Article
Cell Biology
Xinyu Liu, Pin Huan, Baozhong Liu
Summary: This study reveals the crucial role of nonmuscle myosin II (NM II) in the morphogenesis of the larval shell field in L. goshimai. Inhibition of NM II phosphorylation results in the complete loss of the larval shell plate and altered morphology and cell specification in the shell field.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Debdatta Halder, Ditipriya Mallick, Ananya Chatterjee, Siddhartha S. Jana
Summary: Cell migration is a crucial process in cancer metastasis, immune-cell navigation, stem cell homing, and development, influenced by the diverse migratory mechanisms utilized by cells due to the heterogeneity of tissue environments. The activity and complexity of actomyosin networks play a significant role in cell motility mechanisms. Understanding the regulation and function of nonmuscle myosin IIs is important for designing therapeutic strategies to inhibit cancer metastasis.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biophysics
Takumi Saito, Wenjing Huang, Tsubasa S. Matsui, Masahiro Kuragano, Masayuki Takahashi, Shinji Deguchi
Summary: This study investigates the characteristics of nonmuscle myosin II (NMII) in actin stress fibers in nonmuscle cells and proposes factors that determine the number of NMII. Experimental results confirm that the number of NMII lies between the functions of bearing cellular tension under static conditions and promptly disintegrating upon forced cell shortening, allowing cells to adaptively respond to mechanical stress.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Review
Multidisciplinary Sciences
Andrei I. Ivanov, Susana Lechuga, Armando Marino-Melendez, Nayden G. Naydenov
Summary: The integrity and functions of epithelial barriers depend on the formation of adherens junctions and tight junctions, which are associated with the cortical cytoskeleton composed of actin filaments and nonmuscle myosin II motors. Different actin and myosin isoforms play distinct roles in the assembly, stability, and remodeling of junctions. This review focuses on the roles of actin and myosin in controlling the integrity and barrier properties of various epithelia.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Chemistry, Physical
Wantong Zhao, Xuebai Lan, Baojun Wang, Maohong Fan, Riguang Zhang
Summary: In this study, the inverse Mo6C4/Cu catalyst is modeled and predicted to promote C2 oxygenates formation in syngas transformation. The results show that the inverse Mo6C4/Cu catalyst greatly improves catalytic performance and facilitates C2 oxygenate production compared to previous catalysts. This is attributed to the synergistic effect between Mo6C4 cluster with Cu catalyst, which easily activates CO to produce CH2 monomer and facilitates CO insertion into CH2 to CH2CO.
APPLIED SURFACE SCIENCE
(2023)
Article
Cell Biology
Fereshteh R. Najafabadi, Mark Leaver, Stephan W. Grill
Summary: Contractile forces in the actomyosin cortex are essential for cellular morphogenesis. The formation of nonmuscle myosin II (NMII) filaments in the cortex is not well understood. This study demonstrates that two proteins in the RhoA GTPase pathway, LET-502 and MEL-11, play a role in regulating NMII filament assembly dynamics. The coordination of these regulators generates a gradient of free NMII in the cytoplasm, driving NMII motors towards the cytokinetic ring and facilitating the up-regulation of cortical contractility during cytokinesis.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Chemistry, Medicinal
Sarmistha Mitra, Yeasmin Akter Munni, Raju Dash, Armin Sultana, Il Soo Moon
Summary: This study explores the mechanism of action of Withania somnifera (WS) on neuritogenesis and finds that it promotes neuronal growth. Additionally, WS was observed to modulate the neurotrophin signaling pathway and steroidal lactones in WS might act as nerve growth factor (NGF)-mimetics. These findings suggest the potential of WS as a therapeutic agent for memory-related neurological disorders.
PHYTOTHERAPY RESEARCH
(2022)
Article
Multidisciplinary Sciences
So-Jin Park-Holohan, Elisabetta Brunello, Thomas Kampourakis, Martin Rees, Malcolm Irving, Luca Fusi
Summary: The regulation of myosin activity in heart muscle involves the modulation of myosin motors available for interaction with thin filaments. Stretch or increased RLC phosphorylation do not have a direct effect on the activation of folded myosin motors at physiological conditions, but can lead to delayed activation and increased force production at higher calcium concentrations. This suggests a calcium-dependent interfilament signaling pathway involving thin filament sensitization and thick filament mechanosensing in the increased contractility induced by RLC phosphorylation and stretch in the heart.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Organic
Xin Zhao, Fang Yang, Lin-Lin Wang, Jing Guo, Yu-Qin Xu, Zi-Sheng Chen, Kegong Ji
Summary: The paper introduces a copper-catalyzed approach for site-selective amination of p-aminophenol derivatives with arylamines, without the need for prefunctionalization of the reactants. This novel method efficiently produces single site selective aminated products with moderate to good yields using air as a terminal oxidant.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Neurosciences
Irene Pertici, Giulio Bianchi, Lorenzo Bongini, Dan Cojoc, Manuel H. Taft, Dietmar J. Manstein, Vincenzo Lombardi, Pasquale Bianco
Summary: This study introduced a nanomachine made from frog muscle myosin, capable of mimicking the force and velocity effects seen in muscle, and found its performance to be dependent on Ca2+ concentration. The Ca2+-sensitivity was identified as a class-specific property of muscle myosin, as the performance was Ca2+-independent when using myosin from mammalian skeletal muscle, which was further supported by simulation models.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Cell Biology
James M. Cowan, Jacob J. Duggan, Breanne R. Hewitt, Ryan J. Petrie
Summary: This review discusses the distinct modes of 3D cell migration and the role of non-muscle myosin II (NMII) in generating mechanical forces for migration. It also highlights the potential roles of tropomyosins and septins in regulating NMII activity during 3D cell migration. Investigating the mechanisms controlling NMII activity is important for understanding how cells transition between different modes of 3D migration in response to the physical environment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Physical
Rongbo Sun, Cong Wei, Zixiang Huang, Shuwen Niu, Xiao Han, Cai Chen, Haoran Wang, Jia Song, Jun-Dong Yi, Geng Wu, Dewei Rao, Xusheng Zheng, Yuen Wu, Gongming Wang, Xun Hong
Summary: Manipulating the oxidation state of Cu catalysts can enhance the selectivity and activity of CO2RR. By using a defect construction strategy, crystalline/amorphous Cu2+1O/CuOx heterostructures with abundant Cu-0 and Cu delta+ (0 < delta < 1) sites were prepared, showing high Faradaic efficiency for C2+ products. Real-time monitoring and DFT calculations further confirmed the stability and efficacy of the heterostructured Cu catalyst.
Article
Nanoscience & Nanotechnology
Li-Xia Liu, Yanming Cai, Huitong Du, Xuanzhao Lu, Xiang Li, Fuqiang Liu, Jiaju Fu, Jun-Jie Zhu
Summary: Porous Cu catalysts with a cavity structure were developed for the efficient conversion of CO2 to C2+ fuels. The catalysts exhibited high C2+ Faradaic efficiency and partial current density at a low applied potential in a microfluidic flow cell. In situ Raman tests and finite element simulation indicated that the cavity structure promoted the C-C coupling process by enriching the local concentration of CO intermediates.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Inorganic & Nuclear
Christian O. Blanco, Ligia Llovera, Alberto Herrera, Romano Dorta, Giuseppe Agrifoglio, Domenico Venuti, Vanessa R. Landaeta, Jesus Pastran
Summary: The synthesis of ruthenium (II) piano-stool complexes with bis-(+)-camphopyrazole ligands and their catalytic performance in the transfer hydrogenation of benzaldehyde and valeraldehyde were evaluated. The complexes showed moderate yields and selectivity when using isopropanol and formic acid as hydrogen donors, with C-2 symmetry ligands outperforming C-1 symmetry ligands in all evaluated systems.
INORGANICA CHIMICA ACTA
(2021)
Article
Virology
Jian Chen, Jian Liu, Zhilu Chen, Daobin Feng, Cuisong Zhu, Jun Fan, Shuye Zhang, Xiaoyan Zhang, Jianqing Xu
Summary: This study reveals the crucial role of nonmuscle myosin IIA (MYH9) in regulating influenza A virus (IAV) infection and replication. MYH9 can interact with the viral nucleoprotein (NP) and interrupt the formation of viral ribonucleoprotein (vRNP) complexes, leading to a suppression of viral RNA transcription and replication. These findings shed new light on the complicated interactions between IAV and its host, making MYH9 a potential target for antiviral drug development.
Article
Cell Biology
Debdatta Halder, Shekhar Saha, Raman K. Singh, Indranil Ghosh, Ditipriya Mallick, Sumit K. Dey, Arijit Ghosh, Benu Brata Das, Somiranjan Ghosh, Siddhartha S. Jana
MOLECULAR BIOLOGY OF THE CELL
(2019)
Article
Pharmacology & Pharmacy
Amrita Saha, Anindita Bhattacharjee, Amit Vij, Pijush K. Das, Arijit Bhattacharya, Arunima Biswas
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Pankaj Kumar, Shashi Kiran, Shekhar Saha, Zhangli Su, Teressa Paulsen, Ajay Chatrath, Yoshiyuki Shibata, Etsuko Shibata, Anindya Dutta
Article
Hematology
Kallesh D. Jayappa, Vicki L. Gordon, Christopher G. Morris, Briana Wilson, B. Dharmaveer Shetty, Konrad J. Cios, Puja C. Arora, Krista M. Isaac, Shekhar Saha, Timothy P. Bender, Michael E. Williams, Craig A. Portell, Michael J. Weber
Summary: The Bcl-2 inhibitor venetoclax has shown great clinical responses in CLL, but resistance to treatment can occur due to overexpression of multiple antiapoptotic proteins such as Mcl-1, Bcl-xL, and Bcl-2. Research indicates the persistence of antiapoptotic multidrug-resistant CLL cells in patients, requiring simultaneous inhibition of multiple antiapoptotic proteins for effective treatment.
Article
Oncology
Shashi Kiran, Briana Wilson, Shekhar Saha, Julia Ann Graff, Anindya Dutta
Summary: This study revealed that the E6-USP46 complex in cervical cancer increases Cdt2 levels and decreases Set8 levels, promoting cancer progression, and suggests USP46 as a potential drug target for HPV-induced cancers.
Article
Biochemistry & Molecular Biology
Jeet Banerjee, Anindita Bhattacharjee, Arunima Biswas, Shital K. Chattopadhyay
Summary: This study investigates the photophysical properties and anti-leishmanial activity of eight indolo[3,2-a]phenanthridine derivatives. The compounds show interesting photophysical properties and exhibit potential as anti-leishmanial agents, possibly through minor groove binding.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Rituparna Bhaduri, Saikat Mandal, Swarup Kumar Tarai, Angana Pan, Subhajit Mukherjee, Arka Bagchi, Arunima Biswas, Sankar Ch. Moi
Summary: A series of Pt(II) complexes with nitrogen, sulfur, and oxygen donors were synthesized and evaluated for their anticancer activity. The theoretical calculations supported the experimental findings, and various techniques were used to analyze the binding modes and binding aptitude of the complexes. The results showed that these complexes exhibited in vitro anticancer activity against breast cancer cells and induced cell death through ROS generation.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Cell Biology
Myron K. Gibert, Aditya Sarkar, Bilhan Chagari, Christian Roig-Laboy, Shekhar Saha, Sylwia Bednarek, Benjamin Kefas, Farina Hanif, Kadie Hudson, Collin Dube, Ying Zhang, Roger Abounader
Summary: Transcribed ultraconserved regions (TUCRs) are putative lncRNA molecules transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. Despite the poor conservation of lncRNAs, the study of TUCRs in diseases, including cancer, remains understudied. This review summarizes the current literature on TUCRs in cancer, including their deregulated expression, functional roles, mechanisms of action, and clinical perspectives.
Editorial Material
Immunology
Arijit Bhattacharya, Christopher Fernandez-Prada, Guillermo Daniel Alonso, Arunima Biswas
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pritha Mukherjee, Arka Bagchi, Ananya Banerjee, Himansu Roy, Arijit Bhattacharya, Arunima Biswas, Urmi Chatterji
Summary: Ineffective cancer treatment is closely related to the persistence of cancer stem cells (CSCs). The study found that the expression of phosphatidylinositol-3-kinase (PI3K) was upregulated in breast CSCs, while phosphodiesterase 4 (PDE4) levels were higher in breast CSCs compared to normal stem cells. The PDE4 inhibitor rolipram was able to induce cell cycle arrest and apoptosis in CSCs by modulating the PI3K signaling pathway.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Chemistry, Physical
Rituparna Bhaduri, Angana Pan, Swarup Kumar Tarai, Saikat Mandal, Arka Bagchi, Arunima Biswas, Sankar Ch. Moi
Summary: This study investigates the biological importance of a series of Pd(II) based complexes as potential anticancer drug candidates and their interactions with biomolecules. The results demonstrate that these complexes exhibit high binding affinity with DNA and BSA, leading to the generation of reactive oxygen species (ROS) in tumor cells, resulting in cell death and apoptosis.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Swarup Kumar Tarai, Saikat Mandal, Arup Tarai, Ipsita Som, Angana Pan, Arka Bagchi, Arunima Biswas, Sankar Ch. Moi
Summary: The bidentate donor Schiff base HL was synthesized for the synthesis of CuL2 complex, which showed important structural features characterized by single crystal X-ray diffraction and spectroscopic methods. DFT/TD-DFT studies were performed to evaluate the structure optimization, electronic spectroscopy data, and binding interactions with biomolecules. The Cu(II) complex showed anticancer activity and less toxicity compared to cisplatin and oxaliplatin, and the mechanism of cell death was assessed via apoptosis or necrosis.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Swarup Kumar Tarai, Arup Tarai, Saikat Mandal, Bhaskar Nath, Ipsita Som, Rituparna Bhaduri, Arka Bagchi, Solanki Sarkar, Arunima Biswas, Sankar Ch. Moi
Summary: The bidentate ligand thiosemicarbazone (H3L) and its Ni(II) complex were synthesized and characterized. The complexes have square planar geometry and show binding abilities with DNA and BSA. The DFT/TD-DFT simulations and theoretical analysis provided insights into the reactivity, bonding mode, and bio-molecular affinity of the compounds. The compounds also demonstrated antiproliferative activity and cell death mechanisms against HEK293 and MCF-7 cell lines.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Suman Mandal, Mitali Sarkar, Shanku Denrah, Arka Bagchi, Arunima Biswas, David B. Cordes, Alexandra M. Z. Slawin, Nitis Chandra Saha
Summary: A new pyrazole Schiff-base ligand and its two Ni(II) complexes have been synthesized and characterized. The complexes show promising catalytic and anticancer activities.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Angana Pan, Rituparna Bhaduri, Saikat Mandal, Swarup Kumar Tarai, Arka Bagchi, Arunima Biswas, Sankar Ch. Moi
Summary: Carrier ligand 2-(Piperidine-1-yl)ethylamine (PIEAM) was used to synthesize Pt(II) complexes as anticancer drug candidates. The complexes were characterized and their substitution reactions were studied. The binding activity with DNA and BSA, as well as the antineoplastic activity, were evaluated. The structural optimization, PASS prediction, and in silico ADME analysis further supported the experimental findings.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)