Adeno-Associated Virus-Mediated Rhodopsin Replacement Provides Therapeutic Benefit in Mice with a Targeted Disruption of the Rhodopsin Gene

Overexpression of Rhodopsin Alters the Structure and Photoresponse of Rod Photoreceptors

(2009) Xiao-Hong Wen et al.   BIOPHYSICAL JOURNAL

Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors

(2009) Mei Hong Tan et al.   HUMAN MOLECULAR GENETICS

Improved Retinal Function in a Mouse Model of Dominant Retinitis Pigmentosa Following AAV-delivered Gene Therapy

(2009) Naomi Chadderton et al.   MOLECULAR THERAPY

Comparative Analysis of GPCR Crystal Structures

(2009) David T. Lodowski et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors

(2008) Edwin C.T. Oh et al.   BRAIN RESEARCH

Clinical gene therapy using recombinant adeno-associated virus vectors

(2008) C Mueller et al.   GENE THERAPY

The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors

(2008) Sheila A. Baker et al.   JOURNAL OF CELL BIOLOGY

Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice

(2008) Mariacarmela Allocca et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel AAV serotypes for improved ocular gene transfer

(2008) Corinna Lebherz et al.   JOURNAL OF GENE MEDICINE

Detection of Intact rAAV Particles up to 6 Years After Successful Gene Transfer in the Retina of Dogs and Primates

(2008) Knut Stieger et al.   MOLECULAR THERAPY

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

(2008) A. V. Cideciyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of photoreceptor gene expression by Crx-associated transcription factor network

(2007) Anne K. Hennig et al.   BRAIN RESEARCH

A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa

(2007) Mary O’Reilly et al.   VISION RESEARCH

Versatility of AAV vectors for retinal gene transfer

(2007) Enrico M. Surace et al.   VISION RESEARCH