Article
Biology
Ning Xiao, Churong Li, Wenjun Liao, Jun Yin, Shichuan Zhang, Peng Zhang, Lan Yuan, Min Hong
Summary: In this study, it was found that FOXG1 is highly expressed in glioma tissues and can attenuate the radiosensitivity of glioma cells by promoting autophagy. This suggests that FOXG1 may be a key molecule in circumventing radiation-induced cell death in malignant glioma cells and could potentially serve as a target for the treatment of human brain glioma.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Pathology
Junlong Zhuang, Jiange Hao, Fan Bu, Haoli Yin, Wei Chen, Hongqian Guo
Summary: The study found that miR-582 is downregulated in bladder cancer and has a regulatory effect on cell invasion by directly targeting FOXG1, serving as a potential prognostic biomarker.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Medicine, Research & Experimental
Yuanshe Huang, Lai Zhang, Tianlei Liu, E. Liang
Summary: The expression of FOXD1 is upregulated in prostate cancer, and its high expression is associated with clinical stage and survival. It regulates the expression of LMNB1 to promote viability, migration, and invasion of prostate cancer cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Multidisciplinary Sciences
Allison Mitchell, Ling Wu, C. James Block, Mu Zhang, Justin Hackett, Douglas B. Craig, Wei Chen, Yongzhong Zhao, Bin Zhang, Yongjun Dang, Xiaohong Zhang, Shengping Zhang, Chuangui Wang, Heather Gibson, Lori A. Pile, Benjamin Kidder, Larry Matherly, Zhe Yang, Yali Dou, Guojun Wu
Summary: The study reveals that FOXQ1 recruits the MLL/KMT2 histone methyltransferase complex as a transcriptional coactivator to initiate EMT in breast cancer. Disruption of FOXQ1-RbBP5 interaction or pharmacologic targeting of KMT2/MLL recruitment inhibits FOXQ1-dependent gene expression, EMT, and in vivo tumor progression. Targeting the FOXQ1-MLL epigenetic axis could be a promising strategy against metastatic progression in triple-negative breast cancer.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Xin Guan, Aiping Shi, Yabin Zou, Meiyang Sun, Yue Zhan, Yi Dong, Zhimin Fan
Summary: The study revealed that miR-375 plays an important role in breast cancer development, with EZH2 acting as an upstream regulator of miR-375 and FOXO1 as a downstream target mRNA. FOXO1 activates the p53 signaling pathway to suppress breast cancer progression.
FRONTIERS IN GENETICS
(2021)
Article
Fisheries
Yuqi Zhao, Ximei Nie, Zhengxiao Han, Peng Liu, Hao Xu, Xin Huang, Qian Ren
Summary: In this study, a FOXO gene (EsFOXO) from E. sinensis was cloned and its involvement in the immune and metabolic regulation of crabs with hepatopancreatic necrosis disease (HPND) was investigated. The expression of EsFOXO was significantly upregulated in the intestine of crabs with HPND compared to normal crabs. RNA interference analysis showed that EsFOXO positively regulates the expression of pancreatic lipases, anti-lipopolysaccharide factors, and crustins. Our study suggests that crabs with HPND adopt strategies of increased antimicrobial peptide synthesis and upregulated expression of enzymes involved in lipid catabolism to survive under starvation.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Junfeng Ye, Yu Fu, Zhongfeng Wang, Jinhai Yu
Summary: The study found that FOXP4-AS1 promotes the progression of HCC by regulating H3K27me3, suppressing the expression of ZC3H12D, and affecting the biological functions of HCC cells.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Cell & Tissue Engineering
Xiaojun Huang, Xiaoxia Su, Qizhao Ma, Yongting Xie, Qiang Guo, Li Liao, Jing Zou
Summary: The activation of Forkhead box protein O1 (FoxO1) promotes osteogenesis of periodontal ligament stem cells (PDLSCs) and protects their function under inflammatory conditions. Hyperoside or 2-furoyl-LIGRLO-amide trifluoroacetate salt (2-Fly) enhances osteogenic differentiation by inhibiting NF-kappa B activation, beta-catenin expression, and ROS production. Local injection of hyperoside or 2-Fly rescues the expression of FoxO1 and Runx2 in vivo, alleviating alveolar bone loss and periodontal ligament damage. These findings demonstrate the protective effect of FoxO1 agonists on osteogenesis in PDLSCs and their potential for bone regeneration in periodontitis.
STEM CELLS AND DEVELOPMENT
(2023)
Article
Medicine, Research & Experimental
Marutpong Detarya, Salak Thaenkaew, Wunchana Seubwai, Somsiri Indramanee, Chatchai Phoomak, Charupong Saengboonmee, Sopit Wongkham, Chaisiri Wongkham
Summary: High glucose promotes the progression of CCA cells by upregulating FOXM1 expression and activating EGFR/STAT3 pathways.
Article
Medicine, Research & Experimental
Yuan Gu, Jiujin Jiang, Chaozhao Liang
Summary: TFAP4 overexpression in prostate cancer is associated with poor prognosis, promoting cell migration and invasion, and positively regulating FOXK1 expression. Targeting the TFAP4-FOXK1 axis may offer a new approach for clinical therapy in PC.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Virology
Huan Li, Ren Wang, Ze Yu, Run Shi, Jie Zhang, Shanshan Gao, Ming Shao, Shuzhong Cui, Zhenxing Gao, Jiang Xu, Man-Sun Sy, Chaoyang Li
Summary: TNFα can up-regulate PrP expression and promote tumor cell migration through the TNFα-NF-kappa B-FOXP3-SNAP29 signaling axis. FOXP3 and SNAP29 play critical roles in this process.
Article
Oncology
Jian Shi, Jingtian Wang, Hongkun Cheng, Shenghui Liu, Xiaowei Hao, Lili Lan, Gancun Wu, Meng Liu, Yan Zhao
Summary: FOXP4, a member of the FOX family, is significantly upregulated in LSCC tissues and cells and is associated with poor prognosis. It plays a role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition, by directly binding to the promoter of lymphoid enhancer-binding factor 1 and activating the Wnt signaling pathway. These findings suggest potential therapeutic and prognostic targets for LSCC.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Ana Rita Garcia, Avilson Mendes, Carlos Custodia, Claudia C. Faria, Joao T. Barata, Rui Malho, Ines Figueira, Maria Alexandra Brito
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that often metastasizes to the brain, leading to poor prognosis. However, TNBC is associated with overexpression of epidermal growth factor receptor (EGFR) and activation of the PI3K signaling pathway. This study aimed to identify potential drug candidates for TNBC treatment by inhibiting EGFR and/or PI3K. By screening a library of drugs predicted to cross the blood-brain barrier and inhibit EGFR or PI3K, two dual inhibitors emerged as promising candidates to target brain metastatic TNBC cells.
Article
Multidisciplinary Sciences
Jason A. Pfister, Chi Ma, Santosh R. D'Mello
Article
Biology
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A. Parone, Sheue-Houy Tyan, Tsemay M. Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B. Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W. Yeo, Lino Tessarollo, Martin Marsala, Christopher E. Shaw, Greg Tucker-Kellogg, Albert R. La Spada, Clotilde lagier-Tourenne, Sandrine Da Cruz, Don W. Cleveland
Article
Geriatrics & Gerontology
Dao-Fu Dai, Yonggang Liu, Nathan Basisty, Pabalu Karunadharma, Somasish G. Dastidar, Ying Ann Chiao, Tony Chen, Richard P. Beyer, Michael T. Chin, Michael Maccoss, Albert R. La Spada, Peter S. Rabinovitch
Article
Neurosciences
Anto Sam Crosslee Louis Sam Titus, Dharmendra Sharma, Min Soo Kim, Santosh R. D'Mello
Article
Neurosciences
Qiang Zhu, Jie Jiang, Tania F. Gendron, Melissa McAlonis-Downes, Lulin Jiang, Amy Taylor, Sandra Diaz Garcia, Somasish Ghosh Dastidar, Maria J. Rodriguez, Patrick King, Yongjie Zhang, Albert R. La Spada, Huaxi Xu, Leonard Petrucelli, John Ravits, Sandrine Da Cruz, Clotilde Lagier-Tourenne, Don W. Cleveland
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Vincent Soubannier, Gilles Maussion, Mathilde Chaineau, Veronika Sigutova, Guy Rouleau, Thomas M. Durcan, Stefano Stifani
NEUROSCIENCE LETTERS
(2020)
Review
Medicine, Research & Experimental
Santosh R. D'Mello
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Review
Medicine, Research & Experimental
Santosh R. D'Mello, Mark C. Kindy
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Neurosciences
Somasish Ghosh Dastidar, Michael T. Pham, Matthew B. Mitchell, Steven G. Yeom, Sarah Jordan, Angela Chang, Bryce L. Sopher, Albert R. La Spada
JOURNAL OF NEUROSCIENCE
(2020)
Review
Biochemistry & Molecular Biology
Santosh R. D'Mello
Summary: MECP2 duplication syndrome is a rare X-linked genomic disorder that predominantly affects males with no available treatments. It causes neurodegenerative disease leading to neuronal death in specific brain regions, possibly involving dysfunction of astrocytes and neurons.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Santosh R. D'Mello
Summary: Alzheimer's disease and Huntington's disease are characterized by cognitive decline and motor abnormalities respectively, with both conditions involving abnormal actions of common kinases. Research into these kinases may lead to more effective therapeutic approaches for these neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Louise Thiry, Jean-Pierre Clement, Rainer Haag, Timothy E. Kennedy, Stefano Stifani
Summary: This study introduces a cytocompatible dendritic polyglycerol amine (dPGA) substrate-based method for prolonged culture of hiPSC-derived motor neurons (MNs). The improved culture conditions allow better observation of MN morphology, survival, and functional properties, facilitating human disease research. Additionally, a new approach for evaluating mature motor neurons using single-cell RNA sequencing is also presented.
Review
Medicine, Research & Experimental
Santosh R. D'Mello
Summary: Rett syndrome, CDKL5 deficiency disorder, and FOXG1 syndrome are neurodevelopmental disorders with shared neurological features and possibly common molecular mechanisms. This review investigates the role of deregulation of common molecules in neurons and astrocytes in key behavioral and neurological abnormalities in all three disorders.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Neurosciences
Ye Man Tang, Nisha S. Pulimood, Stefano Stifani
Summary: Homeostatic microglia, the resident immune cells in the nervous system, become activated in response to injury/disease. Differentiating human induced pluripotent stem cells (iPSCs) into microglia-like cells allows for the study of neurodegenerative diseases, but different methods result in microglia with distinct transcriptional signatures.
Review
Developmental Biology
Santosh R. D'Mello
DEVELOPMENTAL NEUROSCIENCE
(2020)