Article
Cell Biology
Lin Zhu, Shulei He, Lu Huang, Dongni Ren, Tiejian Nie, Kai Tao, Li Xia, Fangfang Lu, Zixu Mao, Qian Yang
Summary: Accumulation of oxidative stress is closely associated with aging and aging-related diseases. Understanding the molecular mechanisms that regulate oxidative stress is crucial for uncovering the pathogenesis of these diseases. Chaperone-mediated autophagy (CMA), a selective lysosome-dependent degradation process, has been shown to maintain cellular homeostasis and attenuate oxidative stress. This study reveals that CMA directly degrades Keap1, leading to increased Nrf2 levels, nuclear translocation, and expression of antioxidative genes. Furthermore, a feed-forward loop between CMA and Nrf2 is identified. These findings highlight the role of CMA as a regulator of the Keap1-Nrf2 pathway and emphasize its antioxidative function.
Article
Biochemistry & Molecular Biology
Nabila Jahan, Apu Chowdhury, Ting Li, Ke Xu, Fen Wei, Sicen Wang
Summary: The study demonstrates that neferine (NF) may potentially regulate Benign Prostate hyperplasia (BPH) by balancing between oxidative stress (OS) and apoptosis through the activation of the Nrf2-ARE pathway. NF significantly reduced cell proliferation and regulated apoptosis in BPH-1 cells at 48 hours, showing remarkable antioxidant and anti-apoptotic effects.
Article
Pharmacology & Pharmacy
Amir Jalali, Sara Mahmoudi, Amir Larki Harchegani, Javad Mohammadiasl, Ahmad Ahmadzadeh
Summary: The study evaluated the expression of Nrf2, Bcl2, and Bcl-XL genes in acute myeloid leukemia patients, finding increased levels in new AML patients, particularly those undergoing chemotherapy. This high expression may be associated with poor treatment response, chemoresistance, and disease recurrence. Inhibition of Nrf2 could potentially enhance the efficacy of anticancer therapy in leukemia.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Pankaj K. Singh, Anil K. Jaiswal, Vivek K. Pawar, Kavit Raval, Animesh Kumar, Himangsu K. Bora, Anuradha Dube, Manish K. Chourasia
PHARMACEUTICAL RESEARCH
(2018)
Article
Immunology
Anil Kumar Jaiswal, Mohanraj Sadasivam, Nathan K. Archer, Robert J. Miller, Carly A. Dillen, Advaitaa Ravipati, Pyong Woo Park, Shukti Chakravarti, Lloyd S. Miller, Abdel Rahim A. Hamad
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Anil Kumar Jaiswal, Sangeet Makhija, Natalie Stahr, Maninder Sandey, Amol Suryawanshi, Ankit Saxena, Pradeep K. Dagur, J. Philip McCoy, Stewart J. Levine, Amarjit Mishra
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Anil Kumar Jaiswal, Sangeet Makhija, Natalie Stahr, Maninder Sandey, Amol Suryawanshi, Amarjit Mishra
Article
Endocrinology & Metabolism
Anil Kumar Jaiswal, Mohanraj Sadasivam, Susan Aja, Abdel Rahim A. Hamad
WORLD JOURNAL OF DIABETES
(2020)
Article
Immunology
Ferrin Antony, Chetan Pundkar, Maninder Sandey, Anil K. Jaiswal, Amarjit Mishra, Ashok Kumar, Rudragouda Channappanavar, Amol Suryawanshi
Summary: HSV-1 infection of the cornea leads to herpetic stromal keratitis, causing severe inflammation and vision impairment. Exogenous rIFN-lambda treatment shows potential therapeutic efficacy in controlling inflammation and vision impairment induced by HSV-1 infection.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Physiology
Anil Kumar Jaiswal, Jyoti Yadav, Sangeet Makhija, Maninder Sandey, Amol Suryawanshi, Amit Kumar Mitra, Amarjit Mishra
Summary: The study found that aged mice exhibit increased airway hyperresponsiveness, mixed granulomatous airway inflammation, and changes in immune response, suggesting that the development of airway inflammation may be age-related. Additionally, the age-dependent decline in SPLUNC1 levels may be involved in developing steroid-resistant airway inflammation and asthma heterogeneity.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Immunology
Anil Kumar Jaiswal, Jyoti Yadav, Sangeet Makhija, Suman Mazumder, Amit Kumar Mitra, Amol Suryawanshi, Maninder Sandey, Amarjit Mishra
Summary: The study revealed a direct regulatory role of the Irg1/itaconate pathway in dendritic cells for the development of airway inflammation, suggesting a possible therapeutic target in modulating allergic asthma.
MUCOSAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jonathan Marable, Damien Ruiz, Anil K. Jaiswal, Ritankar Bhattacharya, Robert Pantazes, Payal Agarwal, Amol S. Suryawanshi, Deepa Bedi, Amarjit Mishra, Bruce F. Smith, Maninder Sandey
Summary: The study developed chimeric heavy chain antibodies against CTLA4 for canine cancer treatment, using nanobodies and recombinant antibodies to specifically bind to canine CTLA4, offering a novel therapeutic approach.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Oncology
Karim Iskander, Marilene Paquet, Cory Brayton, Anil K. Jaiswal
Article
Respiratory System
Anil Kumar Jaiswal, Amarjit Mishra
Summary: This study found that ADAMTS7 plays a pivotal role in house dust mite-induced airway inflammation and Th2 immune response. By regulating dendritic cell function, it reduces allergic sensitization and Th2 immune response.
Article
Oncology
Nilesh Mani, Sushil K. Aggarwal, Ishan Kumar, Abhijit Mandal, Garima Jaiswal, Rakesh Ranjan, Anil K. Jaiswal, Neha Gupta, Ankita Singh, Ankur Mourya, Lalit M. Aggarwal, Sunil Choudhary
Summary: A comparison was made between simultaneous integrated boost (SIB) and sequential boost (SEQ) in the treatment of locally advanced head and neck cancer (HNC). The study found comparable overall survival (OS) and disease-free survival (DFS) outcomes between the two treatment arms, but SIB was associated with higher acute toxicities compared to SEQ.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Immunology
Anil K. Jaiswal, Maninder Sandey, Amol Suryawanshi, Russell C. Cattley, Amarjit Mishra
IMMUNITY INFLAMMATION AND DISEASE
(2019)
Meeting Abstract
Immunology
Anil Kumar Jaiswal, Maninder Sandey, Amol Suryawanshi, Russell C. Cattley, Amarjit Mishra
JOURNAL OF IMMUNOLOGY
(2019)
Retraction
Oncology
Delwin J. Long, Amos Gaikwad, Asha Multani, Sen Pathak, Charles A. Montgomery, Frank J. Gonzalez, Anil K. Jaiswal
