Poxviral Protein A46 Antagonizes Toll-like Receptor 4 Signaling by Targeting BB Loop Motifs in Toll-IL-1 Receptor Adaptor Proteins to Disrupt Receptor:Adaptor Interactions

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling

(2012) Zhijie Lin et al.   PLoS One

Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α

(2011) Sinead M. Flannery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4

(2011) Celia Bovijn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poxvirus A46 protein binds to TIR domain-containing Mal/TIRAP via an α-helical sub-domain

(2011) Shun-ichiro Oda et al.   MOLECULAR IMMUNOLOGY

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

(2011) E. Valkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different dimerisation mode for TLR4 upon endosomal acidification?

(2011) Monique Gangloff   TRENDS IN BIOCHEMICAL SCIENCES

What the Myddosome structure tells us about the initiation of innate immunity

(2011) Nicholas J. Gay et al.   TRENDS IN IMMUNOLOGY

Cytosolic DNA sensors regulating type I interferon induction

(2011) Sinead E. Keating et al.   TRENDS IN IMMUNOLOGY

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

(2011) Mikayla R. Thompson et al.   Viruses-Basel

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

(2011) Leonie Unterholzner et al.   PLoS Pathogens

Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule

(2010) T. Lysakova-Devine et al.   JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Toll-like Receptor and RIG-1-like Receptor Signaling

(2009) Taro Kawai et al.   Annals of the New York Academy of Sciences

MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses

(2009) Brett Verstak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

The molecular basis of the host response to lipopolysaccharide

(2009) Clare E. Bryant et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

(2009) H. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

(2008) Chong-Shan Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of IκB Kinase by Vaccinia Virus Virulence Factor B14

(2008) Ron A.-J. Chen et al.   PLoS Pathogens

Protective Effect of Toll-like Receptor 4 in Pulmonary Vaccinia Infection

(2008) Martha A. Hutchens et al.   PLoS Pathogens

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

(2008) Stephen C. Graham et al.   PLoS Pathogens