Article
Biochemistry & Molecular Biology
Qingsong Tang, Wenxue Li, Zhongxiang Ren, Qi Ding, Xie Peng, Zhiru Tang, Jiaman Pang, Yetong Xu, Zhihong Sun
Summary: This study evaluated the effects of a low-protein diet supplemented with sodium butyrate, medium-chain fatty acids, and n-3 polyunsaturated fatty acids on nutrient utilization and lipid and amino acid metabolism in weaned pigs. The results showed that the supplementation of medium-chain fatty acids improved the digestibility of dry matter and total phosphorus in pigs. The metabolites related to sugar metabolism and oxidative phosphorylation in the liver significantly changed with the low-protein diet. The supplementation of sodium butyrate, medium-chain fatty acids, and n-3 polyunsaturated fatty acids altered the metabolites associated with sugar metabolism, pyrimidine metabolism, lipid metabolism, and amino acid metabolism in the liver of pigs. Furthermore, the supplementation of n-3 polyunsaturated fatty acids increased the concentration of glutamate dehydrogenase and the mRNA abundances of sterol regulatory element-binding protein 1, acetyl-CoA carboxylase, and fatty acid synthase in the liver. Overall, the low-protein diet supplemented with medium-chain fatty acids improved nutrient digestibility, and the supplementation of medium-chain fatty acids and n-3 polyunsaturated fatty acids promoted lipid and amino acid metabolisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Lu-Min Gao, Tian-Tian Zhou, Zhong-Pin Chen, Teketay Wassie, Biao Li, Xin Wu, Yu-Long Yin
Summary: Maternal dietary supplementation with yeast-based nucleotide (YN) during late pregnancy improves reproductive performance of sows by regulating placental nutrient transport and affecting liver metabolism in neonatal piglets, leading to decreased stillbirth rate and intra-uterine growth restriction rate, as well as alterations in serum and liver profiles.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Environmental Sciences
Ankita Singla, Jaspal Singh Hundal, Amlan Kumar Patra, Manju Wadhwa, Veena Nagarajappa, Puneet Malhotra
Summary: Supplementation of Emblica officinalis fruit pomace at 20 g/kg dry matter intake improves milk yield and production efficiency in buffaloes, while decreasing methane production and intensity. This can potentially lead to more sustainable and environmentally friendly buffalo production practices.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Leriana Garcia Reis, Thiago Henrique Silva, Gisele Mouro Ravagnani, Cristian Hernando Garcia Martinez, Marcia Saladini Vieira Salles, Andre Furugen Cesar Andrade, Nara Regina Brandao Consolo, Simone Maria Massami Kitamura Martins, Fernando de Oliveira Bussiman, Mauricio Xavier Silva Oliveira, Dante Pazzanese Duarte Lanna, Arlindo Saran Netto
Summary: It was found in the study that the supplementation of gilts with n-3 and n-6 enriched diets had significant effects on serum composition, fatty acid levels, and offspring weight compared to the control group. Offspring from gilts supplemented with n-3 had higher body weight, increased daily weight gain, and higher serum EPA levels. These results demonstrate the beneficial effects of PUFA-enriched cow's milk supplementation for the offspring of gilts.
Article
Agricultural Engineering
Karol Dudek, German Buitron, Idania Valdez-Vazquez
Summary: This study demonstrated the successful solubilization of Agave bagasse fibers using acidogenesis process with native microbiota, resulting in increased VFA production, sCOD, and VFA yield. Nutrient supplementation promoted alkaline pH, leading to different VFA compositions and yields.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Chang Cui, Caichi Wu, Jun Wang, Xiaoyu Zheng, Ziwei Ma, Pengwei Zhu, Wutai Guan, Shihai Zhang, Fang Chen
Summary: In this study, we found that supplementing sow diets with leucine during late gestation can alter placental metabolism and promote the transport of nutrients (amino acids, glucose, and fatty acids) between mother and fetus.
Article
Biochemistry & Molecular Biology
Brandon Pike, Jinan Zhao, Julie A. Hicks, Feng Wang, Rachel Hagen, Hsiao-Ching Liu, Jack Odle, Xi Lin
Summary: This study investigated the effects of peroxisome proliferator-activated receptor alpha (PPARα) on carnitine status and intestinal fatty acid oxidation in neonates. Suckled newborn piglets were fed different diets with or without clofibrate, succinate+glycerol, tri-valerate, tri-hexanoate, or tri-2-methylpentanoate. Clofibrate increased carnitine concentrations in the liver and plasma, but had no effect in the intestine. TC5 and TMPA stimulated fatty acid oxidation, while TC6 had no effect. These results suggest that clofibrate improves carnitine status and increases fatty acid oxidation in neonates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Luis Cal-Pereyra, Jose Ramiro Gonzalez-Montana, Karina Neimaur Fernandez, Mayra Cecilia Abreu-Palermo, Maria Jose Martin Alonso, Valente Velazquez-Ordonez, Jorge Acosta-Dibarrat
Summary: The aim of this study was to investigate the influence of different sources of polyunsaturated fatty acids (PUFA) in the diet of ewes on the fatty acid profile in lamb muscles, in order to provide healthier meat for consumers. Results showed that the diet of ewes during lactation significantly impacted the lipid profile in lamb muscles, increasing the concentrations of n-3 and n-6 PUFA, ALA, LA, AA, DHA, and EPA. The supplementation of ewes with fish oil and/or a PUFA-rich diet positively influenced the LA/ALA ratio in lamb meat.
Article
Cardiac & Cardiovascular Systems
Richard L. Weinberg, Robert D. Brook, Melvyn Rubenfire, Kim A. Eagle
Summary: Omega-3 polyunsaturated fatty acids play a key role in heart-healthy diet, and can be obtained through fatty fish consumption or fish oil supplementation. They not only treat hypertriglyceridemia, but also prevent cardiovascular events, with additional benefits such as reducing inflammation and improving plaque stability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Yang Zhang, Zhi Cao, Laidi Wang, Bingqiang Dong, Shangzong Qi, Xinlei Xu, Qiang Bao, Yu Zhang, Qi Xu, Guobin Chang, Guohong Chen
Summary: This study evaluated the effects of feeding time of a linseed oil diet on duck meat performance and gene expression. The results showed that linseed oil had no negative effect on duck performance or meat quality performance, but affected the composition of muscle fatty acids. Four weeks of feeding time may be a key factor in promoting the deposition of n-3 polyunsaturated fatty acids in duck meat.
Article
Agriculture, Dairy & Animal Science
Ali Asghar Ahmadi-Sefat, Kamran Taherpour, Hossein Ali Ghasemi, Mohammad Akbari Gharaei, Hassan Shirzadi, Farhad Rostami
Summary: The study demonstrates that the supplementation of emulsifier blend can have positive effects on broiler performance, digestibility, and gut morphology. Particularly, the inclusion of 2 g/kg of emulsifier blend in low nutrient diets shows the best results.
Article
Agriculture, Dairy & Animal Science
Qi Qi, Chengjun Hu, Haojie Zhang, Ruiping Sun, Quanwei Liu, Kun Ouyang, Yali Xie, Xiang Li, Wei Wu, Yuhang Liu, Guiping Zhao, Limin Wei
Summary: This study found that adding 0.05% putrescine can increase the average daily gain of broilers and increase the content of essential amino acids while reducing saturated fatty acids in muscle, thus improving meat quality.
Article
Agriculture, Dairy & Animal Science
Z. Yang, E. Asare, Y. Yang, J. J. Yang, H. M. Yang, Z. Y. Wang
Summary: Supplementation of betaine in the diet improved zootechnical performance, decreased abdominal fat and sebum thickness in geese at 63 days of age, and reduced triglyceride and total cholesterol content in serum. Betaine also increased hormone sensitive lipase activity while decreasing fatty acid synthase activity in geese, leading to reduced lipid droplet area. Further research is needed to fully understand the mechanisms behind these effects.
Article
Agriculture, Dairy & Animal Science
Chaiwat Arjin, Chanmany Souphannavong, Rakkiat Norkeaw, Niraporn Chaiwang, Supamit Mekchay, Apinya Sartsook, Maninphan Thongkham, Thanchanok Yosen, Warintorn Ruksiriwanich, Sarana Rose Sommano, Korawan Sringarm
Summary: The supplementation of perilla cake improved pig performance, increased PUFA fatty acids, and decreased the proportion of saturated and unsaturated fatty acids in pork, while not affecting carcass traits and meat quality. This alternative source of raw material can be considered for functional feed additives in livestock production.
Article
Nutrition & Dietetics
Jean-Baptiste Bizeau, Mayssa Albouery, Stephane Gregoire, Benedicte Buteau, Lucy Martine, Marine Crepin, Alain M. Bron, Olivier Berdeaux, Niyazi Acar, Benoit Chassaing, Marie-Agnes Bringer
Summary: This study investigated the impact of dietary intake of inulin on the levels of plasmalogens in the mouse cortex. The results showed that inulin supplementation reduced the abundance of ethanolamine plasmalogens in the cortex, but had no effect on enzyme gene expression or fatty acid profile.
Article
Neurosciences
Fiona Hollis, Ellen Siobhan Mitchell, Carles Canto, Dongmei Wang, Carmen Sandi
Article
Psychology, Biological
Nina S. Stachenfeld, Cheryl A. Leone, E. Soibhan Mitchell, Eric Freese, Laura Harkness
PHYSIOLOGY & BEHAVIOR
(2018)
Article
Nutrition & Dietetics
Julien Benjamin Pujol, Nicolas Christinat, Yann Ratinaud, Claudia Savoia, Siobhan E. Mitchell, El Hadji M. Dioum
Review
Clinical Neurology
Julius Schuster, Ellen S. Mitchell
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Article
Nutrition & Dietetics
Ellen S. Mitchell, Kathy Musa-Veloso, Shafagh Fallah, Han Youl Lee, Peter J. De Chavez, Sigrid Gibson
Article
Environmental Sciences
Ellen S. Mitchell, Qiuchen Yang, Heather Behr, Annabell Ho, Laura DeLuca, Christine N. May, Andreas Michaelides
Summary: This study examined the impact of psychosocial characteristics on weight loss outcomes in a self-managed digital program. The findings suggest that anxiety plays a key role in weight loss, while flourishing can predict the weight loss outcome group. The study highlights the importance of considering psychosocial factors in creating effective interventions, particularly in underexplored digital weight loss programs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Ellen S. Mitchell, Qiuchen Yang, Annabell S. Ho, Heather Behr, Christine N. May, Laura DeLuca, Andreas Michaelides
Summary: The study found that consuming more low-energy-dense and less high-energy-dense foods, as well as improving nutrition knowledge and making healthier food choices, were associated with weight loss in a digital commercial weight loss program. The inclination towards food choice even when just depicted was also linked to long-term weight loss.
Article
Nutrition & Dietetics
Christine N. May, Annabell Suh Ho, Qiuchen Yang, Meaghan McCallum, Neil M. Iyengar, Amy Comander, Ellen Siobhan Mitchell, Andreas Michaelides
Summary: This retrospective study explores the effectiveness of a digital commercial weight loss program (Noom) in cancer survivors and matched controls, showing that survivors lost less weight than controls but still achieved significant weight loss in four months. Cancer survivors may require additional support to engage in weight management behaviors.
Article
Environmental Sciences
Heather Behr, Annabell Suh Ho, Ellen Siobhan Mitchell, Qiuchen Yang, Laura DeLuca, Andreas Michealides
Summary: Emotion words during goal pursuit in a weight loss program were analyzed using a computational text analysis approach. Positive emotion words remained stable while negative emotion words increased over time, contrary to self-report findings. Concrete goal setters used more positive words and there was a trend towards greater weight loss with higher negative emotion word use.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Meaghan McCallum, Annabell Suh Ho, Christine N. May, Heather Behr, Ellen Siobhan Mitchell, Andreas Michealides
Summary: The study found that participation in a commercial behavior change weight management program can lead to improvements in body positivity and self-compassion, with greater engagement associated with these improvements. The results also suggest that curriculum and coaching can help individuals experience enhancements in body positivity and self-compassion while learning about acceptance and commitment therapy, dialectical behavior therapy, and cognitive behavioral therapy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Andreas Michaelides, Ellen Siobhan Mitchell, Heather Behr, Annabell Suh Ho, Grant Hanada, Jihye Lee, Sue McPartland
Summary: This pilot study examined the effects of a cognitive behavioral therapy-based generalized weight management intervention on executive functioning and brain activity. The results showed that the intervention group had improved accuracy and neural markers of executive function compared to the control group, and also had greater weight loss.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Heather Behr, Sydney Earl, Annabell Suh Ho, Jihye Lee, Ellen Siobhan Mitchell, Meaghan McCallum, Christine N. May, Andreas Michaelides
Summary: Health-promoting lifestyle behaviors are associated with disease mortality reduction and improved well-being. This study examined the changes in health-promoting behaviors and their associations with weight loss, retention, and engagement in a digital weight-management program. Participants lost a significant amount of weight and reported improved health-promoting behaviors. Learned health-promoting behaviors were better predictors of retention and program engagement. The findings highlight the potential benefits of digital weight management interventions.
Article
Health Care Sciences & Services
Ellen Siobhan Mitchell, Alexander Fabry, Annabell Suh Ho, Christine N. May, Matthew Baldwin, Paige Blanco, Kyle Smith, Andreas Michaelides, Mostafa Shokoohi, Michael West, Kim Gotera, Omnya El Massad, Anna Zhou
Summary: This study analyzed the impact of Noom Weight use on health care resource utilization (HRU) and health care costs, comparing 43,047 program users with 14,555 non-users. The results showed that Noom Weight users had lower costs and resource utilization compared to non-users. The study suggests that Noom Weight could be a cost-effective weight management program for individuals with overweight and obesity.
JMIR MHEALTH AND UHEALTH
(2023)
Article
Health Care Sciences & Services
Meaghan McCallum, Annabell Suh Ho, Ellen Siobhan Mitchell, Christine N. May, Heather Behr, Lorie Ritschel, Kirk Mochrie, Andreas Michaelides
Summary: This study evaluated the feasibility, acceptability, and preliminary outcomes of Noom Mood, a commercial mobile cognitive behavioral therapy- and mindfulness-based program. Results showed that the majority of participants found the program easy to use, felt confident recommending it to others, and perceived it to be effective in improving stress and anxiety. Significant improvements were observed in anxiety symptoms, perceived stress, depressive feelings, emotion regulation, and optimism. Participants reported benefiting most from learning skills, interacting with program features, and gaining awareness of their emotions and thought patterns. Suggestions were also made to improve product functionality and usability.
JMIR FORMATIVE RESEARCH
(2022)
Article
Cell Biology
David Vauzour, Maria Camprubi-Robles, Sophie Miquel-Kergoat, Cristina Andres-Lacueva, Diana Banati, Pascale Barberger-Gateau, Gene L. Bowman, Laura Caberlotto, Robert Clarke, Eef Hogervorst, Amanda J. Kiliaan, Ugo Lucca, Claudine Manach, Anne-Marie Minihane, Ellen Siobhan Mitchell, Robert Perneczky, Hugh Perry, Anne-Marie Roussel, Jeroen Schuermans, John Sijben, Jeremy P. E. Spencer, Sandrine Thuret, Ondine van de Rest, Maurits Vandewoude, Keith Wesnes, Robert J. Williams, Robin S. B. Williams, Maria Ramirez
AGEING RESEARCH REVIEWS
(2017)
