Article
Biochemistry & Molecular Biology
Sheila B. Powers, Nourhan G. Ahmed, Roslin Jose, Marissa Brezgiel, Subhash Aryal, W. Paul Bowman, Porunelloor A. Mathew, Stephen O. Mathew
Summary: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with B-cell ALL being more prevalent and T-cell ALL being more aggressive. The study showed increased expression of LLT1 in B-ALL and T-ALL patients. Surface LLT1 expression was significantly increased in T cells, monocytes, and NK cells of ALL patients. The study also observed increased expression of CS1 and NKp46 on monocytes at the diagnosis of ALL. Post-induction chemotherapy, there was a decrease in LLT1, 2B4, CS1, and NKp46 expression on T cells of ALL patients. The findings suggest that the differential expression of these receptors/ligands may play a role in T-cell- and NK-cell-mediated immune surveillance of pediatric ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Hannah M. Szafraniec, Jose M. Valdez, Elizabeth Iffrig, Wilbur A. Lam, John M. Higgins, Philip Pearce, David K. Wood
Summary: Characterization of blood flow rheology in hematological disorders is crucial for understanding disease pathophysiology. In this study, a new method combining microfluidic systems and object-tracking computational technologies was developed to separate the flow profile of red blood cells in patients with sickle cell disease (SCD) into different components. The results showed that blood from SCD patients had elevated frictional and viscous resistances at all physiological oxygen tensions. The method also revealed patient variability in blood properties and its impact on transfusion treatments.
Article
Immunology
Abigail G. Harvey, Athens M. Graves, Chandana K. Uppalapati, Saoirse M. Matthews, Stephanie Rosenberg, Emma G. Parent, Madison H. Fagerlie, Jack Guinan, Brina S. Lopez, Lisa M. Kronstad
Summary: Influenza viruses cause a significant amount of disease and death. The interaction between dendritic cells (DC) and natural killer (NK) cells has been found to play an important regulatory role in T cell response during influenza infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Studies
Nurul Dhewani Mirah Sjafrie, Pramaditya Wicaksono, Udhi E. Hernawan, Doddy M. Triyono, Doddy M. Yuwono, Muhammad Hafizt, Novi Susetyo Adi, Rohani Ambo-Rappe, Bayu Prayudha, Muhammad Banda Selamat, Sofia Yunia Sani, Setiawan Djody Harahap, Huwaida Nur Salsabila, Jennifer Wijaya, Chris Roelfsema
Summary: This study assessed the availability of seagrass-related data and the roles of stakeholders at a national level in Indonesia. The results showed that the extent and percent cover of seagrass were the most crucial data needed, and stakeholders prioritized the use of seagrass data for coastal management. However, there was a lack of coordination among stakeholders in data provisioning, highlighting the need for strengthened data governance.
Article
Oncology
Xin Li, Mengping Chen, Yike Wan, Lu Zhong, Xiaofeng Han, Xiaotong Chen, Fei Xiao, Jia Liu, Yiwei Zhang, Di Zhu, Jing Xiang, Junling Liu, Honghui Huang, Jian Hou
Summary: Our study reveals that NK cell exhaustion in MM is associated with distinct transcriptomic features, including downregulation of activating receptors and cytolytic molecules and upregulation of inhibitory receptors. We identify ZNF683 as a transcriptional suppressor that directly binds to the promoter of SH2D1B, leading to downregulation of this gene and impaired NK cell cytotoxic activity.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Priyanka Rawat, Asmita Das
Summary: NK cells play important immune functions in autoimmune diseases and successful pregnancies, providing immunity against viral infections and tumors. They are distributed in various organs and exhibit functional differences due to the regulation of transcription factors.
Article
Biology
Sabela Rodriguez-Lorenzo, Lynn van Olst, Carla Rodriguez-Mogeda, Alwin Kamermans, Susanne M. A. van der Pol, Ernesto Rodriguez, Gijs Kooij, Helga E. de Vries
Summary: In this study, the immune landscape of periventricular brain regions in patients with MS was analyzed using single-cell mass cytometry (CyTOF). The results showed the accumulation of CD56(bright) NK cells in the brain regions of MS patients, bringing NK cells back into the spotlight of MS pathology.
Article
Endocrinology & Metabolism
Encarnacion Torres, Inmaculada Velasco, Delphine Franssen, Violeta Heras, Francisco Gaytan, Silvia Leon, Victor M. Navarro, Rafael Pineda, M. Luz Candenas, Antonio Romero-Ruiz, Manuel Tena-Sempere
Summary: The study explored the role of NK2R in the neuroendocrine control of the reproductive axis using a novel Tacr2 knockout mouse model. Results showed that NK2R stimulation elicited LH responses in mice, with partial suppression of basal and stimulated LH secretion in Tacr2 knockout mice, impacting LH pulsatility and breeding intervals. NK2R plays a modest role in the gonadotropic axis, overlapping with other tachykinin receptors.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Uriel Y. Moreno-Nieves, Joshua K. Tay, Saumyaa Saumyaa, Nina B. Horowitz, June Ho Shin, Imran A. Mohammad, Bogdan Luca, David C. Mundy, Gunsagar S. Gulati, Nikita Bedi, Serena Chang, Chen Chen, Michael J. Kaplan, Eben L. Rosenthal, F. Christopher Holsinger, Vasu Divi, Fred M. Baik, Davud B. Sirjani, Andrew J. Gentles, Aaron M. Newman, Aharon G. Freud, John B. Sunwoo
Summary: Despite the reported antitumor functions of NK cells, their contribution to tumor control in humans remains controversial due to incomplete understanding of the NK cell states within the tumor microenvironment (TME). This study demonstrates that peripheral circulating NK cells differentiate into two divergent pathways within the TME, resulting in different end states, with one having potent in vivo antitumor activity. This finding provides insight into the origin of certain NK cell states within the TME and identifies specific NK cell phenotypes with the greatest antitumor activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Yi Wei, Xiang Gao, Aihua Li, Mengjun Liang, Zongpei Jiang
Summary: This study utilized CellPhoneDB for cell cross-talk analysis and revealed associations between cell communication-related genes and renal function, offering new insights into cell communication in diabetic kidney disease (DKD).
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Tom M. J. Evers, Vahid Sheikhhassani, Marielle C. Haks, Cornelis Storm, Tom H. M. Ottenhoff, Alireza Mashaghi
Summary: The mechanical behavior of monocytes is strain rate dependent and can be altered by chemokines. Understanding the mechanical properties of monocytes can provide physical biomarkers for disease progression and response to therapy.
Article
Dermatology
Yumei Gao, Fengjie Liu, Jingru Sun, Yujie Wen, Ping Tu, Marshall E. Kadin, Yang Wang
Summary: SATB1 expression is associated with clinicopathological characteristics in MF, with high expression correlating with favorable prognosis and low expression potentially linked to poor outcomes. SATB1 may influence pathology and outcomes in MF patients by regulating gene expression and immune activation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Honghui Zeng, Le Wang, Jiajia Li, Siweier Luo, Qianqian Han, Fang Su, Jing Wei, Xiaona Wei, Jianping Wu, Bin Li, Jingang Huang, Patrick Tang, Chunwei Cao, Yiming Zhou, Qiongqiong Yang
Summary: By conducting single-cell RNA-sequencing analysis, it was found that the number and cytotoxicity of NK cells in IgAN patients were significantly reduced, a B cell subset exhibited suppression of NF kappa B signaling, and a monocyte subset expressing interferon-induced genes was positively associated with disease severity.
CELL AND BIOSCIENCE
(2021)
Article
Multidisciplinary Sciences
Lilong Liu, Yaxin Hou, Changqi Deng, Zhen Tao, Zhaohui Chen, Junyi Hu, Ke Chen
Summary: This study identifies CD39 as a potential therapeutic target for bladder cancer through single-cell RNA sequencing and validates its inhibitory effect on tumor growth and improvement of overall survival in vivo. The findings confirm the potential importance of CD39 as an immune therapy target for bladder cancer.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Eric D. Salomaki, Kristina X. Terpis, Sonja Rueckert, Michael Kotyk, Zuzana Kotykova Varadinova, Ivan Cepicka, Christopher E. Lane, Martin Kolisko
Summary: Apicomplexan lineages exhibit diverse functional restructuring of mitochondrial metabolism, likely driven by adaptations to parasitism and anaerobiosis. Our findings suggest that apicomplexans have evolved convergent adaptations, sharing characteristics such as morphology, energy metabolism, and intracellular lifestyle.
Article
Biochemistry & Molecular Biology
Alexander J. Davies, Hyoung Woo Kim, Rafael Gonzalez-Cano, Jahyang Choi, Seung Keun Back, Seung Eon Roh, Errin Johnson, Melanie Gabriac, Mi-Sun Kim, Jaehee Lee, Jeong Eun Lee, Yun Sook Kim, Yong Chul Bae, Sang Jeong Kim, Kyung-Mi Lee, Heung Sik Na, Priscilla Riva, Alban Latremoliere, Simon Rinaldi, Sophie Ugolini, Michael Costigan, Seog Bae Oh
Article
Multidisciplinary Sciences
Kwon-Ho Song, Se Jin Oh, Suyeon Kim, Hanbyoul Cho, Hyo-Jung Lee, Joon Seon Song, Joon-Yong Chung, Eunho Cho, Jaeyoon Lee, Seunghyun Jeon, Cassian Yee, Kyung-Mi Lee, Stephen M. Hewitt, Jae-Hoon Kim, Seon Rang Woo, Tae Woo Kim
NATURE COMMUNICATIONS
(2020)
Review
Biochemistry & Molecular Biology
Min Hwa Shin, Jiyoung Kim, Siyoung A. Lim, Jeongsoo Kim, Kyung-Mi Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Yeon Sik Choi, Jahyun Koo, Young Joong Lee, Geumbee Lee, Raudel Avila, Hanze Ying, Jonathan Reeder, Leonhard Hambitzer, Kyungtaek Im, Jungwon Kim, Kyung-Mi Lee, Jianjun Cheng, Yonggang Huang, Seung-Kyun Kang, John A. Rogers
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Cell Biology
Suyeon Kim, Hanbyoul Cho, Soon-Oh Hong, Se Jin Oh, Hyo-Jung Lee, Eunho Cho, Seon Rang Woo, Joon Seon Song, Joon-Yong Chung, Sung Wook Son, Sang Min Yoon, Yu-Min Jeon, Seunghyun Jeon, Cassian Yee, Kyung-Mi Lee, Stephen M. Hewitt, Jae-Noon Kim, Kwon-Ho Song, Tae Woo Kim
Summary: The emergence of refractory phenotypes in tumor cells is associated with an aberrant autophagic state induced by NANOG, leading to resistance to CTLs. Upregulation of LC3B by NANOG increases EGF secretion, resulting in hyperactivation of EGFR-AKT signaling and resistance to CTL killing. The LC3B-p-EGFR axis is a central molecular target for controlling immune-refractory cancer and inhibition of LC3B can render tumors susceptible to immune therapies.
Article
Immunology
Jeong Rae Yoo, Tae-Jin Kim, Sang Taek Heo, Kyung-Ah Hwang, Hyunjoo Oh, TaeHong Ha, Hye Kyung Ko, Seungjae Baek, Ju Eun Kim, Jun Hyeong Kim, Jiin Lee, Min Ji Kang, Mi Soo Yoo, Jung Mogg Kim, Kyung-Mi Lee, Keun Hwa Lee
Summary: In this study, it was found that various biomarkers and inflammatory factors were higher in patients with fatal SFTS than in those with nonfatal disease during the initial clinical course. Additionally, IL-6 and IL-10 levels were strongly correlated with outcomes in SFTSV-infected patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Dongeon Kim, Mingyo Kim, Tae Woo Kim, Yong-ho Choe, Hae Sook Noh, Hyun Min Jeon, HyunSeok Kim, Youngeun Lee, Gayeong Hur, Kyung-Mi Lee, Kihyuk Shin, Sang-il Lee, Seung-Hyo Lee
Summary: LN-TRCs trans-present IL-2 to naive CD4(+) T cells through CD25, regulating CD4(+) T cell differentiation and immune responses. Reduced CD25 expression on LN-TRCs exacerbates autoimmune phenotypes by enhancing Th17 cell differentiation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hyo-Jung Lee, Kwon-Ho Song, Se Jin Oh, Suyeon Kim, Eunho Cho, Jungwon Kim, Yun Gyu Park, Kyung-Mi Lee, Cassian Yee, Seung-Hwa Song, Suhwan Chang, Jungmin Choi, Sang Taek Jung, Tae Woo Kim
Summary: The study reveals that Translationally controlled tumor protein (TCTP) is a factor that affects immunotherapeutic resistance and is associated with the clinical outcome of anti-PD-L1 therapy. Targeting TCTP can enhance the efficacy of T cell-mediated anti-tumor therapy.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Hyungsin Kim, Jeongsoo Kim, Jason K. Sa, Byung-Kyu Ryu, Kyung-Jae Park, Jiyoung Kim, Hyojeong Ha, Yejin Park, Min Hwa Shin, Jungwon Kim, Hyemin Lee, Daham Kim, Kyunghye Lee, Byunghyun Jang, Kyung-Mi Lee, Shin-Hyuk Kang
Summary: Calcipotriol, a synthetic vitamin D analog, can overcome the immune evasion of glioblastoma multiforme by modulating immune responses and the immunosuppressive tumor microenvironment. It activates CD8+T and NK cells while reducing regulatory T cells, leading to inhibition of tumor growth.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Hyun-Ah Kim, Hyunsoo Kim, Min-Kyung Nam, Jong Kook Park, Moo-Yeal Lee, Seok Chung, Kyung-Mi Lee, Hyo-Jeong Kuh
Summary: This study investigated the effect of activated pancreatic stellate cells (aPSCs) on NK cell-mediated anticancer efficacy and established a TIME-on-chip model based on PANC-1 tumor spheroids, aPSCs, and NK-92 cells.
CANCER CELL INTERNATIONAL
(2023)
Article
Virology
Su Yeon Kang, Jeong Rae Yoo, Yejin Park, So-Hee Kim, Sang Taek Heo, Seong Hyeon Park, Misun Kim, Tae-Jin Kim, Songhyeok Oh, Moo-Seung Lee, Jung Mogg Kim, Nam-Hyuk Cho, Kyung-Mi Lee, Keun Hwa Lee
Summary: This study found that levels of IL-10 and IL-6 were significantly elevated, and the level of TGF-beta was significantly decreased in severe and critical COVID-19 and fatal SFTS patients. IL-10 was elevated earlier than IL-6. Inhibition of IL-10 signaling decreased the production of IL-6 and elevated that of TGF-beta. IL-10 and IL-6 hyperproduction and low TGF-beta production have been linked to cytokine storm-induced mortality in fatal SFTS and severe and critically ill COVID-19 patients, and IL-10 plays an important role in the host immune response to severe SARS-CoV-2 and fatal SFTSV infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Bonggoo Park, Min Hwa Shin, Jiyoung Kim, Gayoung Park, Yun-Kyoung Ryu, Jae-Wook Lee, Tae Jin Kim, Eun-Yi Moon, Kyung-Mi Lee
Summary: Thymosin beta-4 (T beta 4) plays a key role in acute pulmonary infections and systemic sepsis caused by Legionella pneumophila, providing effective resistance through bactericidal and anti-inflammatory pathways.
INFECTION AND IMMUNITY
(2021)
Article
Pharmacology & Pharmacy
Bo-Ram Lee, Hyo-Jung Lee, June Huh, Chul Joo Yoon, Se Jin Oh, Kwon-Ho Song, Sojin Jeong, Jungwon Kim, Kyung-Mi Lee, Beom Soo Shin, Ji Hoon Jeong, Tae Woo Kim, Jeewon Lee
Summary: An innovative platform for adjuvant- and antibody-free cancer immunotherapy using human heavy chain ferritin (huHF)-derived structures presenting tumor-specific antigens (TSAs) or immune checkpoint molecules (ICMs) has been reported. Through structure-guided molecular design, TSA-presenting huHFs target TSAs at dendritic cells while preserving huHF-intrinsic affinity for transferrin receptors, and multi-copies of an ICM are presented on huHF for blocking a specific regulatory IC. This novel approach effectively activates TSA-specific CD8+ T cells, suppresses tumor growth and interleukin 17+ CD4+ T cell responses, and generates long-lasting protective immunity, promising a breakthrough in cancer immunotherapy.
ADVANCED THERAPEUTICS
(2021)
Review
Immunology
Min Hwa Shin, Junghee Kim, Siyoung A. Lim, Jungwon Kim, Seong-Jin Kim, Kyung-Mi Lee
Article
Oncology
Hye Yeon Choi, Gwang-Mo Yang, Ahmed Abdal Dayem, Subbroto Kumar Saha, Kyeongseok Kim, Youngbum Yoo, Kwonho Hong, Jin-Hoi Kim, Cassian Yee, Kyung-Mi Lee, Ssang-Goo Cho
BREAST CANCER RESEARCH
(2019)