Review
Transplantation
Wen Wen, Ignacio Portales-Castillo, Rituvanthikaa Seethapathy, Scott Krinsky, Daniela Kroshinsky, Sahir Kalim, Jeremy Goverman, Rosalynn M. Nazarian, Vipul Chitalia, Rajeev Malhotra, Rafael Kramann, Cindy K. Malhotra, Sagar U. Nigwekar
Summary: This study evaluated the effects and safety of intravenous sodium thiosulphate (STS) for vascular calcification (VC) in patients with chronic kidney disease (CKD). The results showed that STS treatment could attenuate the progression of VC and arterial stiffness, with no significant adverse effects observed.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Camilo G. Sotomayor, Stan Benjamens, Antonio W. Gomes-Neto, Robert A. Pol, Dion Groothof, Charlotte A. te Velde-Keyzer, Guillermo Chong, Andor W. J. M. Glaudemans, Stefan P. Berger, Stephan J. L. Bakker, Riemer H. J. A. Slart
Summary: CKD-MBD and vascular calcification are common in kidney transplant recipients. This study found a high prevalence of BMD disorders in KTR, with an independent inverse association between BMD and AAC suggesting the existence of a bone-vascular axis post transplantation.
Review
Nutrition & Dietetics
Jorge B. Cannata-Andia, Natalia Carrillo-Lopez, Osvaldo D. Messina, Neveen A. T. Hamdy, Sara Panizo, Serge L. Ferrari
Summary: Vascular calcification, low bone mass, and fragility fractures are frequently observed in ageing subjects, with potential common mechanisms that need further research to understand their interplay.
Article
Endocrinology & Metabolism
S. Hildebrand, J. Cunningham
Summary: The effects of bisphosphonates on vascular calcification are complex and variable, with no definitive evidence of accelerated vascular calcification. The kidneys play a crucial role in calcium buffering, and decreased GFR may increase the risk of hypercalcemia due to high calcium influx.
Article
Endocrinology & Metabolism
Fengyu Jia, Suxia Wang, Ying Jing, Hanhui Zhao, Peng Rong, Hongbin Zhang, Wenting Lu, Yan Xue, Gang Sun
Summary: The study found a significant elevation of osteocalcin (OC) in MHD patients, positively correlated with phosphorus, iPTH, FGF23, and negatively correlated with age. Age and OC were identified as risk factors for high AACs (>= 5).
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mandy E. Turner, Tyler S. Rowsell, Austin P. Lansing, Paul S. Jeronimo, Lok Hang Lee, Bruno A. Svajger, Jason G. E. Zelt, Corey M. Forster, Martin P. Petkovich, Rachel M. Holden, Michael A. Adams
Summary: The study investigates the systemic response to acute phosphate challenges in the presence of vascular calcification (VC) and highlights the negative vascular consequence of fluctuations in circulating phosphate. The findings emphasize the importance of phosphate bioavailability and diet management in CKD patients as a mediator of cardiovascular risk.
CARDIOVASCULAR RESEARCH
(2023)
Review
Endocrinology & Metabolism
Inge Groenendijk, Marieke van Delft, Pieter Versloot, Luc J. C. van Loon, Lisette C. P. G. M. de Groot
Summary: Higher magnesium intake is positively associated with increased hip and femoral neck bone mineral density in older adults. However, more well-designed cohort studies and randomized controlled trials are needed to further confirm the relationship and whether magnesium supplementation can improve bone health. The combination of multiple bone nutrients may be necessary for optimal effects on bone health and to prevent or delay the development of osteoporosis.
Article
Cardiac & Cardiovascular Systems
Daniele Massera, Petra Buzkova, Anna E. Bortnick, David S. Owens, SongShou Mao, Dong Li, Ian H. De Boer, Bryan R. Kestenbaum, Matthew J. Budoff, Jorge R. Kizer
Summary: Low bone mineral density was modestly associated with increased progression of aortic valve calcification and mitral annular calcification in a multi-ethnic cohort study. The impact of altered bone mineral metabolism on calcific valve disease in the general population was not significant, but may have a more meaningful influence in higher-risk individuals with osteoporosis, requiring further investigation.
Article
Urology & Nephrology
Jingfeng Huang, Lingling Bao, Yuning Pan, Qingqing Lu, Yaqin Huang, Qianjiang Ding, Fangjie Shen, Qiuli Huang, Xinzhong Ruan
Summary: The combination of CACs and vertebral BMD could predict the occurrence of cardiovascular events in MHD patients to some extent.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Hiroko Hashimoto, Satomi Shikuma, Shintaro Mandai, Susumu Adachi, Shinichi Uchida
Summary: In hemodialysis patients, older age, female gender, lower body mass index, diabetes mellitus, and higher Kt/V ratios are associated with increased risk of osteoporosis, while the use of calcium-based phosphate binders (CBPBs) is associated with lower osteoporosis risk, particularly within specific subgroups. This effect may be partially due to calcium supplementation, especially in users of active vitamin D analogs or non-users of proton pump inhibitors (PPIs).
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Emre Sahin, Cemal Orhan, Tansel Ansal Balci, Fusun Erten, Kazim Sahin
Summary: The study found that organic magnesium picolinate (MgPic) is more effective in increasing osteogenic protein levels in bone, preventing bone loss, and promoting bone formation in rats fed with a high-fat diet compared to inorganic magnesium oxide (MgO).
Article
Urology & Nephrology
Li Sun, Zhengkai Huang, Shuang Fei, Bin Ni, Zijie Wang, Hao Chen, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Ruoyun Tan
Summary: Kidney transplant recipients showed progression of vascular calcification (VC) within one year postoperatively, closely related to mineral and bone disorders.
Review
Biochemistry & Molecular Biology
Akos Geza Petho, Mihaly Tapolyai, Maria Browne, Tibor Fulop
Summary: The ongoing critical re-examination of modifiable risk factors in chronic kidney diseases shows that attempts to modulate vascular risk with cholesterol-lowering agents have failed. Pathological biochemical processes and decreased serum magnesium levels contribute to vascular calcification in chronic kidney damage, leading to cardiovascular complications. Simple oral magnesium supplementation may reduce cardiovascular mortality in severely affected patients, and the concept of 'normal' vs. 'ideal' serum magnesium levels needs to be re-evaluated.
Article
Biochemistry & Molecular Biology
Chien-Te Lee, Wei-Hung Kuo, You-Lin Tain, Yi Wang, Wen-Chin Lee
Summary: This study found that exogenous BMP7 administration can improve disturbed CKD-MBD and vascular calcification in adenine-induced chronic uremic rats. The treatment shows potential in alleviating renal dysfunction, hyperphosphatemia, hyperparathyroidism, and skeletal structural abnormalities.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Hanne Skou Jorgensen, Herman Borghs, Sam Heye, Dieter Smout, Kathleen Claes, Pieter Evenepoel
Summary: This study investigated the impact of abdominal aortic calcification on bone mineral density in patients with chronic kidney disease. The findings challenge the traditional belief that measurement of lumbar spine bone mineral density using DXA is unreliable in patients with CKD.