A TRPC1 Protein-dependent Pathway Regulates Osteoclast Formation and Function

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

(2013) Noushine Mossadegh-Keller et al.   NATURE

Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development

(2012) Lisa J Robinson et al.   LABORATORY INVESTIGATION

Gated regulation of CRAC channel ion selectivity by STIM1

(2012) Beth A. McNally et al.   NATURE

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1

(2011) Sung-Yong Hwang et al.   FASEB JOURNAL

TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild-type and TRPC1−/− mice

(2011) Jian Shi et al.   FASEB JOURNAL

Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences

(2011) Ivaylo P. Ivanov et al.   NUCLEIC ACIDS RESEARCH

Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions

(2011) Kwong Tai Cheng et al.   PLOS BIOLOGY

RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillations

(2010) Hiroshi Kajiya et al.   CELL CALCIUM

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

(2010) A. Michael Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The role of calcium release activated calcium channels in osteoclast differentiation

(2010) Yandong Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and CaV1.2 Channels

(2010) Y. Wang et al.   SCIENCE

The TRPC Class of Ion Channels: A Critical Review of Their Roles in Slow, Sustained Increases in Intracellular Ca2+ Concentrations

(2009) Lutz Birnbaumer   Annual Review of Pharmacology and Toxicology

Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

(2009) Takako Negishi-Koga et al.   IMMUNOLOGICAL REVIEWS

Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins

(2009) N. Scrimgeour et al.   JOURNAL OF PHYSIOLOGY-LONDON

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

(2009) Karel Otero et al.   NATURE IMMUNOLOGY

STIM protein coupling in the activation of Orai channels

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

TRPV4-Mediated Calcium Influx Regulates Terminal Differentiation of Osteoclasts

(2008) Ritsuko Masuyama et al.   Cell Metabolism

Functional Requirement for Orai1 in Store-operated TRPC1-STIM1 Channels

(2008) Kwong Tai Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

(2008) Y. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA