Article
Marine & Freshwater Biology
Tianyu Wang, Shanshan Wu, Jianjie Chen, Lijuan Li, Jinling Cao
Summary: This study investigated the alleviating effects of sesamin on thyroid endocrine disruption caused by fluoride in zebrafish. Sesamin significantly improved growth performance and reduced mortality rate in adults, while also improving hatching rate and body length and alleviating spinal curvature and cyst formation in embryos and larvae. It also alleviated damage to thyroid tissues, reduced oxidative stress, improved thyroid hormone imbalance, and reversed the expression of endocrine-related genes.
AQUATIC TOXICOLOGY
(2023)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Toxicology
Sayed Aliul Hasan Abdi, Abuzer Ali, Shabihul Fatma Sayed, Amena Ali, Shaivad Shabee Hulhasan Abadi, Abu Tahir, Mohd Amir Afjal, Hina Rashid, Omar M. Aly, Sumathi Nagarajan
Summary: Widespread and irrational or long-term use of paracetamol may be harmful to human endocrine homeostasis, especially during pregnancy. Interactions with reproductive hormone receptors can disrupt stability and synthesis of reproductive hormones.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Review
Biochemistry & Molecular Biology
Christina Stern, Sarah Schwarz, Gerit Moser, Silvija Cvitic, Evelyn Jantscher-Krenn, Martin Gauster, Ursula Hiden
Summary: During pregnancy, the placenta plays a crucial role in regulating maternal physiology by secreting a variety of hormones and proteins. Maternal insulin resistance increases to supply glucose for the developing fetus, with a compensation in beta-cell mass and function. Sex differences may influence placenta-derived hormones and proteins, impacting the regulation of maternal glucose metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Neena Roy, Elisa Mascolo, Clara Lazzaretti, Elia Paradiso, Sara D'Alessandro, Kornelia Zareba, Manuela Simoni, Livio Casarini
Summary: The accumulation of endocrine-disrupting pollutants in the environment poses an increasing exposure risk to humans, potentially impacting reproductive functions, particularly female fertility. Studies suggest that these chemicals may interfere with follicle-stimulating hormone-mediated signaling pathways, ultimately affecting the female reproductive system.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Wang Lin, Huimin Luo, Jingyi Wu, Xiangli Liu, Beibei Cao, Yuqing Liu, Pinhong Yang, Jifeng Yang
Summary: The coexistence of eutrophication and plastic pollution in the aquatic environment is a global water pollution problem. The presence of polystyrene microplastics (PSMPs) increases the accumulation of microcystin-LR (MC-LR) in zebrafish gonads, exacerbating reproductive damage and endocrine disruption. These results show that PSMPs can serve as carriers to increase the bioaccumulation of MC-LR and aggravate reproductive damage and endocrine disruption.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Food Science & Technology
Yue Leng, Li Ren, Shu Niu, Tiehua Zhang, Jie Zhang
Summary: The metabolites of plasticizers did not show direct effects on the glucocorticoid receptor, but they could synergistically activate the receptor in combination with dexamethasone. The study found that monobutyl phthalate (MBP) in combination with dexamethasone enhanced the expression of specific genes and proteins regulated by the glucocorticoid receptor. The interactions between MBP and the glucocorticoid receptor were influenced by the chemical properties of MBP, with hydrophobic and hydrogen bonding interactions playing crucial roles in stabilizing the complex.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Elisabet Perez-Albaladejo, Raquel Pinteno, Maria del Carmen Aznar-Luque, Marta Casado, Cristina Postigo, Cinta Porte
Summary: This study explored the toxicity potential of several haloacetic acids (HAAs) in water, with a focus on their effects on human cells. The results showed that iodoacetic acid (IAA) had the highest cytotoxicity and ability to generate reactive oxygen species (ROS). These substances also caused damage to the endocrine system and genotoxicity. The findings suggest that low concentrations of these substances may have teratogenic and endocrine disruption effects on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Endocrinology & Metabolism
Laetitia L. Lecante, Sabrina Leverrier-Penna, Thomas Gicquel, Frank Giton, Nathalie Costet, Christele Desdoits-Lethimonier, Laurianne Lesne, Bernard Fromenty, Vincent Lavoue, Antoine D. Rolland, Severine Mazaud-Guittot
Summary: The study found that APAP can impact the development of fetal human ovaries, especially during the 10-12 week window of heightened sensitivity. APAP reduced the total cell number in ovaries, induced cell death, and decreased KI67-positive cell density independently of fetal age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Environmental Sciences
Jiefeng Liang, Qian S. Liu, Zhihua Ren, Ke Min, Xiaoxi Yang, Fang Hao, Qing Zhang, Qian Liu, Qunfang Zhou, Guibin Jiang
Summary: This study systematically investigated the potential endocrine disrupting activities of four common parabens. The results showed that parabens exhibited typical estrogenic effects and could disrupt the endocrine system by activating estrogen receptors and disturbing steroid hormone synthesis and secretion, posing potential risks to the environment and human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell & Tissue Engineering
Ankita Kaushik, S. M. Metkari, Subhan Ali, Deepa Bhartiya
Summary: The reproductive health of men is declining due to increased exposure to endocrine-disrupting chemicals (EDCs). A study was conducted to investigate the effects of neonatal exposure to EDCs on testicular health and explore potential strategies for reversing these effects. The study found that oral administration of a nano-formulation of resveratrol or inter-tubular transplantation of mesenchymal stromal cells (MSCs) effectively improved spermatogenesis, restored the epigenetic status of stem cells, and reduced the incidence of testicular tumors. These findings provide a basis for further clinical studies in this area.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Environmental Sciences
Margarida Lorigo, Elisa Cairrao
Summary: This study investigated the effects of the UV-B filter octylmethoxycinnamate (OMC) on rat aorta vasculature and found that OMC can relax the rat aorta through multiple mechanisms, potentially causing hypotension by excessive NO release and blockade of L-Type voltage-operated Ca2+ channels.
Article
Pharmacology & Pharmacy
Tianyi Li, Paraskevi Vazakidou, Pim E. G. Leonards, Anastasios Damdimopoulos, Eleftheria Maria Panagiotou, Catarina Arnelo, Kerstin Jansson, Karin Pettersson, Kiriaki Papaikonomou, Majorie van Duursen, Pauliina Damdimopoulou
Summary: This study aims to identify the mechanisms of endocrine disruption using two EDCs, DES and KTZ. The results show that both chemicals affect the pathways related to folliculogenesis and steroidogenesis. Stearoyl-CoA desaturase (SCD) may serve as a potential biomarker of EDC exposure and effects on ovaries.
Article
Environmental Sciences
Danielle R. Stevens, Emma M. Rosen, Kimi Van Wickle, Erin E. McNell, Paige A. Bommarito, Antonia M. Calafat, Julianne C. Botelho, Elena Sinkovskaya, Ann Przybylska, George Saade, Alfred Abuhamad, Kelly K. Ferguson
Summary: In early pregnancy, exposure to phthalates and replacement chemicals may have adverse effects on fetal growth. Phthalate biomarkers in urine were found to be associated with reduced fetal growth, while replacement biomarkers showed no such association.
ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Saganuwan Alhaji Saganuwan
Summary: This study investigated the effects of piroxicam on perchloric acid-induced disruption of thyroid hormones. The results showed that piroxicam can mitigate the interference of perchloric acid on thyroid hormones, as well as modulate liver enzymes, the immune system, and renal function.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemical Research Methods
Thomas A. Darde, Pierre Gaudriault, Remi Beranger, Clement Lancien, Annaelle Caillarec-Joly, Olivier Sallou, Nathalie Bonvallot, Cecile Chevrier, Severine Mazaud-Guittot, Bernard Jegou, Olivier Collin, Emmanuelle Becker, Antoine D. Rolland, Frederic Chalmel
Article
Obstetrics & Gynecology
S. Leverrier-Penna, R. T. Mitchell, E. Becker, L. Lecante, M. Ben Maamar, N. Homer, V. Lavoue, D. M. Kristensen, N. Dejucq-Rainsford, B. Jegou, S. Mazaud-Guittot
HUMAN REPRODUCTION
(2018)
Article
Virology
Laurent Houzet, Marcos Perez-Losada, Giulia Matusali, Claire Deleage, Nathalie Dereuddre-Bosquet, Anne-Pascale Satie, Florence Aubry, Emmanuelle Becker, Bernard Jegou, Roger Le Grand, Brandon F. Keele, Keith A. Crandall, Nathalie Dejucq-Rainsford
JOURNAL OF VIROLOGY
(2018)
Article
Cell Biology
Estelle Lecluze, Bernard Jegou, Antoine D. Rolland, Frederic Chalmerl
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2018)
Article
Multidisciplinary Sciences
David Mobjerg Kristensen, Christele Desdoits-Lethimonier, Abigail L. Mackey, Marlene Danner Dalgaard, Federico De Masi, Cecilie Hurup Munkbol, Bjarne Styrishave, Jean-Philippe Antignac, Bruno Le Bizec, Christian Platel, Anders Hay-Schmidt, Tina Kold Jensen, Laurianne Lesne, Severine Mazaud-Guittot, Karsten Kristiansen, Soren Brunak, Michael Kjaer, Anders Juul, Bernard Jegou
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Aurore Gely-Pernot, Chunxiang Hao, Louis Legoff, Luc Multigner, Shereen Cynthia D'Cruz, Christine Kervarrec, Bernard Jegou, Sergei Tevosian, Fatima Smagulova
SCIENTIFIC REPORTS
(2018)
Letter
Urology & Nephrology
Bernard Jegou, David M. Kristensen
NATURE REVIEWS UROLOGY
(2019)
Article
Toxicology
Xavier Coumoul, Remi Servien, Ludmila Juricek, Yael Kaddouch-Amar, Yannick Lippi, Laureline Berthelot, Claire Naylies, Marie-Line Morvan, Jean-Philippe Antignac, Christele Desdoits-Lethimonier, Bernard Jegou, Marie Tremblay-Franco, Cecile Canlet, Laurent Debrauwer, Caroline Le Gall, Julie Laurent, Pierre-Antoine Gouraud, Jean-Pierre Cravedi, Elisabeth Jeunesse, Nicolas Savy, Kadidiatou Dandere-Abdoulkarim, Nathalie Arnich, Franck Foures, Jerome Cotton, Simon Broudin, Bruno Corman, Annick Moing, Berengere Laporte, Florence Richard-Forget, Robert Barouki, Peter Rogowsky, Bernard Salles
TOXICOLOGICAL SCIENCES
(2019)
Article
Biochemical Research Methods
Thomas A. Darde, Estelle Lecluze, Aurelie Lardenois, Isabelle Stevant, Nathan Alary, Frank Tuttelmann, Olivier Collin, Serge Nef, Bernard Jegou, Antoine D. Rolland, Frederic Chalmel
Article
Toxicology
Thu Ha Pham, Lohann Derian, Christine Kervarrec, Pierre-Yves Kernanec, Bernard Jegou, Fatima Smagulova, Aurore Gely-Pernot
TOXICOLOGICAL SCIENCES
(2019)
Article
Obstetrics & Gynecology
A. D. Rolland, B. Evrard, T. A. Darde, C. Le Beguec, Y. Le Bras, K. Bensalah, S. Lavoue, B. Jost, M. Primig, N. Dejucq-Rainsford, F. Chalmel, B. Jegou
HUMAN REPRODUCTION
(2019)
Article
Biology
M. Yefimova, E. Bere, A. S. Neyroud, B. Jegou, N. Bourmeyster, C. Ravel
Review
Medicine, Research & Experimental
Antoine Buschiazzo, Marina Yefimova, Nicolas Bourmeyster, Alain Fautrel, Agnes Burel, Anne-Sophie Neyroud, Celine Pimentel, Sylvie Jaillard, Bernard Jegou, Celia Ravel
M S-MEDECINE SCIENCES
(2019)
Article
Multidisciplinary Sciences
John E. Nielsen, Antoine D. Rolland, Ewa Rajpert-De Meyts, Christian Janfelt, Anne Jorgensen, Sofia B. Winge, David M. Kristensen, Anders Juul, Frederic Chalmel, Bernard Jegou, Niels E. Skakkebaek
SCIENTIFIC REPORTS
(2019)
Article
Andrology
Marina G. Yefimova, Antoine Buschiazzo, Agnes Burel, Marie-Therese Lavault, Celine Pimentel, Guilhem Jouve, Sylvie Jaillard, Bernard Jegou, Nicolas Bourmeyster, Celia Ravel
ASIAN JOURNAL OF ANDROLOGY
(2019)
