Article
Multidisciplinary Sciences
Linh T. Trinh, Anna B. Osipovich, Leesa Sampson, Jonathan Wong, Chris V. E. Wright, Mark A. Magnuson
Summary: The expression of Sox17 gene is crucial for the differentiation of both endothelial and endodermal cells. The study reveals that two evolutionarily conserved promoter regions (CRs) have different roles in regulating the Sox17 gene. Deletion of CR1 only has a modest effect on lympho-vasculogenesis, while deletion of CR2 impairs both vascular and endodermal development.
Article
Multidisciplinary Sciences
Laura Jardine, Simone Webb, Issac Goh, Mariana Quiroga Londono, Gary Reynolds, Michael Mather, Bayanne Olabi, Emily Stephenson, Rachel A. Botting, Dave Horsfall, Justin Engelbert, Daniel Maunder, Nicole Mende, Caitlin Murnane, Emma Dann, Jim McGrath, Hamish King, Iwo Kucinski, Rachel Queen, Christopher D. Carey, Caroline Shrubsole, Elizabeth Poyner, Meghan Acres, Claire Jones, Thomas Ness, Rowen Coulthard, Natalina Elliott, Sorcha O'Byrne, Myriam L. R. Haltalli, John E. Lawrence, Steven Lisgo, Petra Balogh, Kerstin B. Meyer, Elena Prigmore, Kirsty Ambridge, Mika Sarkin Jain, Mirjana Efremova, Keir Pickard, Thomas Creasey, Jaume Bacardit, Deborah Henderson, Jonathan Coxhead, Andrew Filby, Rafiqul Hussain, David Dixon, David McDonald, Dorin-Mirel Popescu, Monika S. Kowalczyk, Bo Li, Orr Ashenberg, Marcin Tabaka, Danielle Dionne, Timothy L. Tickle, Michal Slyper, Orit Rozenblatt-Rosen, Aviv Regev, Sam Behjati, Elisa Laurenti, Nicola K. Wilson, Anindita Roy, Berthold Goettgens, Irene Roberts, Sarah A. Teichmann, Muzlifah Haniffa
Summary: Research demonstrates that the full blood and immune cell repertoire in fetal bone marrow is established within a short 6-7 week period in early second trimester, promoting rapid and extensive diversification of myeloid cells, with distinct differences from fetal liver.
Article
Cell Biology
Fangfang Wang, Zhang Dan, Hongmei Luo, Jingcao Huang, Yushan Cui, Hong Ding, Juan Xu, Zhimei Lin, Yuhan Gao, Xinyu Zhai, Yan Yang, Ying Qu, Li Zhang, Fengjiao Chen, Qiang Wang, Xin Wang, Yu Feng, Ting Liu, Qing Yi, Ting Niu, Yuhuan Zheng
Summary: Drug-resistance is a major problem in multiple myeloma (MM) patients. This study reveals that activated-leukocyte-cell-adhesion-molecule (ALCAM) regulates MM side population (SP)-mediated drug-resistance through the ALCAM-EGF/EGFR axis. EGFR activation promotes the SP ratio, while ALCAM inhibits EGFR downstream signaling in MM cells. SP MM cells have a higher number of mitochondria and interference of mitochondrial function inhibits SP-genesis. Combination therapy with an anti-MM agent and EGFR inhibitor gefitinib improves MM therapeutic efficacy and prolongs survival in MM-bearing mice.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Zili Li, Fang Fang, Yuting Long, Qian Zhao, Xiaotong Wang, Zhen Ye, Tianqing Meng, Xiuli Gu, Wenpei Xiang, Chengliang Xiong, Honggang Li
Summary: Through the use of hESCs model, this study found that TET proteins and NANOG play different roles in human hPGC specification compared to mice. TET proteins stimulate the expression of SOX17 through the NODAL signaling pathway and directly regulate NANOG expression at the onset of hPGCLC induction. DNMT3B-mediated hypermethylation in TKO hESCs inhibits the activation of relevant genes and SOX17/NANOG, leading to the repression of hPGCLC induction. Knockout of DNMT3B partially restores the NODAL signaling pathway and the expression of SOX17/NANOG, rescuing hPGCLC induction.
CELL AND BIOSCIENCE
(2022)
Article
Plant Sciences
Xiao-Xiang Li, Ze-Yu Li, Wan Zhu, Ying-Qi Wang, Yue-Rong Liang, Kai-Rong Wang, Jian-Hui Ye, Jian-Liang Lu, Xin-Qiang Zheng
Summary: Recently, there has been increased attention on the purple tea cultivars with unique purple-colored leaves. These cultivars are enriched with anthocyanin, which provides a new perspective for studying the metabolic flux of flavonoids in tea plants. This review aims to summarize the latest progress on the composition and accumulation of anthocyanins in tea plants, with discussions on the regulation mechanism and a proposed hypothetical model for leaf color transformation during growth. Novel insights presented in this review will facilitate future in-depth studies of purple tea, providing a theoretical basis for targeted breeding programs in leaf color.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Richard Huang, Jalna Meens, Scott Yuzwa, Laurie Ailles, Michael Ohh, Claire M. Robinson
Summary: Cancer stem cells play an important role in tumor biology. This study aimed to identify the existence of clear cell renal cell carcinoma (ccRCC) stem cells using the side population approach, but the results did not support the presence of cancer stem cells in ccRCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Chokdee Wongborisuth, Sukanya Chumchuen, Orapan Sripichai, Usanarat Anurathaphan, Nuankanya Sathirapongsasuti, Duantida Songdej, Amornrat Tangprasittipap, Suradej Hongeng
Summary: This study found that ZNF802 may act as a transcriptional repressor of the gamma-globin gene in adult erythroid cells. Deficiency in ZNF802 induced induction of HBG expression and increased HbF levels in beta(0)-thalassemia/hemoglobinE erythroblasts.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Hugo C. Olguin
Summary: The ubiquitin-proteasome system is an important regulator of stem cell function and plays critical roles in the biology of satellite cells, responsible for muscle maintenance and regeneration. It controls key transcriptional regulators and participates in the regulation of satellite cell stemness and regenerative capacity more broadly.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Susumu Ohya, Junko Kajikuri, Hiroaki Kito, Miki Matsui
Summary: The up-regulation of CYP3A4 is responsible for the acquisition of doxorubicin resistance in cancer spheroid models. The inhibition of K(Ca)1.1 overcomes doxorubicin resistance by reducing the transcription level of CYP3A4 mainly through the Akt-Nrf2-CEBPB axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Automation & Control Systems
Xueying Shao, Yihong Ding
Summary: Differential evolution is a global search algorithm that proposes an improved method based on covariance matrix to increase population diversity and improve convergence speed. This method shows better performance compared to other algorithms in optimizing problems in CEC2017.
Article
Multidisciplinary Sciences
Alena Kalinina, Catherine Gnyra, Vera Tang, Yingben Xue, Diane C. Lagace
Summary: The use of DNA-binding dyes in stem cell research is significant for isolating specific cell populations. In this study, a distinct side population of cells was identified in the mouse brain using a DNA-binding dye, and these cells showed sensitivity to ABC transporter inhibitors. Furthermore, the majority of these cells expressed CD31 and were not adult neural stem cells.
Article
Multidisciplinary Sciences
Xiaoli Dong, Yingying Wei, Tao Xu, Xiaoyue Tan, Na Li
Summary: Cancer stem cells (CSCs) play a crucial role in tumor growth, metastasis, and recurrence. Techniques such as staining tumor cells with Hoechst 33342 and analyzing the proportion of side population (SP) cells using flow cytometry provide convenient, fast, and cost-effective methods for the identification and purification of CSCs. Data generated from these assays can contribute to a better understanding of the stemness properties of tumor cells in response to various signals.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Computer Science, Information Systems
Zhenyu Meng, Yuxin Zhong, Cheng Yang
Summary: This paper introduces a Cooperative Strategy based Differential Evolution (CS-DE) algorithm with enhanced population diversity, utilizing two similar mutation strategies to tackle complex black-box optimization problems. Experimental results demonstrate the competitiveness of the CS-DE algorithm with several state-of-the-art DE variants on the CEC2013 and CEC2014 test suites.
INFORMATION SCIENCES
(2021)
Review
Genetics & Heredity
Mohsen Rashid, Leila Rostami Zadeh, Behzad Baradaran, Ommoleila Molavi, Zeinab Ghesmati, Mehdi Sabzichi, Fatemeh Ramezani
Summary: Hypoxia inducible factor-1 alpha (HIF-1 alpha) plays a crucial role in cancer progression, functioning differently in cells depending on oxygen levels. Targeting HIF-1 alpha and its downstream signaling molecules is a potential strategy for modulating cancer development and progression. Inhibitors of HIF-1 alpha and agents that suppress mTOR, PI3k/Akt, and MAPK pathways could be effective in cancer treatment.
Article
Medicine, General & Internal
Guoju Li, Yuhan Xing, Guolan Wang, Jun Zhang, Qin Wu, Wei Ni, Na Jiao, Wenjing Chen, Qing Liu, Li Gao, Zhenhong Zhang, Yao Wang, Quansheng Xing
Summary: The study revealed a negative association between maternal pre-pregnancy low BMI and macrosomia, with varying protective effects based on maternal age and parity. Low BMI showed the most prominent protective effect against macrosomia in nulliparous mothers aged 35 years and above, and multiparous mothers younger than 25 years old.
Article
Biochemical Research Methods
Juliane W. Schott, Nico M. Jaeschke, Dirk Hoffmann, Tobias Maetzig, Matthias Ballmaier, Tamaryin Godinho, Toni Cathomen, Axel Schambach
Letter
Hematology
Matthias Ballmaier, Wolfgang Holter, Manuela Germeshausen
Letter
Hematology
Matthias Ballmaier, Wolfgang Holter, Manuela Germeshausen
Article
Hematology
Ilenia Simeoni, Jonathan C. Stephens, Fengyuan Hu, Sri V. V. Deevi, Karyn Megy, Tadbir K. Bariana, Claire Lentaigne, Sol Schulman, Suthesh Sivapalaratnam, Minka J. A. Vries, Sarah K. Westbury, Daniel Greene, Sofia Papadia, Marie-Christine Alessi, Antony P. Attwood, Matthias Ballmaier, Gareth Baynam, Emilse Bermejo, Marta Bertoli, Paul F. Bray, Loredana Bury, Marco Cattaneo, Peter Collins, Louise C. Daugherty, Remi Favier, Deborah L. French, Bruce Furie, Michael Gattens, Manuela Germeshausen, Cedric Ghevaert, Anne C. Goodeve, Jose A. Guerrero, Daniel J. Hampshire, Daniel P. Hart, Johan W. M. Heemskerk, Yvonne M. C. Henskens, Marian Hill, Nancy Hogg, Jennifer D. Jolley, Walter H. Kahr, Anne M. Kelly, Ron Kerr, Myrto Kostadima, Shinji Kunishima, Michele P. Lambert, Ri Liesner, Jose A. Lopez, Rutendo P. Mapeta, Mary Mathias, Carolyn M. Millar, Amit Nathwani, Marguerite Neerman-Arbez, Alan T. Nurden, Paquita Nurden, Maha Othman, Kathelijne Peerlinck, David J. Perry, Pawan Poudel, Pieter Reitsma, Matthew T. Rondina, Peter A. Smethurst, William Stevenson, Artur Szkotak, Salih Tuna, Christel van Geet, Deborah Whitehorn, David A. Wilcox, Bin Zhang, Shoshana Revel-Vilk, Paolo Gresele, Daniel B. Bellissimo, Christopher J. Penkett, Michael A. Laffan, Andrew D. Mumford, Augusto Rendon, Keith Gomez, Kathleen Freson, Willem H. Ouwehand, Ernest Turro
Review
Genetics & Heredity
Alessandra Balduini, Hana Raslova, Christian A. Di Buduo, Alessandro Donada, Matthias Ballmaier, Manuela Germeshausen, Carlo L. Balduini
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2018)
Article
Genetics & Heredity
Alessandro Pecci, Catherine Klersy, Paolo Gresele, Kieran J. D. Lee, Daniela De Rocco, Valeria Bozzi, Giovanna Russo, Paula G. Heller, Giuseppe Loffredo, Matthias Ballmaier, Fabrizio Fabris, Eloise Beggiato, Walter H. A. Kahr, Nuria Pujol-Moix, Helen Platokouki, Christel Van Geet, Patrizia Noris, Preethi Yerram, Cedric Hermans, Bernhard Gerber, Marina Economou, Marco De Groot, Barbara Zieger, Erica De Candia, Vincenzo Fraticelli, Rogier Kersseboom, Giorgina B. Piccoli, Stefanie Zimmermann, Tiziana Fierro, Ana C. Glembotsky, Fabrizio Vianello, Carlo Zaninetti, Elena Nicchia, Christiane Guethner, Carlo Baronci, Marco Seri, Peter J. Knight, Carlo L. Balduini, Anna Savoia
Letter
Immunology
Tim Niehues, Tuba Turul Oezguer, Marie Bickes, Rebecca Waldmann, Jennifer Schoening, Jan Braesen, Christian Hagel, Matthias Ballmaier, Jan-Henning Klusmann, Alexandra Niedermayer, Ulrich Pannicke, Anselm Enders, Gregor Dueckers, Kathrin Siepermann, Julyia Hempel, Klaus Schwarz, Dorothee Viemann
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Clinical Neurology
Nicole Moschny, Kirsten Jahn, Hannah Benedictine Maier, Abdul Qayyum Khan, Matthias Ballmaier, Kyra Liepach, Mareike Sack, Thomas Skripuletz, Stefan Bleich, Helge Frieling, Alexandra Neyazi
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Microbiology
Sebastian J. Theobald, Christoph Kreer, Sahamoddin Khailaie, Agnes Bonifacius, Britta Eiz-Vesper, Constanca Figueiredo, Michael Mach, Marija Backovic, Matthias Ballmaier, Johannes Koenig, Henning Olbrich, Andreas Schneider, Valery Volk, Simon Danisch, Lutz Gieselmann, Meryem Seda Ercanoglu, Martin Messerle, Constantin von Kaisenberg, Torsten Witte, Frank Klawonn, Michael Meyer-Hermann, Florian Klein, Renata Stripecke
Article
Psychiatry
Nicole Moschny, Kirsten Jahn, Malek Bajbouj, Hannah Benedictine Maier, Matthias Ballmaier, Abdul Qayyum Khan, Christoph Pollak, Stefan Bleich, Helge Frieling, Alexandra Neyazi
FRONTIERS IN PSYCHIATRY
(2020)
Article
Biology
Srinu Tumpara, Matthias Ballmaier, Sabine Wrenger, Mandy Koenig, Matthias Lehmann, Ralf Lichtinghagen, Beatriz Martinez-Delgado, Elena Korenbaum, David DeLuca, Nils Jedicke, Tobias Welte, Malin Fromme, Pavel Strnad, Jan Stolk, Sabina Janciauskiene
Summary: Expression levels of CX3CR1 on immune cells play a significant role in maintaining tissue homeostasis under physiological and pathological conditions. Recent studies suggest that misfolded proteins, such as polymers or amyloid fibrils, can regulate CX3CR1 expression, providing evidence for involvement in Z-AAT-related disorders. This highlights the importance of understanding the role of misfolded proteins in regulating CX3CR1.
Article
Hematology
Manuela Germeshausen, Matthias Ballmaier
Summary: CAMT is a rare inherited bone marrow failure syndrome characterized by mutations in the MPL gene. The disease has complex etiologies, with associations with radio-ulnar synostosis and the possibility of misdiagnosis with other IBMFS.
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Tamar Kapanadze, Jens P. Bankstahl, Alexander Wittneben, Wolfgang Koestner, Matthias Ballmaier, Jaba Gamrekelashvili, Kashyap Krishnasamy, Anne Limbourg, Tobias L. Ross, Geerd-Juergen Meyer, Hermann Haller, Frank M. Bengel, Florian P. Limbourg
Article
Hematology
Manuela Germeshausen, Phil Ancliff, Jaime Estrada, Markus Metzler, Eva Ponstingl, Horst Ruetschle, Dirk Schwabe, Richard H. Scott, Sule Unal, Angela Wawer, Bernward Zeller, Matthias Ballmaier
Meeting Abstract
Biotechnology & Applied Microbiology
J. W. Schott, D. Hoffmann, N. M. Jaeschke, T. Maetzig, M. Ballmaier, T. Godinho, F. J. Mueller, T. Cathomen, A. Schambach
HUMAN GENE THERAPY
(2015)
