Article
Biochemistry & Molecular Biology
Xu Chen, Yuhong Zhang, Xiang Ren, Qi Su, Yan Liu, Xing Dang, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Yajie Shen, Yaya Wang, Zhantao Bai, Edward T. H. Yeh, Hongmei Wu, Yitao Qi
Summary: The study revealed that hyper-SUMOylation of Kv7.2 and Kv7.3 channels can disrupt neuronal membrane excitability regulation, and its interaction with PIP2, CaM1, and retigabine plays crucial roles in the channel function.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Materials Science, Textiles
Na Sun, Chongwen Yu
Summary: A computer simulation model based on fiber arrangement and separation degree was proposed to simulate the fiber arrangement in a sliver. The simulation results showed that this model could accurately simulate the irregularity of the sliver. In the future, the simulation of the fiber separation process and the random combination process can be accomplished based on this model.
JOURNAL OF NATURAL FIBERS
(2022)
Article
Chemistry, Multidisciplinary
Yiyuan Cheng, Xuan Yi, Yan Zhang, Qingli He, Dandan Chen, Weiguo Cao, Pengfei Fang, Wen Liu
Summary: By reconstituting the biosynthetic route of ABCH-containing unit, we found that the formation of ABCH is completed by an oxidase heterotetramer with the association of NRPS. DADH precursor was prepared and offloaded from an amino-group carrier protein. DADH was processed to form an aziridine ring and further cyclized to form a fused five-membered nitrogen heterocycle in the NRPS. The catalytic mechanism of the oxidase heterotetramer was rationalized through biochemical characterization, crystal structure, and site-specific mutagenesis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Xiaoqin Zhan, Chris Drummond-Main, Dylan Greening, Jinjing Yo, S. W. R. Chen, J. P. Appendino, P. Y. Billie Au, Ray W. Turner
Summary: The study reveals that cannabidiol has the ability to reduce the effects of a pathogenic KCNQ variant, which could be a potential therapeutic approach to reduce seizure activity and treat neurodevelopmental disorders.
Article
Polymer Science
Xingyu Yuan, Wen Li, Bin Yao, Zhao Li, Deling Kong, Sha Huang, Meifeng Zhu
Summary: Synthetic vascular grafts made from the polymer PLCL show great promise for directing tissue regeneration. A tri-layered structure composed of a smooth inner layer, circumferentially aligned fibrous middle layer, and randomly distributed fibrous outer layer was successfully prepared using ink printing, wet spinning, and electrospinning techniques. These grafts exhibited kink resistance and mechanical properties equivalent to clinical standard conduits, and showed visible guiding effects on specific vascular cells.
Article
Multidisciplinary Sciences
Fabien Thery, Lia Martina, Caroline Asselman, Heidi Repo, Yifeng Zhang, Koen Sedeyn, George D. Moschonas, Clara Bredow, Qi Wen Teo, Jingshu Zhang, Madeleine Vessely, Kevin Leandro, Denzel Eggermont, Delphine De Sutter, Katie Boucher, Tino Hochepied, Nele Festjens, Nico Callewaert, Xavier Saelens, Bart Dermaut, Klaus-Peter Knobeloch, Antje Beling, Sumana Sanyal, Lilliana Radoshevich, Sven Eyckerman, Francis Impens
Summary: The researchers identify RNF213 as a sensor for ISGylated proteins on the surface of lipid droplets, showing both antiviral properties and the ability to target intracellular bacteria. RNF213, induced by interferon, exhibits broad antimicrobial activity against various infections and oligomerizes on lipid droplets as a sensor for ISGylated proteins.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Youming Zhu, Leu Jin, Ronghua Shi, Jinming Li, Yan Wang, Li Zhang, Chao-Zhao Liang, Vinod K. Narayana, David P. De Souza, Rick F. Thorne, Li Rong Zhang, Xu Dong Zhang, Mian Wu
Summary: This study reveals a novel long noncoding RNA (lncRNA) called gLINC that acts as a backbone for the formation of a metabolon involving glycolytic enzymes and lactate dehydrogenase A. The gLINC metabolon enhances glycolytic flux, ATP production, and cell survival under serine deprivation. Overexpression of gLINC in cancer cells promotes xenograft growth in mice on a serine-deprived diet, suggesting its role in cancer cell adaptation.
Article
Mechanics
Miguel Marco, Eugenio Giner, Maria Henar Miguelez, David Gonzalez
Summary: The study indicates that the randomness of fiber arrangement has a significant impact on damage initiation, with higher randomness leading to earlier damage. In tension loading, normal stress at the fiber interfaces dominates the initiation of damage, while in compression loading, damage is mostly controlled by tangential stress at the interfaces.
COMPOSITE STRUCTURES
(2021)
Article
Biochemistry & Molecular Biology
Subhendu K. Das, Vladislav Kuzin, Donald P. Cameron, Suzanne Sanford, Rajiv Kumar Jha, Zuqin Nie, Marta Trullols Rosello, Ronald Holewinski, Thorkell Andresson, Jan Wisniewski, Toyoaki Natsume, David H. Price, Brian A. Lewis, Fedor Kouzine, David Levens, Laura Baranello
Summary: MYC is directly associated with topoisomerase 1 (TOP1) and TOP2, and it stimulates their activities, leading to increased levels of these enzymes on DNA and promotion of genome function.
Article
Biochemistry & Molecular Biology
Wesley Sanchez, Samuel Lindsay, Yumin Li
Summary: In this study, a full-length model of A1t was generated for the first time and molecular dynamics simulations were performed to assess its structure and dynamics. The simulations revealed the stable binding of the first 11 residues of A1-ND to S100A11 and the flexibility of A1-ND allowed for multiple conformations of A1t. This study provides important insights into the structure and function of Annexin-S100 complexes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Engineering, Multidisciplinary
R. Raveendra Nath, K. Hemachandra Reddy, C. Vijaya Bhaskar Reddy
Summary: The study introduces parallel streams in the Goswami cycle to improve performance, resulting in consistently higher output compared to the conventional cycle. The thermal efficiency and exergy efficiency of the modified cycle show different results compared to the Goswami cycle.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Weiqiang Sun, Guang Hu, Hu Xu, Yanfei Li, Chao Wang, Tingxuan Men, Fu Ji, Wanji Lao, Bo Yu, Liang Sheng, Jinhong Li, Qinggang Jia, Songqi Xiong, Huasi Hu
Summary: This study investigated the influence of the spatial arrangement of functional reinforced particles on the neutron shielding performance of composites. The neutron flux distribution was analyzed in different physical models, and the results showed that the arrangement of B4C particles has an impact on the shielding performance of the composite.
Article
Clinical Neurology
Isamu Aiba, Jeffrey L. Noebels
Summary: The potassium channel subunit Kcnq2/K(v)7.2 has been identified as a key modulatory gene in spreading depolarization, affecting seizure-spreading depolarization transition threshold, bilateral cortical expression, and diurnal susceptibility. Pharmacological intervention or genetic mutations can directly impact the threshold and properties of cortical spreading depolarizations.
Article
Multidisciplinary Sciences
Victor Tobiasson, Ieva Berzina, Alexey Amunts
Summary: Mitoribosomes of green algae exhibit structural divergence from their tracheophyte relatives, with fragmentation of both rRNA and proteins. By analyzing the structure of the mitoribosome from the alga Polytomella magna, researchers identified non-canonical forms of rRNA and peripherally associated proteins involved in binding. These findings suggest an evolutionary pathway and support the concept of a primordial fragmented ribosome. The study provides insights into the evolution of the ribosomal machinery in mitochondria.
NATURE COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Rahul Bandyopadhyay, Abhishek Padhy, Ibrahim Mahariq, Bandaru Ramakrishna, Claudionor G. Bezerra, Carlos H. Costa, Chittaranjan Nayak, Oussama Accouche
Summary: This article investigates the effects of random arrangement of layers, length of the multilayer, and chemical potential of graphene on the robustness of the graphene induced photonic bandgap (GIPBG) in one dimensional graphene-embedded photonic crystals. Numerical results show that the random arrangement and length of the multilayers cause minor changes in the bandgap edge, while the chemical potential strongly affects the robustness of the low frequency GIPBG.
RESULTS IN PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Pia Jeggle, Ewan St. J. Smith, Andrew P. Stewart, Silke Haerteis, Christoph Korbmacher, J. Michael Edwardson
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Meeting Abstract
Biophysics
Shyam Srivats, Dilshan Balasuriya, Mathias Pasche, Robert Vistal, Colin W. Taylor, Mike J. Edwardson, Ruth D. Murrell-Lagnado
BIOPHYSICAL JOURNAL
(2015)
Article
Cell Biology
Qi Cao, Zoe Zhong, Yuanjie Zou, Ruth Murrell-Lagnado, Michael X. Zhu, Xian-Ping Dong
JOURNAL OF CELL BIOLOGY
(2015)
Article
Endocrinology & Metabolism
Iris Hardege, Shengxin Xu, Richard D. Gordon, Andrew J. Thompson, Nichola Figg, Michael Stowasser, Ruth Murrell-Lagnado, Kevin M. O'Shaughnessy
MOLECULAR ENDOCRINOLOGY
(2015)
Article
Neurosciences
Marc-David Ruepp, James A. Brozik, Iwan J. P. de Esch, Richard W. Farndale, Ruth D. Murrell-Lagnado, Andrew J. Thompson
Article
Cell Biology
Shyam Srivats, Dilshan Balasuriya, Mathias Pasche, Gerard Vistal, J. Michael Edwardson, Colin W. Taylor, Ruth D. Murrell-Lagnado
JOURNAL OF CELL BIOLOGY
(2016)
Editorial Material
Physiology
Ruth D. Murrell-Lagnado
JOURNAL OF GENERAL PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Andrew P. Stewart, Richard N. Sandford, Fiona E. Karet Frankl, J. Michael Edwardson
Article
Pharmacology & Pharmacy
Ruth D. Murrell-Lagnado, Manfred Frick
CURRENT OPINION IN PHARMACOLOGY
(2019)
Article
Neurosciences
Paul Beswick, Ben Wahab, Mark A. Honey, Michael Paradowski, Ke Jiang, Martin Lochner, Ruth D. Murrell-Lagnado, Andrew J. Thompson
Article
Biochemistry & Molecular Biology
Sin-Lih Tan, Muruj Barri, Peace Atakpa-Adaji, Colin W. Taylor, Ewan St John Smith, Ruth D. Murrell-Lagnado
Summary: It was found that lysosomal P2X4 receptors are activated downstream of plasma membrane P2X7 and H-1 histamine receptor stimulation. The activation of P2X4 receptors results in an increase in near-lysosome cytosolic [Ca2+] and triggers changes in lysosome properties, including enlargement and redistribution within the cell. The findings suggest that lysosomal P2X4 receptors play a role in regulating lysosomal Ca2+ release and membrane trafficking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Stephanie Chadet, Jordan Allard, Lucie Brisson, Osbaldo Lopez-Charcas, Roxane Lemoine, Audrey Heraud, Stephanie Lerondel, Roseline Guibon, Gaelle Fromont, Alain Le Pape, Denis Angoulvant, Lin-Hua Jiang, Ruth Murrell-Lagnado, Sebastien Roger
Summary: The P2X4 purinergic receptor is upregulated in breast cancer patients and primarily localised in endolysosomes. It promotes breast cancer invasion, tumour growth, and metastasis by regulating lysosome acidity, promoting autophagy and cell survival. It is also associated with epithelial-to-mesenchymal transition and plays a more significant role under metabolic challenges.
Article
Multidisciplinary Sciences
Alexandra M. Riding, Kevin W. Loudon, Andrew Guo, John R. Ferdinand, Laurence S. C. Lok, Nathan Richoz, Andrew Stewart, Tomas Castro-Dopico, Zewen Kelvin Tuong, Remi Fiancette, Georgina S. Bowyer, Aaron Fleming, Eleanor S. Gillman, Ondrej Suchanek, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, David Withers, Gordan Dougan, Simon Clare, Menna R. Clatworthy
Summary: Bladder infection affects a hundred million people annually, but our understanding of bladder immunity is incomplete. Our research found that type 17 immune response genes were highly active in the bladder after exposure to uropathogenic Escherichia coli. Group 3 innate lymphoid cells were identified as the source of cytokines involved in the immune response, and their proliferation post infection contributed to an enhanced immune response in the bladder.
Review
Immunology
Emily Naish, Alexander J. T. Wood, Andrew P. Stewart, Matthew Routledge, Andrew Conway Morris, Edwin R. Chilvers, Katharine M. Lodge
Summary: Neutrophils, the most abundant circulating leukocytes, play a crucial role in the initial innate immune response to infection. They eliminate pathogens through phagocytosis and a complex interplay of multiple systems and mechanisms within the phagosome creates an antimicrobial environment. However, gaps in knowledge and controversies exist regarding how neutrophil phagosomes optimize pathogen killing.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Akimichi Inaba, Zewen Kelvin Tuong, Tian X. X. Zhao, Andrew P. P. Stewart, Rebeccah Mathews, Lucy Truman, Rouchelle Sriranjan, Jane Kennet, Kourosh Saeb-Parsy, Linda Wicker, Frank Waldron-Lynch, Joseph Cheriyan, John A. A. Todd, Ziad Mallat, Menna R. R. Clatworthy
Summary: Activation of B cells expressing CD25 can be enhanced by low-dose recombinant IL-2, leading to increased secretion of IL-10. Administration of low dose IL-2 to patients results in an increase in IL-10-producing B cells. Single-cell RNA sequencing reveals enrichment of regulatory B cell gene signature in plasma cell populations from IL-2-treated patients, with significant down-regulation of the transcriptional repressor BACH2. BACH2 suppression leads to increased B cell IL-10, suggesting its role in promoting an immunoregulatory phenotype in B cells through IL-2 modulation.
NATURE COMMUNICATIONS
(2023)