Rheb GTPase Regulates β-Secretase Levels and Amyloid β Generation

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

(2012) Fredrik Jeppsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer’s Disease and Beyond

(2012) Bastian Dislich et al.   Frontiers in Physiology

Rheb1 Is Required for mTORC1 and Myelination in Postnatal Brain Development

(2011) Jia Zou et al.   DEVELOPMENTAL CELL

Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

(2011) Nicole A. Neuman et al.   EMBO Molecular Medicine

Identification and biology of β-secretase

(2011) Patty C. Kandalepas et al.   JOURNAL OF NEUROCHEMISTRY

DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling

(2011) M. Miyashita et al.   MOLECULAR AND CELLULAR BIOLOGY

Rheb Is Essential for Murine Development

(2011) S. M. I. Goorden et al.   MOLECULAR AND CELLULAR BIOLOGY

AAV Transduction of Dopamine Neurons With Constitutively Active Rheb Protects From Neurodegeneration and Mediates Axon Regrowth

(2011) Sang Ryong Kim et al.   MOLECULAR THERAPY

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease

(2011) Robert Vassar et al.   Alzheimers Research & Therapy

SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function

(2010) Bing Gong et al.   AGING CELL

Downregulation of Notch Pathway by a  -Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model

(2010) C. L. Efferson et al.   CANCER RESEARCH

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing

(2010) Hirokazu Okada et al.   FASEB JOURNAL

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

(2010) Eugene L. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Nascent Peptide-dependent Translation Arrest Leads to Not4p-mediated Protein Degradation by the Proteasome

(2009) Lyudmila N. Dimitrova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling

(2009) A B Hanker et al.   ONCOGENE

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Amino acid regulation of TOR complex 1

(2008) Joseph Avruch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Alzheimer Disease Aβ Production in the Absence ofS-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts

(2008) Kulandaivelu S. Vetrivel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON