A Golgi-localized Mannosidase (MAN1B1) Plays a Non-enzymatic Gatekeeper Role in Protein Biosynthetic Quality Control

Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP

(2013) Shujuan Pan et al.   MOLECULAR BIOLOGY OF THE CELL

UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum

(2013) Sean P. Ferris et al.   MOLECULAR BIOLOGY OF THE CELL

Diversity in the origins of proteostasis networks — a driver for protein function in evolution

(2013) Evan T. Powers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Specificity and Regulation of the Endoplasmic Reticulum-Associated Degradation Machinery

(2013) Jessica Merulla et al.   TRAFFIC

MAN1B1 Deficiency: An Unexpected CDG-II

(2013) Daisy Rymen et al.   PLoS Genetics

Cleaning Up: ER-Associated Degradation to the Rescue

(2012) Jeffrey L. Brodsky   CELL

A Shared Endoplasmic Reticulum-associated Degradation Pathway Involving the EDEM1 Protein for Glycosylated and Nonglycosylated Proteins

(2012) Marina Shenkman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis

(2012) Daniel N. Hebert et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mutations in the Alpha 1,2-Mannosidase Gene, MAN1B1, Cause Autosomal-Recessive Intellectual Disability

(2011) Muhammad Arshad Rafiq et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Characterization of Early EDEM1 Protein Maturation Events and Their Functional Implications

(2011) Taku Tamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Endoplasmic Reticulum-associated Degradation (ERAD) Pathway in Degradation of Hepatitis C Virus Envelope Proteins and Production of Virus Particles

(2011) Mohsan Saeed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system

(2011) Shujuan Pan et al.   MOLECULAR BIOLOGY OF THE CELL

Bypass of glycan-dependent glycoprotein delivery to ERAD by up-regulated EDEM1

(2011) Efrat Ron et al.   MOLECULAR BIOLOGY OF THE CELL

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Protein N-glycosylation, protein folding, and protein quality control

(2011) Jürgen Roth et al.   MOLECULES AND CELLS

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

(2011) M. H. Smith et al.   SCIENCE

Protein Sorting Receptors in the Early Secretory Pathway

(2010) Julia Dancourt et al.   Annual Review of Biochemistry

EDEM1 accelerates the trimming of  1,2-linked mannose on the C branch of N-glycans

(2010) N. Hosokawa et al.   GLYCOBIOLOGY

Mannose Trimming Is Required for Delivery of a Glycoprotein from EDEM1 to XTP3-B and to Late Endoplasmic Reticulum-associated Degradation Steps

(2010) Bella Groisman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Oligosaccharide Recognition of Misfolded Glycoproteins by OS-9 in ER-Associated Degradation

(2010) Tadashi Satoh et al.   MOLECULAR CELL

Physiology and pathology of proteostasis in the early secretory compartment

(2010) Tiziana Anelli et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of the Lectin VIP36 in Post-ER Quality Control of Human α1-Antitrypsin

(2010) Veronika Reiterer et al.   TRAFFIC

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency

(2009) Shujuan Pan et al.   HEPATOLOGY

EDEM1 Recognition and Delivery of Misfolded Proteins to the SEL1L-Containing ERAD Complex

(2009) James H. Cormier et al.   MOLECULAR CELL

ERAD substrates: Which way out?

(2009) Daniel N. Hebert et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Dual Task for the Xbp1-responsive OS-9 Variants in the Mammalian Endoplasmic Reticulum

(2008) Riccardo Bernasconi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of ERGIC-53 as an intracellular transport receptor of α1-antitrypsin

(2008) Beat Nyfeler et al.   JOURNAL OF CELL BIOLOGY

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Endoplasmic Reticulum (ER) Mannosidase I Is Compartmentalized and Required for N-Glycan Trimming to Man5–6GlcNAc2 in Glycoprotein ER-associated Degradation

(2007) Edward Avezov et al.   MOLECULAR BIOLOGY OF THE CELL