Article
Cell Biology
Linlin Ying, Hao Wu, Shuaishuai Zhou, Han Lu, Manyi Ding, Bo Wang, Shanshan Wang, Yanjun Mao, Fenglin Xiao, Yao Li
Summary: The experiment aimed to investigate the Toll-like receptor signaling pathway of quercetin regulating avian beta-defensin (AvBD) in the ileum of Arbor Acre (AA) broilers. The results showed that dietary supplementation with quercetin significantly decreased the mortality rate of broilers and had a positive impact on the intestinal microecological balance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Matthew R. Chang, Luke Tomasovic, Natalia A. Kuzmina, Adam J. Ronk, Patrick O. Byrne, Rebecca Johnson, Nadia Storm, Eduardo Olmedillas, Yixuan J. Hou, Alexandra Schafer, Sarah R. Leist, Longping V. Tse, Hanzhong Ke, Christian Coherd, Katrina Nguyen, Maliwan Kamkaew, Anna Honko, Quan Zhu, Galit Alter, Erica Ollmann Saphire, Jason S. McLellan, Anthony Griffiths, Ralph S. Baric, Alexander Bukreyev, Wayne A. Marasco
Summary: Monoclonal antibodies are a promising treatment for COVID-19, but the emergence of new variants poses challenges to their efficacy. This study shows that engineering human single-chain antibody fragments against the SARS-CoV-2 spike protein into bispecific antibodies can enhance neutralizing activity against variants of concern.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Alexander Moeller, Saskia-Larissa Jauch-Speer, Shrey Gandhi, Thomas Vogl, Johannes Roth, Olesja Fehler
Summary: The S100A8/A9 heterocomplex is a widely expressed damage-associated molecular pattern, and it interacts with various receptors including TLR4, RAGE, CD33, CD68, CD69, and CD147. However, the exact mode of action and which receptors are involved in the inflammatory response of myeloid immune cells are still unclear. In this study, the authors used CRISPR/Cas9 to delete CD33, CD68, CD69, and CD147 in ER-Hoxb8 monocytes and compared their response to S100A8 and S100A9 with TLR4 knockout monocytes. The results showed that TLR4 is the dominant receptor for the S100-induced inflammatory activation of monocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jacob H. L. Thomas, Liang Lui, Andrew Abell, William Tieu, Andrew A. Somogyi, Juliana E. Bajic, Mark R. Hutchinson
Summary: The study found that reducing TLR signaling pathway can enhance acute analgesic effects, but only male TIR8 deficient mice showed less morphine analgesia. TLR2 and TLR4 deficient mice can prevent analgesic tolerance, but MyD88 animals cannot. Withdrawal behaviors are only protected in TLR2(-/-) mice.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Makoto Kurano, Yoshifumi Morita, Yuki Nakano, Rin Yokoyama, Takuya Shimura, Chungen Qian, Fuzhen Xia, Fan He, Liang Zheng, Hiroko Ohmiya, Yoshiro Kishi, Jun Okada, Naoyuki Yoshikawa, Kazuki Nakajima, Yutaka Nagura, Hitoshi Okazaki, Daisuke Jubishi, Kyoji Moriya, Yasuyuki Seto, Fumihiko Yasui, Michinori Kohara, Masatoshi Wakui, Takeshi Kawamura, Tatsuhiko Kodama, Yutaka Yatomi
Summary: This study investigated the antibody responses to SARS-CoV-2 in Japanese individuals with COVID-19. The results showed differences in antibody responses between Japanese and Western populations. IgA antibodies were the first to appear after infection, and IgG and/or IgA seroconversion often preceded IgM seroconversion. The duration of IgG responses to viral proteins and responses of all three antibody classes to S1 and RBD were longer compared to IgA/IgM responses to viral proteins and responses of all three antibody classes to NCP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Virology
Sugandha Raj, Ayumi Matsuyama-Kato, Mohammadali Alizadeh, Nitish Boodhoo, Eva Nagy, Samira Mubareka, Khalil Karimi, Shahriar Behboudi, Shayan Sharif
Summary: This study investigated the potential transmission of H9N2 avian influenza virus through feces in chickens. It found that the virus can persist in feces and transmit to healthy chickens. Additionally, administration of specific drugs can reduce virus shedding and enhance interferon expression, thus improving antiviral immunity.
Article
Immunology
Chattip Sripatumtong, Tunsuda Tansit, Papapit Tuchinda, Duangjit Kanistanon, Kanokvalai Kulthanan, Yuttana Srinoulprasert
Summary: The association between chronic spontaneous urticaria (CSU) and autoimmunity has been confirmed. We developed a validated ELISA method to quantitate IgG anti-Fc epsilon R1 autoantibodies in CSU patients.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Asmaa M. Zahran, Hanaa Nafady-Hego, Eman Askar, Heba M. Elmasry, Ismail L. Mohamad, Osama M. El-Asheer, Asmaa M. Esmail, Khalid I. Elsayh
Summary: Alterations in the proportions and expression of TLR-2 and TLR-4 in monocyte subsets may play a significant role in the pathogenesis of early stages of T1DM and DKA.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
X. Li, Q. Li, W. Ruan
Summary: Differences in Toll-like receptors 3 and 7 (TLR3 and TLR7) can affect the host's resistance to RNA viral infection. By analyzing the sequences of TLR3 and TLR7 in 64 avian species, multiple mutation sites were identified, some of which may impact recognition and play crucial roles in viral recognition. These findings suggest that positive selection has occurred in avian TLR3 and TLR7 genes.
BRAZILIAN JOURNAL OF POULTRY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Yuichi Ozaki, Manabu Kashiwagi, Toshio Imanishi, Yosuke Katayama, Akira Taruya, Tsuyoshi Nishiguchi, Yasutsugu Shiono, Akio Kuroi, Takashi Yamano, Takashi Tanimoto, Hironori Kitabata, Atsushi Tanaka
Summary: Upregulation of Toll-like receptor 4 (TLR-4) is associated with coronary plaque vulnerability. Computed tomography-adapted Leaman score (CT-LeSc) serves as a long-term predictor of cardiac events. This study investigates the relationship between TLR-4 expression on CD14(++)CD16(+) monocytes and future cardiac events in patients with coronary artery disease (CAD).
CORONARY ARTERY DISEASE
(2023)
Article
Allergy
F. Ramadani, N. Upton, P. Hobson, Y. -C. Chan, D. Mzinza, H. Bowen, C. Kerridge, B. J. Sutton, D. J. Fear, H. J. Gould
Article
Allergy
E. Gadermaier, L. K. James, M. H. Shamji, K. Blatt, K. Fauland, P. Zieglmayer, T. Garmatiuk, M. Focke-Tejkl, M. Villalba, R. Beavil, W. Keller, P. Valent, S. R. Durham, H. J. Gould, S. Flicker, R. Valenta
Article
Allergy
T. S. Dodev, H. Bowen, M. H. Shamji, H. J. Bax, A. J. Beavil, J. M. McDonnell, S. R. Durham, B. J. Sutton, H. J. Gould, L. K. James
Article
Chemistry, Multidisciplinary
Christopher Cozens, Hannes Mutschler, Geoffrey M. Nelson, Gillian Houlihan, Alexander I. Taylor, Philipp Holliger
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2015)
Review
Allergy
P. Campo, C. Rondon, H. J. Gould, E. Barrionuevo, P. Gevaert, M. Blanca
CLINICAL AND EXPERIMENTAL ALLERGY
(2015)
Article
Biochemical Research Methods
Alexander I. Taylor, Philipp Holliger
Article
Allergy
F. Ramadani, H. Bowen, N. Upton, P. S. Hobson, Y. -C. Chan, J. -B. Chen, T. W. Chang, J. M. McDonnell, B. J. Sutton, D. J. Fear, H. J. Gould
Article
Allergy
Jiun-Bo Chen, Louisa K. James, Anna M. Davies, Yu-Chang Bryan Wu, Joanne Rimmer, Valerie J. Lund, Jou-Han Chen, James M. McDonnell, Yih-Chih Chan, George H. Hutchins, Tse Wen Chang, Brian J. Sutton, Harsha H. Kariyawasam, Hannah J. Gould
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Timothy Recaldin, Philip S. Hobson, Elizabeth H. Mann, Faruk Ramadani, David J. Cousins, Paul Lavender, David J. Fear
MOLECULAR IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Alexander I. Taylor, Vitor B. Pinheiro, Matthew J. Smola, Alexey S. Morgunov, Sew Peak-Chew, Christopher Cozens, Kevin M. Weeks, Piet Herdewijn, Philipp Holliger
Article
Multidisciplinary Sciences
Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Jiun-Bo Chen, Faruk Ramadani, Marie O. Y. Pang, Rebecca L. Beavil, Mary D. Holdom, Alkistis N. Mitropoulou, Andrew J. Beavil, Hannah J. Gould, Tse Wen Chang, Brian J. Sutton, James M. McDonnell, Anna M. Davies
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Line Ohm-Laursen, Hailong Meng, Jessica Chen, Julian Q. Zhou, Chris J. Corrigan, Hannah J. Gould, Steven H. Kleinstein
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Gintare Bucaite, Tara Kang-Pettinger, Jorge Moreira, Hannah J. Gould, Louisa K. James, Brian J. Sutton, James M. McDonnell
JOURNAL OF IMMUNOLOGY
(2019)
Review
Allergy
D. Ferastraoaru, H. J. Bax, C. Bergmann, M. Capron, M. Castells, D. Dombrowicz, E. Fiebiger, H. J. Gould, K. Hartmann, U. Jappe, G. Jordakieva, D. H. Josephs, F. Levi-Schaffer, V Mahler, A. Poli, D. Rosenstreich, F. Roth-Walter, M. Shamji, E. H. Steveling-Klein, M. C. Turner, E. Untersmayr, S. N. Karagiannis, E. Jensen-Jarolim
CLINICAL AND TRANSLATIONAL ALLERGY
(2020)