Nuclear Factor-κB-inducing Kinase (NIK) Contains an Amino-terminal Inhibitor of Apoptosis (IAP)-binding Motif (IBM) That Potentiates NIK Degradation by Cellular IAP1 (c-IAP1)

The TRAF3 adaptor protein drives proliferation of anaplastic large cell lymphoma cells by regulating multiple signaling pathways

(2014) Israel Muro et al.   CELL CYCLE

Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting

(2013) T.-C. Yeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site

(2012) Gladys de Leon-Boenig et al.   STRUCTURE

NF-κB in immunobiology

(2011) Matthew S Hayden et al.   CELL RESEARCH

Non-canonical NF-κB signaling activation and regulation: principles and perspectives

(2011) Bahram Razani et al.   IMMUNOLOGICAL REVIEWS

CARD-Mediated Autoinhibition of cIAP1's E3 Ligase Activity Suppresses Cell Proliferation and Migration

(2011) Juanita Lopez et al.   MOLECULAR CELL

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Classical and/or alternative NF- B pathway activation in multiple myeloma

(2010) Y. N. Demchenko et al.   BLOOD

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

TRAF3 Controls Activation of the Canonical and Alternative NFκB by the Lymphotoxin Beta Receptor

(2010) Pradeep Bista et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic Activation of NF- B

(2010) L. M. Staudt   Cold Spring Harbor Perspectives in Biology

Two distinct signalling cascades target the NF-κB regulatory factor c-IAP1 for degradation

(2009) Rebecca A. Csomos et al.   BIOCHEMICAL JOURNAL

Enhanced Cytoprotective Effects of the Inhibitor of Apoptosis Protein Cellular IAP1 through Stabilization with TRAF2

(2009) Rebecca A. Csomos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their Processing

(2009) Young Eun Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP21

(2008) John W. Blankenship et al.   BIOCHEMICAL JOURNAL

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

IAPs: What's in a Name?

(2008) Srinivasa M. Srinivasula et al.   MOLECULAR CELL

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY