Article
Biology
Graham J. M. Hickey, Candice L. Wike, Xichen Nie, Yixuan Guo, Mengyao Tan, Patrick J. Murphy, Bradley R. Cairns
Summary: This study reveals the order and mechanism of establishing developmental gene poising in zebrafish embryos, highlighting the critical role of H2Aub1.
Article
Environmental Sciences
Mingrui Yuan, Wenhua Li, Peng Xiao
Summary: In this study, exposure to BIX was found to induce cardiac toxicity in zebrafish embryos, leading to cardiac dysplasia and dysfunction. This toxicity was associated with decreased expression of erythropoiesis-related and cardiac development-related genes in response to BIX treatment. These findings highlight the potential environmental risks of BIX exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Shanshan Guo, Yaqing Wu, Wenhua Li, Peng Xiao
Summary: This study aimed to investigate the toxicity of tralomethrin in zebrafish. Results showed that tralomethrin exposure caused cardiovascular dysplasia and dysfunction, as well as developmental abnormalities and oxidative stress in embryos. The dysregulation of crucial genes responsible for cardiovascular development was also observed. These findings highlight the cardiovascular and developmental toxicity of tralomethrin in zebrafish, and their significance for assessing the environmental risk of tralomethrin in aquatic ecosystems.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Shanghong Wang, Xue Han, Tingting Yu, Yulong Liu, Hongying Zhang, Huiling Mao, Chengyu Hu, Xiaowen Xu
Summary: Exposure to isoprocarb induces developmental toxicity, hindbrain defects, and impaired motor ability in zebrafish embryos. The expressions of genes involved in neurodevelopment signaling pathways are inhibited, and oxidative stress is induced, which may be the molecular basis of isoprocarb-induced neurotoxicity in zebrafish embryos.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Anatomy & Morphology
Brian P. Heubel, Carson A. Bredesen, Thomas F. Schilling, Pierre Le Pabic
Summary: Background Endochondral ossification is a major bone forming mechanism in vertebrates, defects in which can result in skeletal dysplasia or craniofacial anomalies in humans. The zebrafish holds great potential to advance our understanding of endochondral growth zone development and genetics, yet several important aspects of its biology remain unexplored. Here we provide a comprehensive description of endochondral growth zones in the pharyngeal skeleton, including their developmental progression, cellular activity, and adult fates. Results Postembryonic growth of the pharyngeal skeleton is supported by endochondral growth zones located either at skeletal epiphyses or synchondroses.Col2a1aandcol10a1ain situ hybridization and anti-PCNA immunostaining identify resting-, hypertrophic- and proliferative zones, respectively, in pharyngeal synchondroses. Cellular hypertrophy and matrix deposition contribute little, if at all, to axial growth in most skeletal elements. Zebrafish endochondral growth zones develop during metamorphosis and arrest in adults. Conclusions Two endochondral growth zone configurations in the zebrafish pharyngeal skeleton produce either unidirectional (epiphyses) or bidirectional (synchondroses) growth. Cell proliferation drives endochondral growth and its modulation, in contrast to mammalian long bones in which bone length depends more on cell enlargement during hypertrophy and intramembranous ossification is the default mechanism of bone growth in zebrafish adults.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Cell Biology
Emmanouil Tsakoumis, Ehsan Pashay Ahi, Monika Schmitz
Summary: This study investigates the role of leptin in the regulation of reproduction in zebrafish. The results demonstrate that leptin is essential for oocyte maturation and ovulation in zebrafish, and deficiency of leptin leads to severe reproductive deficiencies in female zebrafish.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Engineering, Environmental
Zulvikar Syambani Ulhaq, William Ka Fai Tse
Summary: In this study, zebrafish embryos were exposed to PFHxS and it was found that PFHxS accumulated in the embryos, leading to phenotypic abnormalities and disruption of cellular processes. Further analysis revealed that PFHxS affected glucose metabolism, lipid metabolism, and oxidative stress, resulting in increased reactive oxygen species, lipid accumulation, and cell cycle arrest. These findings highlight the potential toxicities of PFHxS.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Jin-Young Lee, Hahyun Park, Whasun Lim, Gwonhwa Song
Summary: The herbicide aclonifen is toxic to experimental animals, causing developmental abnormalities and impaired organogenesis. Mitochondrial dysfunction caused by aclonifen results in various developmental defects in zebrafish embryos, including reduced body length, delayed yolk sac absorption, and disrupted brain and eye formation. This study highlights the importance of understanding the toxicological effects of herbicides in non-target organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Yuanyao Chen, Lin Xiao, Guangyu Gao, Liting He, Kai Zhao, Xuejun Shang, Chunyan Liu
Summary: The disinfection by-product 2, 5-dichloro-1, 4-benuinone (2, 5-DCBQ) exhibits neurodevelopmental toxicity in zebrafish embryos. Exposure to 2, 5-DCBQ resulted in developmental defects and abnormal locomotor activity in zebrafish larvae, with downregulation of genes associated with neuronal development and disruption of neuroactive ligand-receptor interaction and apoptosis pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Bowen Lou, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Ruediger Hell, Hans-Peter Hammes, Julia Szendrodi, Jens Kroll, David Philipp Wohlfart, Chiara Simone Middel, Peter Paul Nawroth
Summary: Reactive carbonyl species (RCS) formed in metabolism can impair the function of DNA, proteins, and lipids, leading to organ complications. This study focuses on the regulation of glucose metabolism, hyperglycemia, and diabetic organ damage by RCS in zebrafish.
Article
Biochemistry & Molecular Biology
Ilaria Gentile, Valeria Vezzoli, Sara Martone, Maria Grazia Totaro, Marco Bonomi, Luca Persani, Federica Marelli
Summary: In this study, we investigated the effects of BaP on the HPG axis in zebrafish embryos. The results showed that BaP compromised the neuronal architecture of the GnRH3 network and upregulated antioxidant activity, oxidative DNA damage, and apoptosis pathways. These findings suggest that short-term exposure to BaP can adversely affect GnRH3 development in zebrafish embryos through a neurotoxic mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Haozhe Qi, Felix Schmoehl, Xiaogang Li, Xin Qian, Christoph T. Tabler, Katrin Bennewitz, Carsten Sticht, Jakob Morgenstern, Thomas Fleming, Nadine Volk, Ingrid Hausser, Elena Heidenreich, Ruediger Hell, Peter Paul Nawroth, Jens Kroll
Summary: The study revealed that acrolein plays a critical role in glucose homeostasis and diabetes development, with impaired acrolein detoxification and elevated ACR concentration serving as biomarkers and inducers for diabetes and diabetic complications.
Article
Environmental Sciences
Hwang-Ju Jeon, Chaeeun Kim, Kyeongnam Kim, Sung-Eun Lee
Summary: Piperlongumine (PL) and piperine (PP), alkaloids found in long pepper, exhibit various biological activities, particularly anti-cancer properties. The toxicities of PL and PP in the environment were assessed using zebrafish embryos. PP showed low mortality and no abnormal phenotype, while PL exhibited strong acute toxicity and abnormal development. The results highlight the need for careful consideration of potential toxicity when developing PL as a medicine.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Jacky Bhagat, Liqing Zang, Satoshi Kaneco, Norihiro Nishimura, Yasuhito Shimada
Summary: The interaction between microplastic/nanoplastic and other environmental contaminants can lead to the accumulation and increased toxicity of metal oxide nanoparticles. This study found that nanoparticles exacerbated oxidative stress and emphasized the importance of monitoring the discharge of these pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Cell Biology
Caitlin Hyland, Michael Mfarej, Giorgos Hiotis, Sabrina Lancaster, Noelle Novak, M. Kathryn Iovine, Matthias M. Falk
Summary: This study investigated the effects of dysregulated Cx43 gap junction endocytosis by deleting a region within the Cx43 CT domain. The deletion caused defective gap junction endocytosis and increased intercellular communication. The findings demonstrate that continuous Cx43 gap junction endocytosis is crucial for gap junction function and impaired endocytosis leads to significant physiological problems, particularly in cardiovascular development and function.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Article
Biochemistry & Molecular Biology
Ying Yang, Lu Wang, Xiao Han, Wen-Lan Yang, Mengmeng Zhang, Hai-Li Ma, Bao-Fa Sun, Ang Li, Jun Xia, Jing Chen, Jian Heng, Baixing Wu, Yu-Sheng Chen, Jia-Wei Xu, Xin Yang, Huan Yao, Jiawei Sun, Cong Lyu, Hai-Lin Wang, Ying Huang, Ying-Pu Sun, Yong-Liang Zhao, Anming Meng, Jinbiao Ma, Feng Liu, Yun-Gui Yang
Article
Cell Biology
Dong Jiang, Zheng Jiang, Di Lu, Xuan Wang, Haisha Liang, Junfeng Zhang, Yaping Meng, Ying Li, Danni Wu, Yuwei Huang, Yuling Chen, Haiteng Deng, Qing Wu, Jingwei Xiong, Anming Meng, Li Yu
NATURE CELL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yonghua Sun, Bo Zhang, Lingfei Luo, De-Li Shi, Han Wang, Zongbin Cui, Honghui Huang, Ying Cao, Xiaodong Shu, Wenqing Zhang, Jianfeng Zhou, Yun Li, Jiulin Du, Qingshun Zhao, Jun Chen, Hanbing Zhong, Tao P. Zhong, Li Li, Jing-Wei Xiong, Jinrong Peng, Wuhan Xiao, Jian Zhang, Jihua Yao, Zhan Yin, Xianming Mo, Gang Peng, Jun Zhu, Yan Chen, Yong Zhou, Dong Liu, Weijun Pan, Yiyue Zhang, Hua Ruan, Feng Liu, Zuoyan Zhu, Anming Meng, Yonghua Sun, Luyuan Pan, Houpeng Wang, Weixun Xie, Mudan He, Ding Ye, Kuoyu Li, Feng Xiong, Liyue Liu, Linglu Li, Yun Zhang, Bo Zhang, Da Liu, Zhenchao Cheng, Yingying Hu, Qian Wu, Zhou Luo, Yutian Zhang, Yingdan Wu, Wenyuan Li, Lingfei Luo, Jianlong Ma, Dashuang Mo, Pengcheng Cai, Jinzi Chen, Junhui Sun, Yang Zhou, Chuan Wu, Rui Ni, De-Li Shi, Ming Shao, Yan-Jun Zhang, Li-Jun Feng, Xiao-Ning Cheng, Ji-Tong Li, Yan-Yi Xing, Yan Zhang, Ya-Ping Meng, Bei-Bei Yu, Han Wang, Jian Huang, Shuqing Zhang, Cheng Ji, Yicheng Tan, Jingjing Wang, Fanmiao Zhang, Mingyong Wang, Guodong Huang, Zhaomin Zhong, Wei Zhang, Zongbin Cui, Yong Long, Guili Song, Xiaohui Li, Xixi Li, Kai Chen, Jing Ren, Junjun Yan, Qing Li, Honghui Huang, Hua Ruan, Shicheng Zhu, Xuejiao Chen, Jingjing Pan, Faming Jiang, Jiehui Chen, Chao Huang, Guoping Dong, Xiaogui Yi, Ying Cao, Ruikun Hu, Weilai Huang, Jiangfang Liu, Hong WangXiao, Dong Shu, Jianhong Xia, Shaoyang Zhao, Pengtao Wang, Xiuhua Wu, Wenqing Zhang, Yiyue Zhang, Mengchang Xu, Wei Liu, Zhibing Huang, Qing Lin, Mei Wu, Jianfeng Zhou, Aibo Sheng, Peipei Tang, Xiaoxia Gong, Wei Mou, Congcong Zu, Yun Li, Ling Lu, Yunzhang Liu, Xiaozhi Rong, Jianyang Chen, Jiulin Du, Jiwen Bu, Xufei Du, Tingting Liu, Shanye Gu, Qingshun Zhao, Zhangji Dong, Xiaohua Dong, Shasha Cao, Yunyun Yue, Chun Gu, Meijing Liu, Jun Chen, Hongjian Gong, Hanbing Zhong, Xuanjun Yang, Jiahao Chen, Qiushi Xu, Tao P. Zhong, Daqin Jin, Peilu She, Jianjian Sun, Kaa Seng Lai, Li Li, Yu Zhang, Yanyan Shi, Fangying Zhao, Jing-Wei Xiong, Meijun Pang, Lu Gao, Lei Lei, Jinrong Peng, Jane Lo, Wuhan Xiao, Xiaolian Cai, Gang Ouyang, Jian Zhang, Weirui Ma, Liyun Miao, Jihua Yao, Yu Hu, Zhan Yin, Xianming Mo, Xue Li, Gang Peng, Cuizhen Zhang, Fenghua Wang, Jun Zhu, Ruimeng Yang, Hao Yuan, Yan Chen, Yi Pan, Yong Zhou, Dong Liu, Feng Zhao, Weijun Pan, Feng Liu, Yanyan Ding, Yuanyuan Xue, Lu Wang, Yifan Zhang, Dongyuan Ma, Xinyan Lu, Shuai Gao, Jun Xia, Zuoyan Zhu, Anming Meng, Xingfeng Liu, Juhui Qiu, Bo Gong, Luxi Chen, Cong Xiong, Likun Yao, Cencan Xing, Yixia Wang, Weimin Shen, Jiawei Sun
Review
Biochemistry & Molecular Biology
Wenwen Lan, Sumin Liu, Long Zhao, Ying Su
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Developmental Biology
Lin Zhang, Luxi Chen, Jing Chen, Weimin Shen, Anming Meng
Article
Developmental Biology
Shunji Jia, Anming Meng
Summary: The TGF beta signaling family is evolutionarily conserved in metazoans and plays diverse roles in embryonic development, adult tissue homeostasis, and human diseases by regulating cell proliferation, differentiation, adhesion, migration, and apoptosis. The molecular mechanisms and key functions of TGF beta subfamily pathways in mesendoderm induction, dorsoventral patterning, laterality development, and tissue/organ formation have been extensively investigated.
Review
Biology
Long Zhao, Feng Gao, Shan Gao, Yujun Liang, Hongan Long, Zhiyi Lv, Ying Su, Naihao Ye, Liusuo Zhang, Chengtian Zhao, Xiaoyu Wang, Weibo Song, Shicui Zhang, Bo Dong
Summary: Evo-Devo seeks to understand how developmental changes impact organismal evolution, but current model organisms may not be sufficient to cover the vast biodiversity on Earth.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Cell Biology
Julienne L. Carstens, Sujuan Yang, Pedro Correa de Sampaio, Xiaofeng Zheng, Souptik Barua, Kathleen M. McAndrews, Arvind Rao, Jared K. Burks, Andrew D. Rhim, Raghu Kalluri
Summary: The study indicates that partial epithelial to mesenchymal transition is associated with metastasis in pancreatic ductal adenocarcinoma (PDAC), and genetic suppression can lead to epithelial stabilization and increased liver metastasis.
Review
Biochemistry & Molecular Biology
Tian Gan, Lixia Fan, Long Zhao, Mala Misra, Min Liu, Min Zhang, Ying Su
Summary: The evolutionarily conserved JNK signaling pathway is essential in determining longevity, with varying effects on lifespan depending on tissue/organ-specific manipulation in Drosophila. Recent studies have shed light on the molecular mechanisms underlying the tissue-specific effects of JNK activity, highlighting the comprehensive role of JNK signaling in regulating lifespan in fruit flies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Bo Gong, Yuting Guo, Shihui Ding, Xiaohui Liu, Anming Meng, Dong Li, Shunji Jia
Summary: Gong et al. discovered the role of the Golgi network in ER-associated endosome fission, showing that a Golgi-derived SEC14L2 compartment plays a crucial role in promoting PtdIns4P to PtdIns3P conversion. Their findings suggest that the Golgi network participates in endosome fission and that ER-endosome contacts regulate endosomal phosphoinositide conversion.
NATURE CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kathleen M. McAndrews, Karina Vazquez-Arreguin, Changsoo Kwak, Hikaru Sugimoto, Xiaofeng Zheng, Bingrui Li, Michelle L. Kirtley, Valerie S. LeBleu, Raghu Kalluri
Summary: The study demonstrates that alpha SMA(+) CAFs in CRC exert tumor-restraining functions via BMP4/TGF beta 1 paracrine signaling that serves to suppress Lgr5(+) CSCs and promote anti-tumor immunity, ultimately limiting CRC progression.
Article
Oncology
Kathleen M. McAndrews, Yang Chen, J. Kebbeh Darpolor, Xiaofeng Zheng, Sujuan Yang, Julienne L. Carstens, Bingrui Li, Huamin Wang, Toru Miyake, Pedro Correa de Sampaio, Michelle L. Kirtley, Mariangela Natale, Chia-Chin Wu, Hikaru Sugimoto, Valerie S. LeBleu, Raghu Kalluri
Summary: The study identifies two distinct populations of fibroblasts with opposing roles in the progression and immune landscape of PDAC. Fibroblasts play diverse functions in regulating cancer-associated pathways and accumulation of regulatory T cells, impacting therapeutic efficacy in PDAC treatment. This finding reveals the functional heterogeneity of CAFs in PDAC progression, with significant implications for therapy response.
Article
Cardiac & Cardiovascular Systems
Alexander A. A. Akerberg, Michael Trembley, Vincent Butty, Asya Schwertner, Long Zhao, Manu Beerens, Xujie Liu, Mohammed Mahamdeh, Shiaulou Yuan, Laurie Boyer, Calum MacRae, Christopher Nguyen, William T. T. Pu, Caroline E. E. Burns, C. Geoffrey Burns
Summary: This study identified RBPMS2 as a key regulator of alternative splicing, myofibrillar organization, and calcium handling in zebrafish and human cardiomyocytes.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dongqing Mo, Chenglin Liu, Yao Chen, Xinkai Cheng, Jie Shen, Long Zhao, Junzheng Zhang
Summary: A study has found that mRpL4, a mitochondrial ribosomal protein, plays a crucial role in the Notch signaling pathway. It is involved in gene transcription during wing development in frogs and has a similar function to human mRpL4. This research reveals a previously unknown function of mRpL4 in animal development.
Review
Marine & Freshwater Biology
Wang Luo, Sumin Liu, Fang Zhang, Long Zhao, Ying Su
Summary: This article reviews the metabolic roles of Drosophila macrophages under homeostasis or stress, emphasizing their critical role in the crosstalk between the immune system and organic metabolism from a Drosophila perspective.
MARINE LIFE SCIENCE & TECHNOLOGY
(2022)