A Colon Cancer-derived Mutant of Krüppel-like Factor 5 (KLF5) Is Resistant to Degradation by Glycogen Synthase Kinase 3β (GSK3β) and the E3 Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (FBW7α)

Investigation of the atypicalFBXW7mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

(2013) Hayley Davis et al.   GUT

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis

(2011) Dong Zhao et al.   CARCINOGENESIS

Wnt signaling and colon tumorigenesis — A view from the periphery

(2011) Antony W. Burgess et al.   EXPERIMENTAL CELL RESEARCH

Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer

(2011) Jing Zhang et al.   GASTROENTEROLOGY

The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation

(2010) Dong Zhao et al.   CANCER RESEARCH

The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs

(2010) Ning Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations

(2010) Mandayam O Nandan et al.   Molecular Cancer

Mammalian Krüppel-Like Factors in Health and Diseases

(2010) Beth B. McConnell et al.   PHYSIOLOGICAL REVIEWS

Haploinsufficiency of Kruppel-Like Factor 5 Rescues the Tumor-Initiating Effect of the ApcMin Mutation in the Intestine

(2009) B. B. McConnell et al.   CANCER RESEARCH

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

(2009) Jin-Tang Dong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer

(2009) Anna Isinger Ekstrand et al.   Familial Cancer

Acetylation of KLF5 Alters the Assembly of p15 Transcription Factors in Transforming Growth Factor-β-mediated Induction in Epithelial Cells

(2009) Peng Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Resolution Melting Analysis for Rapid Detection ofKRAS, BRAF,andPIK3CAGene Mutations in Colorectal Cancer

(2008) Lisa Simi et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Pro-proliferative Factor KLF5 Becomes Anti-proliferative in Epithelial Homeostasis upon Signaling-mediated Modification

(2008) Peng Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-like Factor 5 Controls Keratinocyte Migration via the Integrin-linked Kinase

(2008) Yizeng Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation Regulates Nuclear Localization of Krüppel-like Factor 5

(2008) James X. Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY