Editorial Material
Urology & Nephrology
Angelena Edwards, Niccolo M. Passoni, Rebecca Collins, Smitha Vidi, Jyothsna Gattineni, Linda A. Baker
Summary: This case study describes a term infant with 46, XY Denys-Drash syndrome who underwent peritoneal dialysis and surgical treatment for renal abnormalities without the use of chemotherapy.
Article
Oncology
Chisato Yokota, Naoki Kagawa, Koji Takano, Yasuyoshi Chiba, Manabu Kinoshita, Noriyuki Kijima, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama, Akihiro Tsuboi, Shuichi Izumoto, Haruhiko Kishima, Naoya Hashimoto
Summary: This study found that WT1 and HLA class I antigen expression in tumor cells significantly decreased after WT1 peptide vaccine treatment, and maintenance of WT1 expression during vaccination was associated with longer survival. High HLA class I antigen expression and low CD4(+)/CD8(+) TIL ratio in pre-vaccination samples were also linked to better outcomes. The number of infiltrating CD4(+) T cells decreased post-vaccination, providing insights into immune reactions during cancer immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Medical Laboratory Technology
Faliang Wang, Jiabin Cai, Jinhu Wang, Min He, Junqing Mao, Kun Zhu, Manli Zhao, Zhonghai Guan, Linjie Li, Hongchuan Jin, Qiang Shu
Summary: The study identified a case of Denys-Drash syndrome with an uncommon missense mutation in the WT1 gene, which may serve as a crucial marker in DDS. The mutated variant showed a weaker effect in inhibiting tumor cells compared to the wild-type WT1.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Brigitte Royer-Pokora, Maike Anna Busch, Sarah Tenbusch, Mathias Schmidt, Manfred Beier, Andrew D. Woods, Holger Thiele, Jaume Mora
Summary: Wilms tumors are childhood kidney tumors that are heterogeneous with distinct subgroups, including a subtype associated with WT1 gene mutations. Researchers have successfully established 11 cell lines from the WT1 mutant subtype, providing a valuable tool for studying the biology and genetics of this specific type of Wilms tumor. These cell lines may lead to new approaches in treatment development.
Review
Endocrinology & Metabolism
Jenny E. Blau, William F. Simonds
Summary: The regulation of serum calcium levels in humans involves the endocrine action of the parathyroid glands, vitamin D, and various target cells and tissues. Primary hyperparathyroidism is a disorder of mineral metabolism typically associated with elevated serum calcium and can be caused by uncontrolled release of parathyroid hormone from abnormal glands, sometimes linked to genetic mutations. Further research into familial HPT lacking known predisposition genes holds promise for the discovery of novel genes related to parathyroid tumor development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Manlio Tolomeo, Antonio Cascio
Summary: STAT3 is a complex regulator of transcription, with constitutive activation reported in many tumors but less frequent somatic mutations in cancer. Oncogenic targets of STAT3 have been identified, and inhibitors have been developed for cancer prevention and treatment. However, data suggest that STAT3 functions are multifaceted and its cellular role is determined by various signals and factors, making targeted therapies tailored to specific tumor types important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hong Liu, Chen Jin, Xia Yang, Nan Xia, Chunzhi Guo, Qian Dong
Summary: This study identified key genes of Wilms' tumor (WT) through bioinformatics analysis and validated the effects of AQP1 on cell invasion and migration in WT. Functional analysis highlighted the importance of cellular homeostasis and ion transport, revealing the regulatory network of key genes within cells.
Article
Physiology
Kyle Dickinson, Leah Hammond, Murielle Akpa, Lee Lee Chu, Caleb Tse Lalonde, Alexandre Goumba, Paul Goodyer
Summary: Mammalian nephrons originate from nephron progenitor cells expressing WT1, which is crucial for their development. WT1 primes the cells for nephrogenesis by inducing the expression of DNA repair gene Neil3, which protects the genome during kidney development. This study reveals the importance of lineage-specific DNA repair mechanisms in kidney development.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhenzhen Guo, Luyao Sun, Haojie Xia, Shibin Tian, Mengyue Liu, Jiejie Hou, Jiahuan Li, Haihong Lin, Gangjun Du
Summary: This study aimed to observe the differentiation effect of shikonin on Wilms' tumor 1 (WT1)-positive HL-60 cells and investigate the fate of the differentiated leukemia cells. The results showed that shikonin could decrease the WT1 protein level, promote leukemia cell differentiation, and inhibit cell proliferation while inducing apoptosis. The study also provided preliminary evidence for the protein-protein interactions between WT1 and CD34, suggesting their potential involvement in cell immaturity.
Review
Biotechnology & Applied Microbiology
Taylor P. Berke, Simon H. Slight, Salman M. Hyder
Summary: The tumor suppressor protein p53 plays a crucial role in preventing cancer. Mutations in the p53 gene are associated with various cancers. Reactivating mutant p53 protein and controlling the progression of triple-negative breast cancer (TNBC) through the use of non-toxic natural compounds is recommended.
ONCOTARGETS AND THERAPY
(2022)
Article
Oncology
Carolyn M. Jablonowski, Hyea Jin Gil, Emilia M. Pinto, Prahalathan Pichavaram, Andrew M. Fleming, Michael R. Clay, Dongli Hu, Christopher L. Morton, Shondra M. Pruett-Miller, Baranda S. Hansen, Xiang Chen, Karissa M. Dieseldorff Jones, Yanling Liu, Xiaotu Ma, Jun Yang, Andrew M. Davidoff, Gerard P. Zambetti, Andrew J. Murphy
Summary: The study identified potential mechanisms of TERT activation in Wilms tumor, including mutations in the TERT promoter, increased methylation of the promoter, and genomic copy number amplifications. Conversely, inactivating WT1 mutations were associated with low TERT RNA levels and telomerase activity. N-MYC overexpression led to increased TERT promoter activity and transcription.
Article
Zoology
Danny Schnerwitzki, Christoph Englert, Manuela Schmidt
Summary: The evolution of the four-segmented limb in therians is accompanied by changes in development and sensorimotor control. By deleting the Wt1 gene in a specific group of interneurons in the spinal cord of mice, we found that this perturbation affects the coordination of limb movements, particularly in the forelimbs. Interestingly, these effects are similar to locomotor deficits observed when sensory feedback is impaired.
Article
Pathology
Xiaoli Xu, Rui Bi, Ruohong Shui, Baohua Yu, Yufan Cheng, Xiaoyu Tu, Wentao Yang
Summary: In invasive breast carcinoma with >90% mucinous component, WT1 expression is significantly associated with low-intermediate nuclear/histological grade, ER positivity, HER2 negativity, a lower Ki-67 proliferation index and no LN metastasis. Micropapillary architecture was observed in 80% of cases.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nicole Wagner, Marina Ninkov, Ana Vukolic, Gunseli Cubukcuoglu Deniz, Minoo Rassoulzadegan, Jean-Francois Michiels, Kay-Dietrich Wagner
Summary: The Wilms' tumor suppressor Wt1 is involved in multiple developmental processes and adult tissue homeostasis. The dynamic expression pattern of Wt1 during cardiomyocyte differentiation and its overexpression in ES cells reduces their phenotypical cardiomyocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Seyed Mostafa Monzavi, Amir Ali Hamidieh, Mohammad Vasei, Jafar Ai, Naser Ahmadbeigi, Hamid Arshadi, Samad Muhammadnejad, Abdol-Mohammad Kajbafzadeh
Summary: This study aimed to investigate the feasibility of isolating WT1-reactive T cells from PBMCs and assess their cytotoxicity against WiTu cells. The results showed higher proportions of WT1-reactive T cells were isolated from Wilms tumor patients compared to healthy donors. WT1-reactive T cells exhibited anti-tumoral activity in a dose-dependent manner and mediated significantly greater cytotoxicity than non-WT1-reactive PBMCs on WT1+ WiTu cells. The cytotoxicity of standard chemotherapy was significantly lower than that of WT1-reactive T cells.
Article
Water Resources
Shushobhit Chaudhary, C. T. Dhanya, Arun Kumar
HYDROLOGY RESEARCH
(2018)
Article
Chemistry, Multidisciplinary
Nathan C. Frey, Hemant Kumar, Babak Anasori, Yury Gogotsi, Vivek B. Shenoy
Article
Chemistry, Physical
Hooman Yaghoobnejad Asl, Jintao Fu, Hemant Kumar, Samuel S. Welborn, Vivek B. Shenoy, Eric Detsi
CHEMISTRY OF MATERIALS
(2018)
Article
Engineering, Multidisciplinary
Arun Kumar, Kaushal Kumar, P. K. Ghosh, Ankit Rathi, K. L. Yadav, Raman
COMPOSITES PART B-ENGINEERING
(2018)
Article
Materials Science, Multidisciplinary
Pooja Kapoor, Arun Kumar, Munish Sharma, Jagdish Kumar, Ashok Kumar, P. K. Ahluwalia
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Dequan Er, Han Ye, Nathan C. Frey, Hemant Kumar, Jun Lou, Vivek B. Shenoy
Article
Chemistry, Physical
Nathan C. Frey, Bryan W. Byles, Hemant Kumar, Dequan Er, Ekaterina Pomerantseva, Vivek B. Shenoy
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2018)
Article
Acoustics
Arun Kumar, Kaushal Kumar, P. K. Ghosh, K. L. Yadav
ULTRASONICS SONOCHEMISTRY
(2018)
Article
Engineering, Environmental
Tropita Piplai, Arun Kumar, Babu J. Alappat
WATER ENVIRONMENT RESEARCH
(2018)
Article
Multidisciplinary Sciences
Hemant Kumar, Janet S. Finer-Moore, Xiaoxu Jiang, Irina Smirnova, Vladimir Kasho, Els Pardon, Jan Steyaert, H. Ronald Kaback, Robert M. Stroud
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Chemistry, Multidisciplinary
Nathan C. Frey, Arkamita Bandyopadhyay, Hemant Kumar, Babak Anasori, Yury Gogotsi, Vivek B. Shenoy
Article
Optics
Qudsia Rubani, Sindhu Hak Gupta, Shuchismita Pani, Arun Kumar
Article
Energy & Fuels
Manish Kumar, Arun Kumar
IEEE JOURNAL OF PHOTOVOLTAICS
(2019)
Article
Engineering, Electrical & Electronic
Emily Porter, Saqib Salahuddin, Alessandra La Gioia, M. Adnan Elahi, Atif Shahzad, Arun Kumar, David Kilroy, M. O'Halloran
IEEE JOURNAL OF ELECTROMAGNETICS RF AND MICROWAVES IN MEDICINE AND BIOLOGY
(2018)
Article
Ecology
Divya Singh, Arun Kumar