WD Repeat Protein WDR48 in Complex with Deubiquitinase USP12 Suppresses Akt-dependent Cell Survival Signaling by Stabilizing PH Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1)

SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells

(2013) Ganglong Gao et al.   MOLECULAR BIOLOGY REPORTS

The Ubiquitin-specific Protease 12 (USP12) Is a Negative Regulator of Notch Signaling Acting on Notch Receptor Trafficking toward Degradation

(2012) Julien Moretti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells

(2012) Zhang Zhiqiang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer

(2012) X Li et al.   ONCOGENE

Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance

(2011) F. Andreozzi et al.   DIABETOLOGIA

Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt

(2011) Xin Li et al.   EMBO REPORTS

p53 regulation by ubiquitin

(2011) Christopher L. Brooks et al.   FEBS LETTERS

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Human ELG1 Regulates the Level of Ubiquitinated Proliferating Cell Nuclear Antigen (PCNA) through Its Interactions with PCNA and USP1

(2010) Kyoo-young Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Histone H2A and H2B Deubiquitination andXenopusDevelopment by USP12 and USP46

(2010) Heui-Yun Joo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

 -TrCP-Mediated Ubiquitination and Degradation of PHLPP1 Are Negatively Regulated by Akt

(2009) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

SCOP/PHLPP and its functional role in the brain

(2009) Kimiko Shimizu et al.   Molecular BioSystems

UAF1 Is a Subunit of Multiple Deubiquitinating Enzyme Complexes

(2008) Martin A. Cohn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis

(2008) J Liu et al.   ONCOGENE

PHLiPPing the switch on Akt and protein kinase C signaling

(2008) John Brognard et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM