A Distal Enhancer inIl12bIs the Target of Transcriptional Repression by the STAT3 Pathway and Requires the Basic Leucine Zipper (B-ZIP) Protein NFIL3

NFIL3/E4BP4 is a key transcription factor for CD8 + dendritic cell development

(2011) M. Kashiwada et al.   BLOOD

Anti-IL-23 Monoclonal Antibody Synergizes in Combination with Targeted Therapies or IL-2 to Suppress Tumor Growth and Metastases

(2011) M. W. L. Teng et al.   CANCER RESEARCH

NFIL3/E4BP4 controls type 2 T helper cell cytokine expression

(2011) Masaki Kashiwada et al.   EMBO JOURNAL

A Polymorphism in the Coding Region of Il12b Promotes IL-12p70 and IL-23 Heterodimer Formation

(2011) A. Zwiers et al.   JOURNAL OF IMMUNOLOGY

NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity

(2011) T. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

(2011) Yasutaka Motomura et al.   NATURE IMMUNOLOGY

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

IL-10 inhibits transcription elongation of the humanTNFgene in primary macrophages

(2010) Tim Smallie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

(2010) Nobuhisa Mizuki et al.   NATURE GENETICS

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract

(2010) Daniel R Engel et al.   NATURE MEDICINE

Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors

(2010) B. Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis

(2010) M. W. L. Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine Usage in Mycobacteria-Infected Macrophages Depends on Autocrine-Paracrine Cytokine Signaling

(2010) J. E. Qualls et al.   Science Signaling

Ustekinumab: Lessons Learned from Targeting Interleukin-12/23p40 in Immune-Mediated Diseases

(2009) Michael Elliott et al.   Annals of the New York Academy of Sciences

Regulatory T Cells Reinforce Intestinal Homeostasis

(2009) Michael J. Barnes et al.   IMMUNITY

Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans

(2009) Lyudmila Lyakh et al.   IMMUNOLOGICAL REVIEWS

Interleukin (IL)-23 mediatesToxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

(2009) Melba Muñoz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

(2009) Shintaro Kamizono et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Isolation of Toxoplasma gondii development mutants identifies a potential proteophosphogylcan that enhances cyst wall formation

(2009) Mary Patricia J. Craver et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development

(2009) Duncan M Gascoyne et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching

(2009) M. Kashiwada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

(2008) Ana Izcue et al.   IMMUNITY

Cytokine Signaling Modules in Inflammatory Responses

(2008) John J. O'Shea et al.   IMMUNITY

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

(2008) Karim C El Kasmi et al.   NATURE IMMUNOLOGY

Detecting shared pathogenesis from the shared genetics of immune-related diseases

(2008) Alexandra Zhernakova et al.   NATURE REVIEWS GENETICS