Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Medicine, Research & Experimental
M. Vijaykrishnaraj, Kuiwu Wang
Summary: Natural products found in various natural foods have potential biological activities, including plants, fruits, vegetables, and marine life. The biochemical reaction known as advanced glycation end products (AGEs) in the human body contributes to the pathogenesis of diabetic complications. Researchers are exploring the use of food-derived natural products to control AGEs-related disease complications.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xiao Yang, Cong-Jin Liu, Zhen-Zhen Wang, Dong Ding, Jing-Wen Shi, Xin-Tong Wu, Lian-Wen Sun, Yu-Bo Fan
Summary: AGEs negatively impact the mechanosensitivity of osteocytes, affecting the bone remodeling process. This study provides a new perspective on exploring the mechanism of osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Patricia Budihartanti Liman, Karina Shasri Anastasya, Nabila Maudy Salma, Yenny Yenny, Meutia Atika Faradilla
Summary: The aim of this study was to analyze scientific articles on advanced glycation end products (AGEs) and obesity using bibliometric methods. The results showed an increase in studies on processed foods and obesity, with the United States making the largest contribution in this field. Open access journals had higher citation numbers and younger publication years compared to closed access journals.
Article
Chemistry, Multidisciplinary
Jingxia Han, Yu Sun, Ting Wu, Xiaohui Hou, Shaoting Zheng, Haohao Zhang, Tingting Lin, Huijuan Liu, Tao Sun
Summary: In this study, echinacoside-zinc coordination polymers (ECH-Zn) were synthesized and further wrapped in hyaluronic acid/poly(ethylenimine) (HA-PEI) nanoparticles to obtain HA-PEI-coated ECH-Zn (PPZn) nanoparticles. The PPZn nanoparticles showed better antiglycation effects in the skin and enhanced the uptake and utilization of ECH-Zn. Mechanistic studies revealed that MDM2 can interact with STAT2 to promote RAGE transcriptional activation, while PPZn can inhibit the expression and interaction of the MDM2/STAT2 complex, leading to the suppression of RAGE transcriptional activation and exerting antiglycation effects.
Article
Nutrition & Dietetics
Elom K. Aglago, Ana-Lucia Mayen, Viktoria Knaze, Heinz Freisling, Veronika Fedirko, David J. Hughes, Li Jiao, Anne Kirstine Eriksen, Anne Tjonneland, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Anna Birukov, Domenico Palli, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Fulvio Ricceri, Bas Bueno-de-Mesquita, Jeroen W. G. Derksen, Guri Skeie, Inger Torhild Gram, Torkjel Sandanger, J. Ramon Quiros, Leila Lujan-Barroso, Maria-Jose Sanchez, Pilar Amiano, Maria-Dolores Chirlaque, Aurelio Barricarte Gurrea, Ingegerd Johansson, Jonas Manjer, Aurora Perez-Cornago, Elisabete Weiderpass, Marc J. Gunter, Alicia K. Heath, Casper G. Schalkwijk, Mazda Jenab
Summary: The study found a negative association between dietary advanced glycation end-products (dAGEs) and colorectal cancer risk, contrary to initial hypotheses. More research is needed to confirm these results and better understand the exact role of these substances in the development of colorectal cancer.
Article
Allergy
Kimberley Cousins, Kaori Sano, Brandon Lam, Katharina Roltgen, Disha Bhavsar, Gagandeep Singh, Oliver Mcrae, Stephanie Jeong, Nouran Aboelregal, Hsi-en Ho, Scott Boyd, Florian Krammer, Charlotte Cunningham-Rundles
Summary: This study quantitatively examined SARS-CoV-2 antibodies in current Ig products and found significantly increased antibody values in products manufactured after 2020. Enzyme-linked immunosorbent assays were used to assess IgG-binding activities against recombinant SARS-CoV-2 proteins and the ability to inhibit SARS-CoV-2 variants from binding to receptors.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Agriculture, Dairy & Animal Science
Pornsucha Palaseweenun, Esther A. Hagen-Plantinga, J. Thomas Schonewille, Gerrit Koop, Claire Butre, Melliana Jonathan, Peter A. Wierenga, Wouter H. Hendriks
Summary: The study revealed a correlation between dietary AGEs and the urinary excretion of AGEs in pet dogs and cats, indicating endogenous formation of these compounds under physiological conditions in both species.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Daniela Briceno Noriega, Hannah E. Zenker, Cresci-Anne Croes, Arifa Ewaz, Janneke Ruinemans-Koerts, Huub F. J. Savelkoul, R. J. Joost van Neerven, Malgorzata Teodorowicz
Summary: Recent evidence has shown that the Maillard reaction affects the structure and function of food proteins. The modified proteins resulting from the Maillard reaction can interact with immune cells and affect their biological properties, including digestibility, bioavailability, immunogenicity, and allergenicity. Receptors on immune cells recognize these modified proteins, leading to enhanced cytokine production and immune responses. This review discusses the immunogenicity of advanced glycation end products (AGEs) in food, their interactions with immune cell receptors, and their clinical relevance in food allergies.
Article
Biochemistry & Molecular Biology
Utkarsh Reddy Addi, Sneha Jakhotia, S. Sreenivasa Reddy, G. Bhanuprakash Reddy
Summary: Aging is a major risk factor for diseases, including neurodegenerative disorders. This study found that the accumulation of AGEs in the brain increases with age, which may lead to neuronal damage by affecting ER homeostasis, UPS, autophagic flux, and neuronal growth factors.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Gastroenterology & Hepatology
Armando Rojas, Cristian Lindner, Ivan Schneider, Ileana Gonzalez, Miguel Angel Morales
Summary: Compelling evidence from clinical and experimental research shows that activation of the receptor for advanced glycation end products (RAGE) axis is crucial in the development of neoplasms, including gastric cancer (GC). RAGE plays a significant role in establishing an inflammatory environment that supports tumor growth and dissemination, and acts as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori infection. This review highlights the contribution of RAGE axis overexpression and activation to the proliferation, survival, and invasive phenotypes of GC cells, as well as the potential role of RAGE gene polymorphisms in susceptibility and prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Nutrition & Dietetics
Jinluan Chen, Djawad Radjabzadeh, Carolina Medina-Gomez, Trudy Voortman, Joyce B. J. van Meurs, M. Arfan Ikram, Andre G. Uitterlinden, Robert Kraaij, M. Carola Zillikens
Summary: This study investigated the association between dietary advanced glycation end products (AGEs) and gut microbiota, as well as the relationship between skin AGEs and gut microbiota. The results showed that dietary AGEs were not associated with the diversity or dissimilarity of gut microbiota, but were associated with the abundance of certain bacterial genera. Skin AGEs were associated with gut microbiota composition and metabolic pathways. These findings suggest a potential interaction between gut microbiota and AGE metabolism.
Review
Immunology
Maria J. Monroy-Iglesias, Silvia Crescioli, Kerri Beckmann, Nga Le, Sophia N. Karagiannis, Mieke Van Hemelrijck, Aida Santaolalla
Summary: The humoral immune response is closely associated with the development of cancer, and antibodies have been found to have predictive value in assessing site-specific cancer risk. Different types of antibodies, especially immunoglobulin isotypes, tumor-associated antigen-specific, and self-reactive antibodies, are linked to cancer risk.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Ting Li, Lihong Niu, Xianghong Li, Faxiang Wang, Yiqun Huang, Yongle Liu
Summary: Lipid oxidation, protein degradation, and AGEs formation increased during freezing-thawing cycles and heat treatment. Freezing-thawing treatment accelerated the heat-induced increase of AGEs in surimi products. Correlation analysis showed that lipid oxidation and protein degradation promoted the chemical synthesis of AGEs, while Schiff base oxidation likely occurred only under thermal treatment.
Article
Endocrinology & Metabolism
Tian Jiang, Yi Zhang, Fang Dai, Chao Liu, Honglin Hu, Qiu Zhang
Summary: This study aimed to explore the role of non-invasive detection of advanced glycation end products (AGEs) in the early screening of diabetes mellitus (DM) in the Chinese community and investigate the moderating effect of body mass index (BMI) and metabolic indexes. The results indicate that in Chinese participants with high AGE accumulation, priority should be given to the quality of metabolic-related indicators such as BMI, TG, and TC to effectively reduce fasting blood glucose levels.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Biochemistry & Molecular Biology
Takujiro Homma, Yuji Takeda, Tomoyuki Nakano, Shinya Akatsuka, Daisuke Kinoshita, Toshihiro Kurahashi, Shinichi Saitoh, Ken-ichi Yamada, Satoshi Miyata, Hironobu Asao, Kaoru Goto, Tetsu Watanabe, Masafumi Watanabe, Shinya Toyokuni, Junichi Fujii
Summary: The study revealed that in double knockout mice lacking Sod1 and Akr1a, cessation of AsA supplementation resulted in oxidative damage in lung tissues, triggering immune responses and ultimately leading to death. These findings suggest that the pivotal role of AsA in combating ROS is primarily seen in pulmonary tissues exposed to a hyperoxygenic microenvironment.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yasumasa Okazaki, Yuuri Ishidzu, Fumiya Ito, Hiromasa Tanaka, Masaru Hori, Shinya Toyokuni
Summary: The study utilized electron paramagnetic resonance spectroscopy to quantify different reactive oxygen species generated by NTP in the presence of antioxidants, demonstrating significant scavenging effects of antioxidants on reactive oxygen species. The importance of redox cycling of Asc/DHA and metabolites of DHA, as well as the impact of ROS-reducing compounds like EGCG, were highlighted in the study for NTP application in cells and tissues. Further research is needed to explore the interaction between ROS and biomolecules to enhance the medical applications of NTP.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Shinya Toyokuni
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Shinya Toyokuni, Yingyi Kong, Danyang Mi
Summary: This commentary discusses a highly cited paper by Robert L Heath and Lester Packer, published in the Archives of Biochemistry and Biophysics in 1968. The paper reveals that isolated chloroplasts undergo cyclic peroxidation of tri-unsaturated fatty acids when exposed to visible light, contributing to the concept of electron transfer reactions.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Pathology
Lin Yue, Yaguang Luo, Li Jiang, Yoshitaka Sekido, Shinya Toyokuni
Summary: Poly (rC)-binding proteins 1 and 2 (PCBP1/2) play an important role in mesothelial cells and malignant mesothelioma (MM) by conferring resistance to ferroptosis. Knockdown of PCBP2 decreases the expression of transferrin receptor 1 (TfR1) and ferritin heavy chain (FTH), inhibits cell proliferation, and increases sensitivity to ferroptosis in MM cells.
PATHOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Kazuhiro Nishiyama, Akiyuki Nishimura, Kakeru Shimoda, Tomohiro Tanaka, Yuri Kato, Takahiro Shibata, Hiroshi Tanaka, Hitoshi Kurose, Yasu-Taka Azuma, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Philip Eaton, Koji Uchida, Motohiro Nishida
Summary: This study identified a mechanism called redox-dependent alternative internalization (REDAI) that promotes the internalization and degradation of the purinergic P2Y(6) receptor (P2Y(6)R). The researchers found that both synthetic and natural compounds containing electrophilic isothiocyanate groups can modify P2Y(6)R and facilitate its internalization and degradation. This mechanism, mediated by cysteine modification, may also play a role in the internalization of other G protein-coupled receptors (GPCRs) and potentially limit the progression of colitis.
Article
Biochemistry & Molecular Biology
Hao Zheng, Li Jiang, Tsuyoshi Tsuduki, Marcus Conrad, Shinya Toyokuni
Summary: The study demonstrates the use of HNEJ-1 antibody to detect ferroptosis in various tissues and developmental stages, showing age-dependent increase and iron accumulation in ferroptosis. Additionally, ferroptosis was found to impact aging mice and embryonic erythropoiesis.
Article
Biochemistry & Molecular Biology
Fumiya Ito, Katsuhiro Kato, Izumi Yanatori, Toyoaki Murohara, Shinya Toyokuni
Summary: The study proposed a novel mechanism in which extracellular vesicles mediate the transfer of mutagenic factors associated with asbestos to mesothelial cells. It was found that FedEVs transport iron from ferroptotic macrophages to mesothelial cells, contributing to asbestos-induced mesothelioma. Mesothelial cells receiving higher amounts of FedEVs were found to be in mitotic phases, particularly in S and G2/M phases.
Article
Biology
Satomi Yogosawa, Makiko Ohkido, Takuro Horii, Yasumasa Okazaki, Jun Nakayama, Saishu Yoshida, Shinya Toyokuni, Izuho Hatada, Mitsuru Morimoto, Kiyotsugu Yoshida
Summary: The study reveals that Dyrk2 deficiency results in multiple organ congenital malformations in mice, with main characteristics of respiratory failure and insufficient airway and alveolar development, leading to sudden death of mutant pups soon after birth. Through ex vivo lung culture, Foxf1 expression and its target genes in Dyrk2-deficient lung are rescued by restoring Shh signaling activity, providing insights into the function of Dyrk2.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Masanori Itakura, Kosuke Yamaguchi, Roma Kitazawa, Sei-Young Lim, Yusuke Anan, Jun Yoshitake, Takahiro Shibata, Lumi Negishi, Hikari Sugawa, Ryoji Nagai, Koji Uchida
Summary: Reducing sugars can react with proteins to form advanced glycation end products (AGEs), which are pathogenic molecules involved in inflammation and human diseases. This study identifies histone as a cell-surface receptor for AGEs and suggests that AGEs may also play a role in homeostatic response by binding to histone.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Hirotoshi Soyama, Miki Nishio, Junji Otani, Toshiko Sakuma, Shintaro Takao, Shigeo Hara, Takaaki Masuda, Koshi Mimori, Shinya Toyokuni, John P. Lydon, Kazuwa Nakao, Hiroshi Nishina, Takumi Fukumoto, Tomohiko Maehama, Akira Suzuki
Summary: Breast cancer is the most common malignancy in women, and basal-like breast cancer (BLBC) is the most aggressive subtype. The Hippo-transcriptional coactivator with PDZ-binding motif (TAZ) pathway is found to be a key driver in the onset and progression of BLBC. Utilizing mouse models and human breast cancer cell lines, researchers have justified targeting the Hippo-TAZ pathway as a potential therapy for BLBC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Analytical
Jun Yoshitake, Mayuko Azami, Haruka Sei, Daisuke Onoshima, Kumiko Takahashi, Akiyoshi Hirayama, Koji Uchida, Yoshinobu Baba, Takahiro Shibata
Summary: Extracellular vesicles are nanoscale lipid bilayer vesicles released by almost all cell types. They play an important role in cell-cell communication and have potential applications in disease diagnosis and drug delivery. In this study, a size-exclusion chromatography column device was developed for rapid and effective isolation of extracellular vesicles.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fumie Nakashima, Juan A. Gimenez-Bastida, Paula B. Luis, Sai H. Presley, Robert E. Boer, Manuel Chiusa, Takahiro Shibata, Gary A. Sulikowski, Ambra Pozzi, Claus Schneider
Summary: Consecutive oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2 produces hemiketal ei-cosanoids, HKE2 and HKD2, which promote angiogenesis by inducing endothelial cell tubulogenesis. This study identifies VEGFR2 as a mediator of HKE2-induced angiogenesis in vitro and in vivo. HKE2 treatment increases the phosphorylation of VEGFR2 and downstream kinases ERK and Akt, while HKE2-mediated effects are blocked by the VEGFR2 inhibitor vatalanib. These findings suggest a potential therapeutic strategy utilizing drugs targeting the arachidonic acid pathway for antiangiogenic therapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Meeting Abstract
Oncology
Shinya Akatsuka, Li Jiang, Asmaa Elzawahry, Mamoru Kato, Yukari Totsuka, Tatsuhiro Shibata, Shinya Toyokuni
Article
Oncology
Kyoko Yamashita, Kenichi Kohashi, Yuichi Yamada, Shinya Akatsuka, Kunihiro Ikuta, Yoshihiro Nishida, Shinya Toyokuni, Yoshinao Oda
Summary: This study investigated the progression process and factors related to poor prognosis in DDLPS, finding that MDM2 and HMGA2 genes were associated with poor and good prognosis, respectively. The amplification or gain ratio of MDM2/HMGA2 was determined to have significant prognostic value in patients with DDLPS.
GENES CHROMOSOMES & CANCER
(2021)