GRK2 Protein-mediated Transphosphorylation Contributes to Loss of Function of μ-Opioid Receptors Induced by Neuropeptide FF (NPFF2) Receptors

Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments

(2011) K Elhabazi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies

(2011) Christian Doll et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons

(2011) Vu C Dang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles

(2011) Enzo R. Porrello et al.   CELLULAR SIGNALLING

Roles of Phosphorylation-dependent and -independent Mechanisms in the Regulation of Histamine H2 Receptor by G Protein-coupled Receptor Kinase 2

(2011) Natalia Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulating μ-Opioid Receptor Phosphorylation Switches Agonist-dependent Signaling as Reflected in PKCϵ Activation and Dendritic Spine Stability

(2011) Hui Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agonist-directed Interactions with Specific β-Arrestins Determine μ-Opioid Receptor Trafficking, Ubiquitination, and Dephosphorylation

(2011) Chad E. Groer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C-Mediated Phosphorylation of the  -Opioid Receptor and Its Effects on Receptor Signaling

(2011) B. Feng et al.   MOLECULAR PHARMACOLOGY

Functional Selectivity at the  -Opioid Receptor: Implications for Understanding Opioid Analgesia and Tolerance

(2011) K. M. Raehal et al.   PHARMACOLOGICAL REVIEWS

Quantitative Encoding of the Effect of a Partial Agonist on Individual Opioid Receptors by Multisite Phosphorylation and Threshold Detection

(2011) E. K. Lau et al.   Science Signaling

Asymmetry of GPCR oligomers supports their functional relevance

(2011) Pascal Maurice et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers

(2010) Anne-Marie Estes et al.   AMINO ACIDS

Opioid-modulating properties of the neuropeptide FF system

(2010) Lionel Moulédous et al.   BIOFACTORS

Quantitative analysis of neuropeptide Y receptor association with β-arrestin2 measured by bimolecular fluorescence complementation

(2010) LE Kilpatrick et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combining resonance energy transfer methods reveals a complex between the α2A-adrenergic receptor, Gαi1β1γ2, and GRK2

(2010) Billy Breton et al.   FASEB JOURNAL

Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling

(2010) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential G-protein-coupled Receptor Phosphorylation Provides Evidence for a Signaling Bar Code

(2010) Adrian J. Butcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In-depth Exploration of Cerebrospinal Fluid by Combining Peptide Ligand Library Treatment and Label-free Protein Quantification

(2010) Emmanuelle Mouton-Barbosa et al.   MOLECULAR & CELLULAR PROTEOMICS

 -Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

(2010) J. McPherson et al.   MOLECULAR PHARMACOLOGY

Modulation by Neuropeptide FF of the interaction of Mu-opioid (MOP) receptor with G-proteins

(2010) Flavie Kersanté et al.   NEUROCHEMISTRY INTERNATIONAL

Modulation of basal and morphine-induced neuronal activity by a NPFF2 selective agonist measured by c-Fos mapping of the mouse brain

(2010) Lionel Moulédous et al.   SYNAPSE

Receptor heteromerization and drug discovery

(2010) Raphael Rozenfeld et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks

(2009) Rachel H Rose et al.   BRITISH JOURNAL OF PHARMACOLOGY

Opioid-receptor-heteromer-specific trafficking and pharmacology

(2009) Richard M van Rijn et al.   CURRENT OPINION IN PHARMACOLOGY

G Protein-coupled Receptor Kinase-2 Constitutively Regulates D2Dopamine Receptor Expression and Signaling Independently of Receptor Phosphorylation

(2009) Yoon Namkung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterodimerization of ORL1 and Opioid Receptors and Its Consequences for N-type Calcium Channel Regulation

(2009) Rhian M. Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 MAPK and β-Arrestin 2 Mediate Functional Interactions between Endogenous μ-Opioid and α2A-Adrenergic Receptors in Neurons

(2009) Miao Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of two novel tritiated radioligands for labelling Neuropeptide FF (NPFF1 and NPFF2) receptors

(2009) Franck Talmont et al.   NEUROCHEMISTRY INTERNATIONAL

Neuropeptide FF-sensitive confinement of mu opioid receptor does not involve lipid rafts in SH-SY5Y cells

(2008) Lionel Moulédous et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction

(2008) M J Christie   BRITISH JOURNAL OF PHARMACOLOGY

Morphine-induced μ-opioid receptor rapid desensitization is independent of receptor phosphorylation and β-arrestins

(2008) Ji Chu et al.   CELLULAR SIGNALLING

EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation

(2008) Yuejun Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

(2008) Andrew B. Tobin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Agonist-selective mechanisms of GPCR desensitization

(2007) E Kelly et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulatory role of neuropeptide FF system in nociception and opiate analgesia

(2007) Hsiu-Ying T. Yang et al.   NEUROPEPTIDES