Tumor-derived Mutations in the Gene Associated with Retinoid Interferon-induced Mortality (GRIM-19) Disrupt Its Anti-signal Transducer and Activator of Transcription 3 (STAT3) Activity and Promote Oncogenesis

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis

(2012) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

Expression and clinical significance of GRIM-19 in lung cancer

(2012) Xiao-Yun Fan et al.   MEDICAL ONCOLOGY

Downregulation of GRIM-19 is associated with hyperactivation of p-STAT3 in hepatocellular carcinoma

(2012) Feifei Li et al.   MEDICAL ONCOLOGY

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

(2012) Bradley N Bidwell et al.   NATURE MEDICINE

STAT3 negatively regulates thyroid tumorigenesis

(2012) J. P. Couto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of GRIM-19 promotes growth and migration of human glioma cells

(2011) Yanmin Zhang et al.   CANCER SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Depletion of GRIM-19 accelerates hepatocellular carcinoma invasion via inducing EMT and loss of contact inhibition

(2011) Hongbo Hao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

GRIM-19 Disrupts E6/E6AP Complex to Rescue p53 and Induce Apoptosis in Cervical Cancers

(2011) Ying Zhou et al.   PLoS One

Identification of a Structural Motif in the Tumor-Suppressive Protein GRIM-19 Required for Its Antitumor Activity

(2010) Shreeram C. Nallar et al.   AMERICAN JOURNAL OF PATHOLOGY

Hyper-IgE Syndrome with STAT3 Mutation: A Case Report in Mainland China

(2010) Lixin Xie et al.   Clinical & Developmental Immunology

Stat3 Orchestrates Tumor Development and Progression: The Achilles Heel of Head and Neck Cancers?

(2010) M. Masuda et al.   CURRENT CANCER DRUG TARGETS

Diffuse Large B Cell Lymphoma in Hyper-IgE Syndrome Due To STAT3 Mutation

(2010) Attila Kumánovics et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Overexpression of GRIM-19 in Cancer Cells Suppresses STAT3-Mediated Signal Transduction and Cancer Growth

(2010) Takashi Okamoto et al.   MOLECULAR CANCER THERAPEUTICS

A novel mutation in the signal transducer and activator of transcription 3 (STAT3) gene, in hyper-IgE syndrome

(2010) Anastasios D. Papanastasiou et al.   MOLECULAR IMMUNOLOGY

Down-Regulation of GRIM-19 Expression Is Associated With Hyperactivation of STAT3-Induced Gene Expression and Tumor Growth in Human Cervical Cancers

(2009) Ying Zhou et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3–CTTN–Akt pathway in esophageal squamous cell carcinoma

(2009) X-L Du et al.   ONCOGENE

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Effects of Plasmid-Based Stat3-Specific Short Hairpin RNA and GRIM-19 on PC-3M Tumor Cell Growth

(2008) L. Zhang et al.   CLINICAL CANCER RESEARCH

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS