Characterization of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Trafficking Reveals a Novel Lysosomal Targeting Mechanism via Amyloid Precursor-like Protein 2 (APLP2)
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Title
Characterization of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Trafficking Reveals a Novel Lysosomal Targeting Mechanism via Amyloid Precursor-like Protein 2 (APLP2)
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 288, Issue 15, Pages 10805-10818
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2013-02-20
DOI
10.1074/jbc.m113.453373
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- Disrupted recycling of the low density lipoprotein receptor by PCSK9 is not mediated by residues of the cytoplasmic domain
- (2010) Thea Bismo Strøm et al. MOLECULAR GENETICS AND METABOLISM
- LDLR Expression and Localization Are Altered in Mouse and Human Cell Culture Models of Alzheimer's Disease
- (2010) Jose F. Abisambra et al. PLoS One
- The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
- (2009) S. A. Bustin et al. CLINICAL CHEMISTRY
- Mechanism for Amyloid Precursor-like Protein 2 Enhancement of Major Histocompatibility Complex Class I Molecule Degradation
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- (2009) Paul Saftig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
- (2009) J. C. Y. Chan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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