Article
Plant Sciences
Shuai Zhao, Daihong Wan, Yaoyao Zhong, Xiwei Xu
Summary: This study reveals the protective effects of 1,25-D3 against H. pylori-induced apoptosis in gastric mucosa epithelial cells and elucidates its underlying mechanisms.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jonas Schroer, Davide Warm, Federico De Rosa, Heiko J. Luhmann, Anne Sinning
Summary: During early brain development, the BAX/BCL-2 pathway plays a role in regulating cortical neuron removal, with electrical activity serving as a set point of regulation. The upregulation of BAX and downregulation of BCL-2 during the first postnatal week result in a high BAX/BCL-2 ratio, contributing to neuronal death rates. Pharmacological blockade of activity leads to upregulation of Bax, while elevated activity leads to increased BCL-2 expression, indicating the modulation of BAX/BCL-2 expression by electrical activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Environmental Sciences
Abdullah Aslan, Seda Beyaz, Ozlem Gok, Gozde Parlak, Muhammed Ismail Can, Can Ali Agca, Ibrahim Hanifi Ozercan, Akif Evren Parlak
Summary: This study aimed to investigate whether royal jelly can prevent fluoride-induced brain tissue damage and explore the underlying molecular mechanisms. The results showed that royal jelly prevented brain tissue damage caused by fluoride through its antioxidant activities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Medicinal
Aysegul Kucuk, Yucel Polat, Aydan Kilicarslan, Nuran Sungu, Hakan Kartal, Ali Dogan Dursun, Mustafa Arslan
Summary: This study evaluated the effects of irisin in a murine model of hind limb ischemia reperfusion injury. Results showed that irisin can reduce oxidative stress levels and decrease inflammation, demonstrating a protective effect on skeletal muscle in I/R injury.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cell Biology
Ming Jiang, Yinshan Fang, Yu Li, Huachao Huang, Zichen Wei, Xia Gao, Hoon-Ki Sung, Jim Hu, Li Qiang, Jian Ruan, Qixuan Chen, Dianhua Jiang, Jeffrey A. Whitsett, Xingbin Ai, Jianwen Que
Summary: The study reveals an unexpected role of VEGFa/KDR signaling in defending against mucous metaplasia, potentially offering a therapeutic target for common airway pathologies.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Romain Rozier, Rachel Paul, Blandine Madji Hounoum, Elodie Villa, Rana Mhaidly, Johanna Chiche, Els Verhoeyen, Sandrine Marchetti, Ashaina Vandenberghe, Marc Raucoules, Michel Carles, Jean-Ehrland Ricci
Summary: The study identified that sevoflurane-induced anesthetic preconditioning protects cardiomyocytes from ischemia/reperfusion-induced death by inducing mild reactive oxygen species (ROS) production, activating Akt, and inducing the expression of anti-apoptotic protein Bcl-xL. Additionally, the study demonstrated that metformin could mimic this protective signaling pathway, suggesting its potential as a pharmacological preconditioning agent to prevent I/R injuries.
Article
Multidisciplinary Sciences
Doris L. LaRock, Anders F. Johnson, Shyra Wilde, Jenna S. Sands, Marcos P. Monteiro, Christopher N. LaRock
Summary: This study found that the major human pathogen group A Streptococcus secretes a protease virulence factor, SpeB, that induces GSDMA-dependent pyroptosis. GSDMAs can act independently of host regulators as direct sensors of exogenous proteases. The results indicate the critical role of GSDMA in the immune defense against invasive skin infections by GAS.
Article
Multidisciplinary Sciences
Fatima Cairrao, Cristiana C. Santos, Adrien Le Thomas, Scot Marsters, Avi Ashkenazi, Pedro M. Domingos
Summary: This study reveals that the mRNA binding protein Pumilio in fruit flies can protect Xbp1 mRNA from the non-canonical endoribonuclease activity of Ire1 by binding to it. The phosphorylation of Pumilio is crucial for its stabilization of Xbp1 mRNA.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yi Zhu, Junhui Li, Pengpeng Zhang, Bo Peng, Cai Li, Yingzi Ming, Hong Liu
Summary: This study found that berberine has a protective effect against liver ischemia-reperfusion injury by inhibiting a novel circRNA, circDNTTIP2. This finding provides potential treatment strategies and targets for liver ischemia-reperfusion injury.
Article
Neurosciences
Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C. Schoendorf, Melanie Schmitt, Juergen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E. Ehrnhoefer
Summary: Intraneuronal aggregates of the microtubule binding protein Tau, which are modified by phosphorylation and proteolytic cleavage, are associated with neurodegenerative diseases such as Alzheimer's disease. This study identifies two caspase-2 cleavage sites on Tau, D65 and D421, and shows that caspase-2-generated Tau fragments have increased aggregation potential in vitro. However, these fragments do not accumulate in vivo, likely due to efficient clearance through ubiquitination and degradation mediated by CHIP. Overall, these findings highlight the importance of CHIP-induced ubiquitination in the clearance of caspase-2 generated Tau fragments.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Xue-qi Liu, Ling Jiang, Yuan-yuan Li, Yue-bo Huang, Xue-ru Hu, Wei Zhu, Xian Wang, Yong-gui Wu, Xiao-ming Meng, Xiang-ming Qi
Summary: Wogonin has been shown to alleviate glomerulopathy and podocyte injury in diabetic kidney disease (DKD) by regulating the Bcl-2-mediated crosstalk between autophagy and apoptosis. The study also demonstrated the inhibitory effects of wogonin on cellular damage and apoptosis induced by high glucose, as well as its promotion of autophagy in podocytes.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Donglin Yang, Liujun He, Shuiqing Ma, Shiqiang Li, Yajun Zhang, Chunsheng Hu, Jiuhong Huang, Zhigang Xu, Dianyong Tang, Zhongzhu Chen
Summary: Compound 6d, a spiroindoline compound, inhibits CRC growth by acting as an inhibitor of Bcl-2 and inducing caspase 3-mediated intrinsic apoptosis. Caspase 3 activation by compound 6d directly cleaves HDAC6, with cleavage occurring at D1088 in the DMAD-S motif. Compound 6d-induced apoptosis promotes autophagy initiation by disrupting the interaction between Bcl-2 and Beclin 1, resulting in the accumulation of ubiquitinated proteins and reduction of autophagic flux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lisa Goers, Kyungsub Kim, Teagan C. Stedman, Patrick J. Canning, Xiangyu Mou, Nadja Heinz Ernst, Jorn Coers, Cammie F. Lesser
Summary: GBPs enhance CASP4 activation by interacting with LPS, promoting pyroptosis. Shigella inhibits CASP4-mediated cell death through the cooperation of OspC3 and IpaH9.8. The inhibition of GBPs by IpaH9.8 leads to increased LPS release and promotes CASP4 activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Medicinal
Robert B. Kargbo
Summary: The BCL-2 protein family members, such as BCL-2, BCL-XL, and MCL-1, have shown promise as therapeutic targets for cancer treatment, exemplified by the FDA approval of venetoclax in 2016. Scientists are actively working on designing analogs with improved pharmacokinetics and pharmacodynamics. This Patent Highlight presents PROTAC compounds that effectively and selectively degrade BCL-2, offering potential applications in cancer treatment, autoimmune disorders, and immune system diseases.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Yu-Kai Huang, Kun-Che Chang, Chia-Yang Li, Ann-Shung Lieu, Chih-Lung Lin
Summary: This study investigated the role of AKR1B1 in glioma cell proliferation and apoptosis signaling. AKR1B1 expression was measured in different cell lines and tissues. The effects of AKR1B1 overexpression or knockdown, as well as p38 MAPK activation and inhibition, were evaluated. AKR1B1 was found to regulate glioma cell proliferation through the activation of p38 MAPK and apoptosis signaling. Therefore, AKR1B1 may be a potential therapeutic target for glioma therapy.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amaravadhi Harikishore, Ho Sup Yoon
CURRENT MOLECULAR PHARMACOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Chengbin Yang, Nishtha Panwar, Yucheng Wang, Butian Zhang, Maixian Liu, Huiting Toh, Ho Sup Yoon, Swee Chuan Tjin, Peter Han Joo Chong, Wing-Cheung Law, Chih-Kuang Chen, Ken-Tye Yong
Article
Biochemistry & Molecular Biology
Ajit Prakash, Joon Shin, Sreekanth Rajan, Ho Sup Yoon
NUCLEIC ACIDS RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Ajit Prakash, Sreekanth Rajan, Ho Sup Yoon
Article
Chemistry, Physical
Chengbin Yang, Kok Ken Chan, Wen-Jen Lin, Alana Mauluidy Soehartono, Guimiao Lin, Huiting Toh, Ho Sup Yoon, Chih-Kuang Chen, Ken-Tye Yong
Article
Optics
Hamid Farrokhi, Jeeranan Boonruangkan, Byung Jae Chun, Thazhe Madam Rohith, Abhinay Mishra, Hui Ting Toh, Ho Sup Yoon, Young-Jin Kim
Article
Chemistry, Multidisciplinary
Xumeng Wu, Yu Jia Tan, Hui Ting Toh, Lan Huong Nguyen, Shu Hui Kho, Sing Yian Chew, Ho Sup Yoon, Xue-Wei Liu
Article
Plant Sciences
Geeta Kumari, Ka Ho Wong, Aida Serra, Joon Shin, Ho Sup Yoon, Siu Kwan Sze, James P. Tam
Article
Biotechnology & Applied Microbiology
Serap Beldar, Malathy Sony Subramanian Manimekalai, Nam-Joon Cho, Kwanghee Baek, Gerhard Gruber, Ho Sup Yoon
JOURNAL OF GENERAL VIROLOGY
(2018)
Article
Chemistry, Medicinal
Sebastian Pomplun, Claudia Sippel, Andreas Haehle, Donald Tay, Kensuke Shima, Alina Klages, Can Murat Uenal, Benedikt Riess, Hui Ting Toh, Guido Hansen, Ho Sup Yoon, Andreas Bracher, Peter Preiser, Jan Rupp, Michael Steinert, Felix Hausch
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Yeen Shian Ngow, Sreekanth Rajan, Hong Ye, Ho Sup Yoon
Article
Chemistry, Physical
Qingling Ouyang, Xueling Feng, Shuangyang Kuang, Nishtha Panwar, Peiyi Song, Chengbin Yang, Guang Yang, Xinya Hemu, Gong Zhang, Ho Sup Yoon, James P. Tam, Bo Liedberg, Guang Zhu, Ken-Tye Yong, Zhong Lin Wang
Article
Multidisciplinary Sciences
Tae-Yoon Park, Yongwoo Jang, Woori Kim, Joon Shin, Hui Ting Toh, Chun-Hyung Kim, Ho Sup Yoon, Pierre Leblanc, Kwang-Soo Kim
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Sreekanth Rajan, Yongwoo Jang, Chun-Hyung Kim, Woori Kim, Hui Ting Toh, Jeha Jeon, Bin Song, Aida Serra, Julien Lescar, Jun Yeob Yoo, Serap Beldar, Hong Ye, Congbao Kang, Xue-Wei Liu, Melissa Feitosa, Yeahan Kim, Dabin Hwang, Geraldine Goh, Kah-Leong Lim, Hye Min Park, Choong Hwan Lee, Sungwhan F. Oh, Gregory A. Petsko, Ho Sup Yoon, Kwang-Soo Kim
NATURE CHEMICAL BIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Hanjie Jonathan Gan, Amaravadhi Harikishore, Jihye Lee, Sangeun Jeon, Sreekanth Rajan, Ming Wei Chen, Jun Long Neo, Seungtaek Kim, Ho Sup Yoon
Summary: MERS, caused by a coronavirus, has a high mortality rate and lacks specific treatments. Research has found that montelukast sodium hydrate (MSH), an FDA-approved anti-asthma drug, can inhibit MERS-CoV infection, potentially serving as a candidate for therapeutic development against MERS-CoV infections.
ANTIVIRAL RESEARCH
(2021)