Article
Biochemistry & Molecular Biology
Hanna Mannell, Petra Kameritsch, Heike Beck, Alexander Pfeifer, Ulrich Pohl, Kristin Pogoda
Summary: The gap junction protein Cx43 is involved in endothelial cell migration and angiogenesis through its interaction with the phosphatase SHP-2, enhancing its activity and regulating migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Takenori Kotani, Noriko Ihara, Saki Okamoto, Jajar Setiawan, Tasuku Konno, Yasuyuki Saito, Yoji Murata, Takashi Matozaki
Summary: Cross talk between different signaling pathways is important for the regulation of intestinal homeostasis and tumorigenesis. Expression of active K-Ras in intestinal epithelial cells promotes proliferation and generation of goblet cells, while counter-regulating Wnt signaling for proper regulation of intestinal epithelial cell homeostasis.
Article
Endocrinology & Metabolism
Adrienn Markovics, Sydney Lupo, Niyati Patel, Katalin Mikecz, D. Rick Sumner, Ryan D. Ross
Summary: This study found that Shp1 overexpression leads to increased bone mass and improved mechanical properties in mice, but only in 28-day-old mice. Female SHP1-Tg mice showed higher trabecular bone volume, trabecular number, and connectivity density compared to wildtype mice.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Immunology
QinLei Gu, Kenneth S. Tung, Ulrike M. Lorenz
Summary: To achieve a healthy and functional immune system, there is a delicate balance between the activation of Tcon cells and the suppression by Treg cells. SHP-1 plays a role in modulating this balance by regulating Tcon cell resistance to Treg-mediated suppression. However, the role of SHP-1 in Treg function is still not fully understood.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chakrabhavi Dhananjaya Mohan, Chulwon Kim, Kodappully Sivaraman Siveen, Kanjoormana Aryan Manu, Shobith Rangappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Alan Prem Kumar, Kwang Seok Ahn
Summary: Crocetin inhibits STAT3 activation in HCC cells and affects the expression of multiple genes associated with cancer, thereby suppressing cell proliferation and invasive capacity.
Article
Biochemistry & Molecular Biology
Jung-Ha Park, In Kyo Jung, Yongjun Lee, Soojung Jin, Hee Jung Yun, Byung Woo Kim, Hyun Ju Kwon
Summary: Drinking alcohol can stimulate the proliferation of small intestinal epithelial cells, potentially through activating the Wnt signaling pathway. This study's findings demonstrate the effects of alcohol consumption on small intestinal epithelial cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Yi-Yong Wang, Bin Gao, Yong Yang, Shao-Bin Jia, Xue-Ping Ma, Ming-Hao Zhang, Li-Juan Wang, Ai-Qun Ma, Qin-Ning Zhang
Summary: This study aimed to explore the regulatory mechanism of histone deacetylase 3 (HDAC3) and DNA methyltransferase 1 (DNMT1)/Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1) axis in heart failure (HF). The study found that HDAC3 modified DNMT1 through deacetylation to suppress SHP-1 expression, which in turn led to the development of cardiomyocyte hypertrophy-induced HF. This provides potential therapeutic targets for HF treatment.
Article
Biochemistry & Molecular Biology
Rukang Zhang, Dong Chen, Hao Fan, Rong Wu, Jiayi Tu, Freya Q. Zhang, Mei Wang, Hong Zheng, Cheng-Kui Qu, Shannon E. Elf, Brandon Faubert, Yu-Ying He, Marc B. Bissonnette, Xue Gao, Ralph J. DeBerardinis, Jing Chen
Summary: Environmental stresses induce reductive carboxylation in cancer cells, which is involved in maintaining redox homeostasis and lipid biosynthesis. Different cellular signals induce reductive carboxylation by regulating the tyrosine phosphorylation and activation of IDH1, achieved through inhibition of the protein phosphatase SHP-2.
CELL CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luis Cedeno-Rosario, David Honda, Autumn M. Sunderland, Mark D. Lewandowski, William R. Taylor, Deborah N. Chadee
Summary: MLK3 plays a crucial role in the cell cycle of ovarian cancer cells, with its activity being regulated by phosphorylation by CDK1 and CDK2, affecting the activities of both MLK3 and c-Jun N-terminal kinase in G1/S, G2, and M phases.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Jiupeng Zhou, Hui Guo, Yongfeng Zhang, Heng Liu, Quanli Dou
Summary: This study conducted a meta-analysis to assess the prognostic value of SHP2 in tumor patients. The results showed that the expression of SHP2 was not significantly correlated with clinical stages, DFS, and OS in most solid tumors. However, the prognostic effect varied greatly with tumor sites, with SHP2 expression being positively related to early clinical stage in hepatocellular carcinoma and associated with shorter OS in pancreatic carcinoma and laryngeal carcinoma.
Article
Cell Biology
Emily C. Suter, Eva M. Schmid, Andrew R. Harris, Erik Voets, Brian Francica, Daniel A. Fletcher
Summary: The study reveals that the phagocytic decisions of macrophages are regulated by the ratio of activating ligand to inhibitory ligand, and a ratio of at least 10:1 is required for promoting phagocytosis. Ratiometric signaling is crucial for phagocytosis of tumor cells and can be modified by blocking SIRP alpha.
Article
Biochemistry & Molecular Biology
Laurent Schmied, Thuy T. Luu, Jonas N. Sondergaard, Sophia H. Hald, Stephan Meinke, Dara K. Mohammad, Sunitha B. Singh, Corinna Mayer, Giovanna Perinetti Casoni, Michael Chrobok, Heinrich Schlums, Giorgia Rota, Hieu M. Truong, Lisa S. Westerberg, Greta Guarda, Evren Alici, Arnika K. Wagner, Nadir Kadri, Yenan T. Bryceson, Mezida B. Saeed, Petter Hoglund
Summary: Natural killer (NK) cells recognize infected cells and tumors. The function of NK cells depends on balanced signaling from activating and inhibitory receptors. The subcellular localization of tyrosine phosphatase SHP-1 determines NK cell tolerance and education. Education of NK cells leads to reduced synapse accumulation of SHP-1 and augmented signaling from activating receptors.
Article
Immunology
Gabriela Andrejeva, Benjamin J. Capoccia, Ronald R. Hiebsch, Michael J. Donio, Isra M. Darwech, Robyn J. Puro, Daniel S. Pereira
Summary: The SIRP alpha/CD47 axis is a crucial innate immune checkpoint allowing cancer cells to evade macrophage phagocytosis. The novel anti-SIRP antibodies, SIRP-1 and SIRP-2, show promising single-agent and combined phagocytosis effects on tumor cells and are safe to T cell functionality.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Siti Norbaini Sabtu, S. F. Abdul Sani, L. M. Looi, S. F. Chiew, Dharini Pathmanathan, D. A. Bradley, Z. Osman
Summary: The study used Raman spectroscopy to analyze metabolic changes in EMT breast cancer tissue and found significant differences between EMT and non-EMT breast cancer, providing insights into biochemical alterations in cancer progression.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Federica Bono, Zaira Tomasoni, Veronica Mutti, Giulia Sbrini, Rajesh Kumar, Francesca Longhena, Chiara Fiorentini, Cristina Missale
Summary: The heteromer composed of dopamine D1 and D3 receptors can activate Erk1/2 and Akt signaling in a G protein-independent, beta-arrestin 1-dependent way. Abnormal levels of D1R-D3R heteromer in Parkinson's disease patients with L-DOPA-induced dyskinesia (LID) suggest its involvement in the abnormal PKA-Shp-2-Erk1/2 pathway. The signaling pathway induced by the D1R/D3R heteromer involves D1R molecular effectors, Gs protein, PKA, phosphatase Shp-2, and beta-arrestins.