Xenobiotic Pregnane X Receptor (PXR) Regulates Innate Immunity via Activation of NLRP3 Inflammasome in Vascular Endothelial Cells

Inflammasomes are Differentially Expressed in Cardiovascular and other Tissues

(2017) Y. Yin et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Endothelial NLRP3 Inflammasome Activation and Enhanced Neointima Formation in Mice by Adipokine Visfatin

(2014) Min Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

New paradigms in inflammatory signaling in vascular endothelial cells

(2013) Lei Xiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility

(2013) Han Xiao et al.   CIRCULATION

Inflammasomes and host defenses against bacterial infections

(2013) Gregory I Vladimer et al.   CURRENT OPINION IN MICROBIOLOGY

An evolving new paradigm: endothelial cells – conditional innate immune cells

(2013) Jietang Mai et al.   Journal of Hematology & Oncology

Shear stress activation of nuclear receptor PXR in endothelial detoxification

(2013) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 Inflammasome Blockade Inhibits VEGF-A-Induced Age-Related Macular Degeneration

(2013) Alexander G. Marneros   Cell Reports

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages

(2012) Yu Qiao et al.   FEBS LETTERS

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

(2012) Sarah L Doyle et al.   NATURE MEDICINE

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

(2012) Jie Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress

(2011) Karen E. Swales et al.   CARDIOVASCULAR RESEARCH

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes

(2009) Niresh Hariparsad et al.   NUCLEIC ACIDS RESEARCH

Initial description of the human NLRP3 promoter

(2008) J P Anderson et al.   GENES AND IMMUNITY