Childs, John A. Kink, Kevin W. Eliceiri, Peiman Hematti, Amish N. Raval
Summary: Cardiac fibroblasts and myofibroblasts play crucial roles in assembling and maintaining extracellular matrix. By culturing these cells, a bioengineered matrix with therapeutic potential can be produced. The identification of Sushi Containing Domain 2 (SUSD2) as a novel marker for cultured human cardiac fibroblasts and myofibroblasts provides a promising avenue for further research and quality control in matrix investigations.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ying Huang, Kai-min Hui, Qian Ren
Summary: A CUB domain-containing protein HcCDCP was cloned and characterized from freshwater pearl mussel. Tissue distribution analysis showed that HcCDCP was expressed in all tissues, with the highest expression in hepatopancreas.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Food Science & Technology
Karen Brami-Cherrier, Alex Chernavsky, Hui You, Sergei A. Grando, Amy Brideau-Andersen, Birgitte Sondergaard
Summary: Studies have shown that commercial preparations of botulinum neurotoxin type A can reduce sebum production and improve oily skin and large pores. This study further investigated the direct effect of botulinum neurotoxin type A on sebocyte lipogenesis using an in vitro model. The results suggest that picomolar concentrations of botulinum neurotoxin type A can modulate sebocyte lipogenesis and reduce oleic acid-induced sebocyte differentiation.
Article
Microbiology
Ni Cai, Rong Liu, Duozi Yan, Neng Zhang, Kaihui Zhu, Daogang Zhang, Xiangqun Nong, Xiongbing Tu, Zehua Zhang, Guangjun Wang
Summary: In this study, 13 CFEM genes from the entomopathogen Metarhizium anisopliae were cloned and identified. These genes were analyzed for their sequence features, phylogenetic relationships, and expression patterns. The study found that six potential effector proteins with varying structures and subcellular localizations in host cells may play important roles in the interaction between M. anisopliae and plants.
Article
Immunology
Ji Woong Kim, Hyun Jung Kim, Kyun Heo, Yoonwoo Lee, Hui Jeong Jang, Ho-Young Lee, Jun Won Park, Yea Bin Cho, Ji Hyun Lee, Ha Gyeong Shin, Ha Rim Yang, Hye Lim Choi, Hyun Bo Shim, Sukmook Lee
Summary: This study presents a novel dual-targeting strategy using bispecific antibodies (bsAbs) that specifically recognize both the SARS-CoV-2 receptor-binding domain (RBD) and fusion peptide (FP), crucial domains for viral attachment and fusion. The bsAb demonstrated higher neutralization efficacy against SARS-CoV-2 variants compared to the parental RBD-specific monoclonal antibody (mAb). This finding provides a potential approach for rapid development and management against evolving SARS-CoV-2 variants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Musin Kelel, Ruey-Bing Yang, Tsen-Fang Tsai, Pi-Hui Liang, Fu-Yu Wu, Yu-Tien Huang, Ming-Fong Yang, Yu-Ping Hsiao, Li-Fang Wang, Chen-Fen Tu, Fu-Tong Liu, Yungling L. Lee
Summary: The study reveals that FUT8 remodeling of EGFR plays a critical role in the development of psoriasis phenotypes and is associated with disease severity. FUT8 gain of function promotes cell proliferation, while short hairpin FUT8 reduces proliferation and alters the cell cycle.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Genetics & Heredity
Yuh-Charn Lin, Marcello Niceta, Valentina Muto, Barbara Vona, Alistair T. Pagnamenta, Reza Maroofian, Christian Beetz, Hermine van Duyvenvoorde, Maria Lisa Dentici, Peter Lauffer, Sadeq Vallian, Andrea Ciolfi, Simone Pizzi, Peter Bauer, Nana-Maria Gruening, Emanuele Bellacchio, Andrea Del Fattore, Stefania Petrini, Ranad Shaheen, Dov Tiosano, Rana Halloun, Ben Pode-Shakked, Hatice Mutlu Albayrak, Emreguel Isik, Jan M. Wit, Marcus Dittrich, Bruna L. Freire, Debora R. Bertola, Alexander A. L. Jorge, Ortal Barel, Ataf H. Sabir, Amal M. J. Al Tenaiji, Sulaima M. Taji, Nouriya Al-Sannaa, Hind Al-Abdulwahed, Maria Cristina Digilio, Melita Irving, Yair Anikster, Gandham S. L. Bhavani, Katta M. Girisha, Thomas Haaf, Jenny C. Taylor, Bruno Dallapiccola, Fowzan S. Alkuraya, Ruey-Bing Yang, Marco Tartaglia
Summary: Bi-allelic inactivating variants in SCUBE3 gene result in a previously unrecognized syndromic disorder characterized by growth retardation, skeletal abnormalities, distinctive craniofacial features, and dental anomalies. Functional studies demonstrate the involvement of SCUBE3 in modulating BMP signaling pathway to regulate growth, morphogenesis, bone, and teeth development. Knockout mice for SCUBE3 exhibit similar phenotypes, implicating the crucial role of SCUBE3 in these processes.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Biology
Ya-Lang Huang, Ming-Ting Huang, Pei-Shan Sung, Teh-Ying Chou, Ruey-Bing Yang, An-Suei Yang, Chung-Ming Yu, Yu-Wen Hsu, Wei-Chiao Chang, Shie-Liang Hsieh
Summary: Ya-Lang Huang et al. report a mechanism for TLR3-mediated signaling after immune simulation and influenza virus infection by way of the co-receptor CLEC18A. This study found that a single amino acid change in CLEC18A(S339R) can enhance the production of type I and type III interferons to suppress viral replication, and increase mice survival rate after flu infection infection.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ku-Chi Tsao, Yuh-Charn Lin, Yi-Ting Chen, Shih-Lei Lai, Ruey-Bing Yang
Summary: This study demonstrates the critical cooperation between SCUBE1 and SCUBE2 in regulating angiogenic cell behaviors and the formation of functional vessels during zebrafish embryonic development.
CARDIOVASCULAR RESEARCH
(2022)
Article
Engineering, Biomedical
Yu-Feng Hu, An-Sheng Lee, Shih-Lin Chang, Shien-Fong Lin, Ching-Hui Weng, Hsin-Yu Lo, Pei-Chun Chou, Yung-Nan Tsai, Yen-Ling Sung, Chien-Chang Chen, Ruey-Bing Yang, Yuh-Charn Lin, Terry B. J. Kuo, Cheng-Han Wu, Jin-Dian Liu, Tze-Wen Chung, Shih-Ann Chen
Summary: A silk fibroin hydrogel can directly convert rat quiescent ventricular cardiomyocytes into pacemaker cardiomyocytes by inducing the ectopic expression of the vascular endothelial cell-adhesion glycoprotein cadherin, exhibiting functional and morphological features of genuine sinoatrial-node cardiomyocytes both in vitro and in vivo. This approach could provide a scalable production of biological pacemakers for human use by utilizing biomaterials with suitable properties.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Pei-Chun Chou, Chih-Min Liu, Ching-Hui Weng, Kai-Chien Yang, Mei-Ling Cheng, Yuh-Charn Lin, Ruey-Bing Yang, Bai-Chuang Shyu, Song-Kun Shyue, Jin-Dian Liu, Shih-Pin Chen, Michael Hsiao, Yu-Feng Hu
Summary: This study reveals how fibroblasts drive the normal function of the sinoatrial node (SAN) by regulating metabolic reprogramming and rhythmic activity. The study also identifies the critical role of Aldoc in the interaction between fibroblasts and pacemaker cardiomyocytes.
CIRCULATION RESEARCH
(2022)
Article
Hematology
Hem Kumar Tamang, Ruey-Bing Yang, Zong-Han Song, Shao-Chun Hsu, Chien-Chung Peng, Yi-Chung Tung, Bing-Hsiean Tzeng, Chien-Chang Chen
Summary: This study explores the expression and role of Ca(v)3.2 in platelet function, revealing its importance for optimal platelet activation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Shuo-Ming Ou, Ming-Tsun Tsai, Huan-Yuan Chen, Fu-An Li, Kuo-Hua Lee, Wei-Cheng Tseng, Fu-Pang Chang, Yao-Ping Lin, Ruey-Bing Yang, Der-Cherng Tarng
Summary: Plasma galectin-3 is associated with organ fibrosis, and this study explored the potential of urinary galectin-3 as a biomarker for kidney disease progression. Patients with higher urinary galectin-3 levels had lower eGFRs and higher proteinuria levels. Higher levels of urinary galectin-3 were also associated with more severe renal fibrosis. The study suggests that urinary galectin-3 levels may be useful for identifying patients at high risk of kidney disease progression and renal fibrosis.
Article
Cell Biology
Yingzi Liu, Christian F. Guerrero-Juarez, Fei Xiao, Nitish Udupi Shettigar, Raul Ramos, Chen-Hsiang Kuan, Yuh-Charn Lin, Luis de Jesus Martinez Lomeli, Jung Min Park, Ji Won Oh, Ruiqi Liu, Sung-Jan Lin, Marco Tartaglia, Ruey-Bing Yang, Zhengquan Yu, Qing Nie, Ji Li, Maksim Plikus
Summary: Hair follicle stem cells are regulated by dermal papilla fibroblasts, which promote hair growth by secreting factors and influencing the mesenchymal niche through the Scube3/TGF-beta mechanism.
DEVELOPMENTAL CELL
(2022)
Article
Pharmacology & Pharmacy
Yue-Zhi Lee, Hsing-Yu Hsu, Cheng-Wei Yang, Yi-Ling Lin, Sui-Yuan Chang, Ruey-Bing Yang, Jian-Jong Liang, Tai-Ling Chao, Chun-Che Liao, Han-Chieh Kao, Jang-Yang Chang, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee
Summary: Ciclesonide blocks coronavirus-induced cytokine production by increasing I kappa B alpha protein levels and decreasing p65 nuclear translocation, and it can be used in the treatment of COVID-19 patients. The combination of Ciclesonide and dbq33b synergistically decreases cytokine levels and inhibits coronavirus replication. Therefore, this combination therapy is a promising treatment option for COVID-19 patients with high viral loads and NF-kappa B-mediated cytokine storms.
Article
Hematology
Binay K. Sahoo, Yuh-Charn Lin, Cheng-Fen Tu, Wei-Ju Liao, Ling -Hui Li, Kurt Yun Mou, Shu-Ping Wang, Chi-Tai Yeh, Chi-Yuan Yao, Hsin-An Hou, Wen -Chien Chou, Hwei-Fang Tien, Ruey-Bing Yang
Summary: A hallmark of MLL-r acute myeloid leukemia is addiction to protein tyrosine kinase signaling, particularly FLT3 signaling. This study reveals that SCUBE1 is a direct target of HOXA9/MEIS1 and is highly expressed on the MLL-r cell surface. SCUBE1 binds to both the FLT3 ligand and the extracellular ligand-binding domains of FLT3, facilitating activation of the FLT3-LYN signaling axis. Targeting surface SCUBE1 with an antibody-drug conjugate leads to decreased cell viability specifically in MLL-r leukemia. SCUBE1 is a potential therapeutic target for MLL rearrangement-induced leukemia.
Correction
Pharmacology & Pharmacy
Yue-Zhi Lee, Hsing-Yu Hsu, Cheng-Wei Yang, Yi-Ling Lin, Sui-Yuan Chang, Ruey-Bing Yang, Jian-Jong Liang, Tai-Ling Chao, Chun-Che Liao, Han-Chieh Kao, Jang-Yang Chang, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee
Review
Cell Biology
Yuh-Charn Lin, Binay K. Sahoo, Shiang-Shin Gau, Ruey-Bing Yang
Summary: The SCUBE family consists of three highly conserved proteins in vertebrates that play important roles in various physiological and pathological processes. Both soluble and membrane-associated SCUBEs are involved in signaling pathways and have been implicated in cancer, skeletal disease, and cardiovascular disease.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Oncology
Cheng-Fen Tu, Fu-An Li, Ling-Hui Li, Ruey-Bing Yang
Summary: Core fucosylation mediated by FUT8 enhances signaling of TGF-beta receptor, promoting breast cancer invasion and metastasis. Quantitative glycoproteomics identified 140 common core-fucosylated target glycoproteins, while pathway analysis highlighted crucial signaling networks like core fucosylation of integrin alpha v beta 5 or IL6ST for breast cancer cell invasion and migration.
BREAST CANCER RESEARCH
(2022)