Factor VIII C1 Domain Spikes 2092–2093 and 2158–2159 Comprise Regions That Modulate Cofactor Function and Cellular Uptake

Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice

(2012) A. Wroblewska et al.   BLOOD

Mass Spectrometry-assisted Study Reveals That Lysine Residues 1967 and 1968 Have Opposite Contribution to Stability of Activated Factor VIII

(2012) Esther Bloem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C1 domain residues Lys 2092 and Phe 2093 are of major importance for the endocytic uptake of coagulation factor VIII

(2011) Henriët Meems et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain

(2011) Eszter Herczenik et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function

(2010) J. Lu et al.   BLOOD

A single lysine of the two-lysine recognition motif of the D3 domain of receptor-associated protein is sufficient to mediate endocytosis by low-density lipoprotein receptor-related protein

(2010) Maartje van den Biggelaar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structural characterization of both the non-proteolytic and proteolytic activation pathways of coagulation Factor XIII studied by hydrogen–deuterium exchange mass spectrometry

(2010) Mette Dahl Andersen et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Factor VIII Lacking the C2 Domain Retains Cofactor Activityin Vitro

(2010) Hironao Wakabayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity

(2009) H. Meems et al.   BLOOD

Purification and characterization of a new recombinant factor VIII (N8)

(2009) L. THIM et al.   HAEMOPHILIA

Intracellular cotrafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles

(2008) M. van den Biggelaar et al.   BLOOD

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

(2008) Jacky Chi Ki Ngo et al.   STRUCTURE