Inhibition of Protein Phosphatase 2A (PP2A) Prevents Mcl-1 Protein Dephosphorylation at the Thr-163/Ser-159 Phosphodegron, Dramatically Reducing Expression in Mcl-1-amplified Lymphoma Cells
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inhibition of Protein Phosphatase 2A (PP2A) Prevents Mcl-1 Protein Dephosphorylation at the Thr-163/Ser-159 Phosphodegron, Dramatically Reducing Expression in Mcl-1-amplified Lymphoma Cells
Authors
Keywords
-
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 32, Pages 21950-21959
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2014-06-18
DOI
10.1074/jbc.m114.587873
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity
- (2014) R. W. Rooswinkel et al. BLOOD
- Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53
- (2014) G. L. Kelly et al. GENES & DEVELOPMENT
- Concordance of Genomic Alterations between Primary and Recurrent Breast Cancer
- (2014) F. Meric-Bernstam et al. MOLECULAR CANCER THERAPEUTICS
- Many players in BCL-2 family affairs
- (2014) Tudor Moldoveanu et al. TRENDS IN BIOCHEMICAL SCIENCES
- The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis
- (2013) Hui Ren et al. CANCER LETTERS
- Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer
- (2013) Parthasarathy Seshacharyulu et al. CANCER LETTERS
- Programming cancer cells for high expression levels of Mcl1
- (2013) Franziska Ertel et al. EMBO REPORTS
- Concurrent MCL1 and JUN amplification in pseudomyxoma peritonei: a comprehensive genetic profiling and survival analysis
- (2013) Terence T Sio et al. JOURNAL OF HUMAN GENETICS
- The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak
- (2013) Xiaobo Cao et al. Molecular Cancer
- Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis
- (2013) T. Okamoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition
- (2012) Chander Peddaboina et al. BMC CANCER
- Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency
- (2012) Guo Wei et al. CANCER CELL
- Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons
- (2012) M M Magiera et al. CELL DEATH AND DIFFERENTIATION
- A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival
- (2012) Nicole A. Cohen et al. CHEMISTRY & BIOLOGY
- Targeting the Bcl-2 family for cancer therapy
- (2012) Shibu Thomas et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation
- (2012) Kenichiro Doi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Thr 163 Phosphorylation Causes Mcl-1 Stabilization when Degradation Is Independent of the Adjacent GSK3-Targeted Phosphodegron, Promoting Drug Resistance in Cancer
- (2012) Shanna K. Nifoussi et al. PLoS One
- Targeting Mcl-1 for the therapy of cancer
- (2011) Bridget A Quinn et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Low expression of PP2A regulatory subunit B55α is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients
- (2011) P P Ruvolo et al. LEUKEMIA
- SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
- (2011) Hiroyuki Inuzuka et al. NATURE
- Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
- (2011) Ingrid E. Wertz et al. NATURE
- MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner
- (2010) Marc Germain et al. EMBO JOURNAL
- Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
- (2010) Margaret E Harley et al. EMBO JOURNAL
- Ubiquitin-Independent Degradation of Antiapoptotic MCL-1
- (2010) D. P. Stewart et al. MOLECULAR AND CELLULAR BIOLOGY
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Phenylarsine Oxide Binding Reveals Redox-Active and Potential Regulatory Vicinal Thiols on the Catalytic Subunit of Protein Phosphatase 2A
- (2010) Timothy D. Foley et al. NEUROCHEMICAL RESEARCH
- Mcl-1 Integrates the Opposing Actions of Signaling Pathways That Mediate Survival and Apoptosis
- (2009) C. Morel et al. MOLECULAR AND CELLULAR BIOLOGY
- Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
- (2009) Martin Schwickart et al. NATURE
- Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding
- (2008) X. Deng et al. BLOOD
- A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins
- (2008) Hugh K. Arnold et al. CANCER AND METASTASIS REVIEWS
- PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)
- (2008) Veerle Janssens et al. TRENDS IN BIOCHEMICAL SCIENCES
- Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
- (2007) Melissa R. Junttila et al. FASEB JOURNAL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started