Role of Leucine-Rich Repeat Proteins in the Development and Function of Neural Circuits

LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11

(2012) Koji Sagane et al.   International Journal of Biological Sciences

Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry

(2012) Inês Sousa et al.   Molecular Autism

The Drosophila Toll Signaling Pathway

(2011) S. Valanne et al.   JOURNAL OF IMMUNOLOGY

Postsynaptic TrkC and Presynaptic PTPσ Function as a Bidirectional Excitatory Synaptic Organizing Complex

(2011) Hideto Takahashi et al.   NEURON

Distinct Protein Domains and Expression Patterns Confer Divergent Axon Guidance Functions for Drosophila Robo Receptors

(2010) Bettina Spitzweck et al.   CELL

Functional Diversity of Robo Receptor Immunoglobulin Domains Promotes Distinct Axon Guidance Decisions

(2010) Timothy A. Evans et al.   CURRENT BIOLOGY

Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity

(2010) M. Inaki et al.   DEVELOPMENT

Moving away from the midline: new developments for Slit and Robo

(2010) A. R. Ypsilanti et al.   DEVELOPMENT

Trans-synaptic Adhesions between Netrin-G Ligand-3 (NGL-3) and Receptor Tyrosine Phosphatases LAR, Protein-tyrosine Phosphatase δ (PTPδ), and PTPσ via Specific Domains Regulate Excitatory Synapse Formation

(2010) Seok-Kyu Kwon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligodendrocyte-Myelin Glycoprotein and Nogo Negatively Regulate Activity-Dependent Synaptic Plasticity

(2010) S. J. Raiker et al.   JOURNAL OF NEUROSCIENCE

Selected SALM (Synaptic Adhesion-Like Molecule) Family Proteins Regulate Synapse Formation

(2010) W. Mah et al.   JOURNAL OF NEUROSCIENCE

Nogo-A Stabilizes the Architecture of Hippocampal Neurons

(2010) M. Zagrebelsky et al.   JOURNAL OF NEUROSCIENCE

ADAM22, A Kv1 Channel-Interacting Protein, Recruits Membrane-Associated Guanylate Kinases to Juxtaparanodes of Myelinated Axons

(2010) Y. Ogawa et al.   JOURNAL OF NEUROSCIENCE

Adam22 Is a Major Neuronal Receptor for Lgi4-Mediated Schwann Cell Signaling

(2010) E. Ozkaynak et al.   JOURNAL OF NEUROSCIENCE

LRRTMs and Neuroligins Bind Neurexins with a Differential Code to Cooperate in Glutamate Synapse Development

(2010) T. J. Siddiqui et al.   JOURNAL OF NEUROSCIENCE

Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia

(2010) A Piton et al.   MOLECULAR PSYCHIATRY

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice

(2010) Sergey V Shmelkov et al.   NATURE MEDICINE

An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates

(2010) Ting Guo et al.   NATURE NEUROSCIENCE

Functions of Nogo proteins and their receptors in the nervous system

(2010) Martin E. Schwab   NATURE REVIEWS NEUROSCIENCE

Branching out: mechanisms of dendritic arborization

(2010) Yuh-Nung Jan et al.   NATURE REVIEWS NEUROSCIENCE

Neural Map Formation in the Mouse Olfactory System

(2010) Hitoshi Sakano   NEURON

Design Principles of Insect and Vertebrate Visual Systems

(2010) Joshua R. Sanes et al.   NEURON

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy

(2010) Yuko Fukata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Oligodendrocyte Differentiation and Myelination

(2010) B. Emery   SCIENCE

Mechanisms and Molecules of Neuronal Wiring: A Primer

(2010) A. L. Kolodkin et al.   Cold Spring Harbor Perspectives in Biology

Target recognition at the tips of postsynaptic filopodia: accumulation and function of Capricious

(2009) H. Kohsaka et al.   DEVELOPMENT

Differential expression of slitrk family members in the mouse nervous system

(2009) François Beaubien et al.   DEVELOPMENTAL DYNAMICS

LGI1mutations in autosomal dominant and sporadic lateral temporal epilepsy

(2009) Carlo Nobile et al.   HUMAN MUTATION

Converging Evidence for the Nogo-66 Receptor Gene in Schizophrenia

(2009) A. N. Voineskos   JOURNAL OF NEUROSCIENCE

The genetics of Tourette syndrome: A review

(2009) Julia A. O'Rourke et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology

(2009) Katherine Owuor et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Supporting evidence for LRRTM1 imprinting effects in schizophrenia

(2009) K U Ludwig et al.   MOLECULAR PSYCHIATRY

Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy

(2009) Yu-Dong Zhou et al.   NATURE MEDICINE

Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses

(2009) Jooyeon Woo et al.   NATURE NEUROSCIENCE

Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map

(2009) Weizhe Hong et al.   NATURE NEUROSCIENCE

Synaptogenic Proteins and Synaptic Organizers: “Many Hands Make Light Work”

(2009) Nils Brose   NEURON

An Unbiased Expression Screen for Synaptogenic Proteins Identifies the LRRTM Protein Family as Synaptic Organizers

(2009) Michael W. Linhoff et al.   NEURON

LIG Family Receptor Tyrosine Kinase-Associated Proteins Modulate Growth Factor Signals during Neural Development

(2009) Kenji Mandai et al.   NEURON

LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation

(2009) Joris de Wit et al.   NEURON

LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation

(2009) Jaewon Ko et al.   NEURON

Neurexin 1 (NRXN1) Deletions in Schizophrenia

(2009) G. Kirov et al.   SCHIZOPHRENIA BULLETIN

Dendritic Targeting in the Leg Neuropil of Drosophila: The Role of Midline Signalling Molecules in Generating a Myotopic Map

(2009) David J. Brierley et al.   PLOS BIOLOGY

Midline Signalling Systems Direct the Formation of a Neural Map by Dendritic Targeting in the Drosophila Motor System

(2009) Alex Mauss et al.   PLOS BIOLOGY

Molecular Mechanisms of Presynaptic Differentiation

(2008) Yishi Jin et al.   Annual Review of Cell and Developmental Biology

A Novel Loss-of-Function LGI1 Mutation Linked to Autosomal Dominant Lateral Temporal Epilepsy

(2008) Pasquale Striano et al.   ARCHIVES OF NEUROLOGY

Structural insight into Slit–Robo signalling

(2008) Erhard Hohenester   BIOCHEMICAL SOCIETY TRANSACTIONS

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

CASK Functions as a Mg2+-Independent Neurexin Kinase

(2008) Konark Mukherjee et al.   CELL

The leucine-rich repeat structure

(2008) J. Bella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila

(2008) Svetla Dimitrova et al.   DEVELOPMENTAL BIOLOGY

Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo

(2008) Shunsaku Homma et al.   GENE EXPRESSION PATTERNS

The SALM Family of Adhesion-like Molecules Forms Heteromeric and Homomeric Complexes

(2008) Gail K. Seabold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Function for the Nogo-66 Receptor NgR1: Regulation of Dendritic Spine Morphology and Activity-Dependent Synaptic Strength

(2008) H. Lee et al.   JOURNAL OF NEUROSCIENCE

Genetic Variants of Nogo-66 Receptor with Possible Association to Schizophrenia Block Myelin Inhibition of Axon Growth

(2008) S. Budel et al.   JOURNAL OF NEUROSCIENCE

Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities

(2008) K Katayama et al.   MOLECULAR PSYCHIATRY

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE

Serum Response Factor Mediates NGF-Dependent Target Innervation by Embryonic DRG Sensory Neurons

(2008) S. Rasika Wickramasinghe et al.   NEURON

Alternative Splicing of the Robo3 Axon Guidance Receptor Governs the Midline Switch from Attraction to Repulsion

(2008) Zhe Chen et al.   NEURON

A Screen of Cell-Surface Molecules Identifies Leucine-Rich Repeat Proteins as Key Mediators of Synaptic Target Selection

(2008) Mitsuhiko Kurusu et al.   NEURON

Characterization of sensory deficits in TrkB knockout mice

(2008) P. Perez-Pinera et al.   NEUROSCIENCE LETTERS

Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation

(2008) Bangfu Zhu et al.   PLOS BIOLOGY

Netrin-G2 and netrin-G2 ligand are both required for normal auditory responsiveness

(2007) W. Zhang et al.   GENES BRAIN AND BEHAVIOR