Article
Pharmacology & Pharmacy
Sahebgowda Sidramagowda Patil, Ramani Soundararajan, Jutaro Fukumoto, Mason Breitzig, Helena Hernandez-Cuervo, Matthew Alleyn, Muling Lin, Venkata Ramireddy Narala, Richard Lockey, Narasaiah Kolliputi, Lakshmi Galam
Summary: High concentrations of supplementary oxygen are used to treat acute lung injury and acute respiratory distress syndrome, but prolonged exposure can lead to mitochondrial damage and protein misfolding in the endoplasmic reticulum. Akap1 plays a critical role in maintaining mitochondrial homeostasis, and its deficiency exacerbates lung injury. Deleting Akap1 increases ER stress in response to hyperoxia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tae Woo Kim
Summary: Angelica gigas has a potent anti-tumor and anti-cancer effect. This study focused on the bioactive compound nodakenin and its effects on breast cancer. Nodakenin was found to inhibit breast cancer cell viability, decrease tumor volume in mice, and induce apoptosis. It also affected signaling pathways and calcium release. Additionally, nodakenin combined with radiation overcame radioresistance in breast cancer cells. These findings suggest nodakenin as a potential therapeutic strategy for breast cancer.
Article
Endocrinology & Metabolism
Nirav Florian Chhabra, Anna-Lena Amend, Aimee Bastidas-Ponce, Sibylle Sabrautzki, Marta Tarquis-Medina, Stephan Sachs, Marina Rubey, Bettina Lorenz-Depiereux, Annette Feuchtinger, Mostafa Bakhti, Heiko Lickert, Gerhard K. H. Przemeck, Martin Hrabe de Angelis
Summary: This study investigated the consequences of a point mutation in the Pdia6 gene on β-cell development and function in mice. The mutation led to hypoinsulinemia and hyperglycemia in adult mice, attributed to loss of β-cell function and identity. It was observed that mutant mice displayed reduced insulin-expressing β-cells and altered expression of key markers.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Jeong Woo Kim, Jinwon Choi, Moon Nyeo Park, Bonglee Kim
Summary: Pancreatic cancer is the seventh leading cause of cancer-related mortality. Gallic acid, as a potential anticancer agent, has shown inhibitory effects on cell proliferation and induction of apoptosis in pancreatic cancer cells. It activates the p38 pathway and endoplasmic reticulum stress pathway through the generation of reactive oxygen species, suggesting its therapeutic potential for pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Dong-Oh Moon
Summary: This review provides a comprehensive analysis of the multifaceted role of calcium in apoptosis regulation, focusing on its associated signaling pathways and molecular mechanisms. It explores the impact of calcium on apoptosis through its effects on various cellular compartments and highlights its connection to ER stress. Additionally, it discusses the interplay between calcium and proteins such as calpains, calmodulin, and Bcl-2 family members, and its role in regulating caspase activation and pro-apoptotic factor release. Understanding the complex relationship between calcium and apoptosis is crucial for identifying potential treatment options for diseases associated with imbalanced cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yixuan Zhang, Jianzhuang Wu, Yao Fu, Ranran Yu, Haochen Su, Qisi Zheng, Hao Wu, Siqi Zhou, Kun Wang, Jing Zhao, Shanshan Shen, Guifang Xu, Lei Wang, Chao Yan, Xiaoping Zou, Ying Lv, Shu Zhang
Summary: This study identified Hesperadin as a potent anti-cancer compound against pancreatic cancer (PC) by inhibiting cell growth and inducing apoptotic cell death. Mechanistic studies revealed that Hesperadin increased GADD45A expression via ATF4, leading to apoptosis. Immunohistochemical staining demonstrated the correlation between ATF4 and GADD45A expression. PC xenograft studies confirmed the inhibitory effect of Hesperadin on PC cell growth in vivo.
Article
Oncology
Hao Wang, Yingxing Xu, Jialin Sun, Zhongguo Sui
Summary: In this study, the novel curcumin derivative 1g was found to inhibit tumor growth in colon cancer cells by inducing apoptosis through mechanisms such as changes in mitochondrial membrane potential, enhanced pro-apoptotic activity, and ROS production. These findings suggest that targeted strategies based on ROS could be a promising approach to inhibit colon cancer proliferation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Food Science & Technology
Xianling Dai, Qin Kuang, Yan Sun, Minxuan Xu, Liancai Zhu, Chenxu Ge, Jun Tan, Bochu Wang
Summary: The study revealed that Fisetin can efficiently attenuate NAFLD by restraining ROS generation and alleviating mitochondrial impairment.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Medicine, Research & Experimental
Shamit Kumar, Tusar Kanta Acharya, Ramizur Rahaman Halder, Parnasree Mahapatra, Young-Tae Chang, Chandan Goswami
Summary: Menthol is a bioactive compound that causes various physiological changes, and its cellular and subcellular effects are still poorly understood. In this study, the effects of menthol on mitochondrial metabolism were characterized. Menthol regulates mitochondrial Ca2+, ATP, superoxides, cardiolipin, membrane potential, and ER-mito contact sites. Additionally, menthol acts as a cooling agent for mitochondria and protects against mitochondrial damage from certain toxins. These findings suggest that menthol could be used as a supplementary agent for anti-aging, anti-cancer, and anti-inflammatory purposes where higher mitochondrial temperature is prevalent.
Article
Biochemistry & Molecular Biology
Sarah Hartwick Bjorkman, Renata Oliveira Pereira
Summary: Mitochondria-derived reactive oxygen species (mtROS) can disrupt cellular redox homeostasis, but moderate mitochondrial stress may enhance the organism's ability to cope with stress. By regulating different signaling pathways, mtROS play a key role in maintaining cardiometabolic health.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Tanaporn Phetruen, Bloem van Dam, Sittinan Chanarat
Summary: This study investigates the effects of andrographolide in Saccharomyces cerevisiae and finds that it induces cytotoxicity and affects various cellular processes. Moreover, andrographolide also leads to the precipitation of biomolecules secreted from yeast cells, adding an additional source of stress. This study provides insights into the cellular effects and potential mechanisms of andrographolide.
Article
Multidisciplinary Sciences
Tulin Dadali, Anne R. Diers, Shiva Kazerounian, Senthil K. Muthuswamy, Pallavi Awate, Ryan Ng, Saie Mogre, Carrie Spencer, Katerina Krumova, Hannah E. Rockwell, Justice McDaniel, Emily Y. Chen, Fei Gao, Karl T. Diedrich, Vijetha Vemulapalli, Leonardo O. Rodrigues, Viatcheslav R. Akmaev, Khampaseuth Thapa, Manuel Hidalgo, Arindam Bose, Vivek K. Vishnudas, A. James Moser, Elder Granger, Michael A. Kiebish, Stephane Gesta, Niven R. Narain, Rangaprasad Sarangarajan
Summary: Reactive oxygen species (ROS) play a role in triggering cell signaling events to promote and maintain tumorigenicity. Chemotherapy and radiation can induce ROS to elicit cell death, making it possible to target ROS pathways for effective anti-cancer therapeutics. Coenzyme Q(10) is shown to increase ROS generation when delivered to increase mitochondrial Q-pool, resulting in anti-cancer effects in a pancreatic cancer model.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Qun Zhao, Yun Bi, Jian Guo, Yingxiang Liu, Jing Zhong, Yongqiang Liu, Longrui Pan, Yang Guo, Yan Tan, Xianjun Yu
Summary: Pristimerin induces apoptosis in CRC cells by regulating proapoptotic protein Noxa and triggering ROS-mediated ER stress signaling activation. Pristimerin significantly elevates ER stress-related proteins expression, leading to activation of the IRE1 alpha/JNK signal pathway. Pristimerin exhibits apoptosis-inducing activities in both HCT116 colon cancer xenografts and APC(min/+) mice.
Article
Immunology
Hong-Lei Wang, Fen-Qiao Chen, Li-Juan Wu
Summary: The study found that ephedrine has therapeutic effects on the development of chronic obstructive pulmonary disease (COPD). It can alleviate cell death, oxidative stress, and inflammatory response by reducing reactive oxygen species (ROS) levels. Additionally, ephedrine can suppress endoplasmic reticulum (ER) stress signaling and mitigate cigarette smoke-induced damage to cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mini Jeong, Jong-Il Shin, Jaewook Cho, Yong-Joon Jeon, Jin-Hyun Kim, Jeehee Youn, Kyungho Lee
Summary: In this study, the pro-apoptotic effects of docosahexaenoic acid (DHA) in human fibroblast-like synovial cells from rheumatoid arthritis (RA) patients were investigated. The results showed that DHA treatment induced caspase-8-dependent apoptosis in a dose-dependent manner and reduced the TNF-alpha-mediated induction of MMP-9 and IL-1 beta. DHA also induced ER stress and upregulated the expression of death receptor 5 (DR5) through the activation of CHOP. These findings suggest that DHA can induce apoptosis in RA-FLSs through the upregulation of DR5 via the activation of CHOP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)