Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C

Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

(2008) F. George Njoroge et al.   ACCOUNTS OF CHEMICAL RESEARCH

Effects of Mutagenic and Chain-Terminating Nucleotide Analogs on Enzymes Isolated from Hepatitis C Virus Strains of Various Genotypes

(2008) J. A. Heck et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

(2008) J. Paeshuyse et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Viral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI)

(2008) Peter Borowski et al.   BIOCHEMICAL PHARMACOLOGY

RNA Unwinding Activity of the Hepatitis C Virus NS3 Helicase Is Modulated by the NS5B Polymerase†

(2008) Thomas A. Jennings et al.   BIOCHEMISTRY

Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors

(2008) A. V. Mukovnya et al.   BIOCHEMISTRY-MOSCOW

New acridone-4-carboxylic acid derivatives as potential inhibitors of Hepatitis C virus infection

(2008) Anna Stankiewicz-Drogon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Monitoring helicase activity with molecular beacons

(2008) Craig A. Belon et al.   BIOTECHNIQUES

Novel Hepatitis C Drugs in Current Trials

(2008) Bernd Kronenberger et al.   Clinics in Liver Disease

Recent progress in the development of selected hepatitis C virus NS3·4A protease and NS5B polymerase inhibitors

(2008) A KWONG et al.   CURRENT OPINION IN PHARMACOLOGY

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

(2008) Dahai Luo et al.   EMBO JOURNAL

Hepatitis C Virus NS3 Helicase Forms Oligomeric Structures That Exhibit Optimal DNA Unwinding Activityin Vitro

(2008) Bartek Sikora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NS3 Helicase from the Hepatitis C Virus Can Function as a Monomer or Oligomer Depending on Enzyme and Substrate Concentrations

(2008) Thomas A. Jennings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase

(2008) Rudolf K. F. Beran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase

(2008) Victor Serebrov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NS3 Helicase Domains Involved in Infectious Intracellular Hepatitis C Virus Particle Assembly

(2008) Y. Ma et al.   JOURNAL OF VIROLOGY

Acute hepatitis C

(2008) Anurag Maheshwari et al.   LANCET

Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex

(2008) V. Brass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA