“Snapshots” of Ispinesib-induced Conformational Changes in the Mitotic Kinesin Eg5

The structure of the ternary Eg5–ADP–ispinesib complex

(2012) S. K. Talapatra et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

(2012) Adeline Goulet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural kinetics of myosin by transient time-resolved FRET

(2011) Yuri E. Nesmelov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Conserved L5 Loop Establishes the Pre-Powerstroke Conformation of the Kinesin-5 Motor, Eg5

(2010) Adam G. Larson et al.   BIOPHYSICAL JOURNAL

A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors

(2010) Howard A. Burris et al.   INVESTIGATIONAL NEW DRUGS

Loop L5 Acts as a Conformational Latch in the Mitotic Kinesin Eg5

(2010) William M. Behnke-Parks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinesins at a glance

(2010) S. A. Endow et al.   JOURNAL OF CELL SCIENCE

An allosteric transition trapped in an intermediate state of a new kinesin–inhibitor complex

(2009) Hung Yi Kristal Kaan et al.   BIOCHEMICAL JOURNAL

Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl- l -cysteine in tumor derived cell lines

(2009) Sergey Tcherniuk et al.   BIOCHEMICAL PHARMACOLOGY

ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism

(2009) Courtney L. Parke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Inhibition of Human KSP byIspinesib

(2008) Latesh Lad et al.   BIOCHEMISTRY

Southwest Oncology Group Phase II Study of Ispinesib in Androgen-Independent Prostate Cancer Previously Treated with Taxanes

(2008) Tomasz M. Beer et al.   Clinical Genitourinary Cancer