Article
Construction & Building Technology
Samuel J. Cochran, Luis Acosta, Adnan Divjan, Angela R. Lemons, Andrew G. Rundle, Rachel L. Miller, Edward Sobek, Brett J. Green, Matthew S. Perzanowski, Karen C. Dannemiller
Summary: There is significant seasonal variation in total fungal concentration and concentration of select allergenic species. Indoor relative humidity and temperature may underlie these associations.
BUILDING AND ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Angelica Papanicolaou, Hao Wang, Jonathan McQualter, Christian Aloe, Stavros Selemidis, Catherine Satzke, Ross Vlahos, Steven Bozinovski
Summary: Allergic airway disease diminishes the control of pneumococcal lung infections, and exposure to house dust mites exacerbates the immune response, leading to more severe infections and increased airway hyperresponsiveness.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Veterinary Sciences
Awol M. Assen, Peter J. Groves, Ashley Etherington, Priscilla F. Gerber, Margaret Sexton, Sarah Williamson, Stephen W. Walkden-Brown
Summary: Population-level sampling using ILTV in poultry dust can assess ILT vaccination outcomes. The method was applied in meat chicken flocks and showed that ILTV infection is common before vaccination. Collecting dust samples proved useful in interpreting vaccination outcomes and ILTV status.
Article
Environmental Sciences
A. B. Obeng, M. Del Rio, C. Costa, C. Chavarria, C. Rodriguez, M. B. Galkaduwa, C. Wekumbura, K. Gamage, G. M. Hettiarachchi, W. Hargrove, C. Sobin
Summary: This study tested the comparability of a portable X-ray fluorescence device with Inductively Coupled Plasma Mass Spectrometry in measuring lead concentrations in dust wipe samples, and the results showed a good agreement at lower lead concentrations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Patricia Macchiaverni, Ulrike Gehring, Akila Rekima, Alet H. Wijga, Valerie Verhasselt
Summary: This study investigated the relationship between exposure to house dust mite Der p 1 allergen from different sources during infancy and IgE levels and asthma outcomes in children. The findings suggest that exposure to Der p 1 through human milk is associated with high levels of serum IgE in childhood, while exposure from mattress dust is not.
Article
Allergy
Mariana Farraia, Ines Paciencia, Francisca Castro Mendes, Joao Cavaleiro Rufo, Mohamed H. Shamji, Ioana Agache, Andre Moreira
Summary: This study compared the cost-effectiveness of allergen immunotherapy (AIT) to standard treatment in children with allergic asthma. The results showed that AIT, especially when administered subcutaneously, was cost effective in reducing asthma exacerbations and medication use.
Article
Allergy
Xiaofan Tu, Richard Y. Kim, Alexandra C. Brown, Emma De Jong, Bernadette Jones-Freeman, Khadem Ali, Henry M. Gomez, Kurtis F. Budden, Malcolm R. Starkey, Guy J. M. Cameron, Svenja Loering, Duc H. Nguyen, Prema Mono Nair, Tatt Jhong Haw, Charlotte A. Alemao, Alen Faiz, Hock L. Tay, Peter A. B. Wark, Darryl A. Knight, Paul S. Foster, Anthony Bosco, Jay C. Horvat, Philip M. Hansbro, Chantal Donovan
Summary: This study successfully replicated the characteristics of asthma and COPD in an experimental model, and identified transcriptomic changes and disease mechanisms in experimental ACO, providing new clues for the treatment of ACO.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Respiratory System
Xiaofan Tu, Henry M. Gomez, Richard Y. Kim, Alexandra C. Brown, Emma de Jong, Izabela Galvao, Alen Faiz, Anthony Bosco, Jay C. Horvat, Philip Hansbro, Chantal Donovan
Summary: Lung transcriptomics studies have provided valuable information in asthma research, but it is important to understand the individual contributions of the airway and parenchyma in disease development. This study used a house dust mite-induced asthma model to analyze the transcriptomics of the airway and parenchyma. The results identified several transcription factors that regulate gene expression in these compartments, and further investigation showed that inhibiting the lung SPI1 response had positive effects on key disease outcomes. This study highlights the importance of SPI1 in experimental asthma and suggests its potential as a target for treatment.
RESPIRATORY RESEARCH
(2023)
Article
Environmental Sciences
Chaowen Huang, Dongyan Zheng, Chunlai Fu, Ziwei Cai, He Zhang, Zhefan Xie, Lishan Luo, Huifang Li, Yanming Huang, Jialong Chen
Summary: Airway epithelial barrier dysfunction is crucial in asthma pathogenesis and leads to enhanced downstream inflammatory signaling. S100 calcium binding protein A4 (S100A4), which promotes metastasis, has been found as an effective inflammatory factor elevated in bronchoalveolar lavage fluid in asthmatic mice. Vascular endothelial growth factor-A (VEGFA) is considered a vital regulator in vascular physiological activities. This study explored the function of S100A4 and VEGFA in an asthma model induced by house dust mite (HDM) extracts. The results demonstrate that secreted S100A4 causes epithelial barrier dysfunction, airway inflammation, and the release of T-helper 2 cytokines through the activation of VEGFA/VEGFR2 signaling pathway, and can be partially reversed by S100A4 polyclonal antibody, niclosamide, and S100A4 knockdown, suggesting a potential therapeutic target for airway epithelial barrier dysfunction in asthma.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Respiratory System
Tsutomu Saito, Tomohiro Ichikawa, Tadahisa Numakura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Koji Murakami, Shun Yamanaka, Yusaku Sasaki, Yorihiko Kyogoku, Koji Itakura, Hirohito Sano, Katsuya Takita, Rie Tanaka, Tsutomu Tamada, Masakazu Ichinose, Hisatoshi Sugiura
Summary: This study found that PGC-1 alpha is involved in the disruption of airway barrier function induced by aeroallergens through the PAR2/TLR4 pathway. Modulation of this pathway could be a novel approach for asthma treatment.
RESPIRATORY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Sudartip Areecheewakul, Andrea Adamcakova-Dodd, Zeb R. Zacharias, Xuefang Jing, David K. Meyerholz, Kevin L. Legge, Jon C. D. Houtman, Patrick T. O'Shaughnessy, Peter S. Thorne, Aliasger K. Salem
Summary: This study investigated the immunomodulatory effects of inhalation exposure to copper oxide nanoparticles (CuO NPs) in different immune conditions. The results showed that CuO NP exposure decreased T(H)1 and T(H)2 cells and increased T-bet(+) Treg cells in healthy mice. However, CuO NP inhalation exposure resulted in decreased T(H)2 responses and increased T-bet(+) Treg cells in mice with house dust mite (HDM) asthma, and increased T(H)2 cells in AIT-treated asthmatic mice.
Article
Allergy
Erika Mendez-Enriquez, Perla Abigail Alvarado-Vazquez, Willem Abma, Oscar E. Simonson, Sergey Rodin, Thorsten B. Feyerabend, Hans-Reimer Rodewald, Andrei Malinovschi, Christer Janson, Mikael Adner, Jenny Hallgren
Summary: This study found that mast cells release serotonin, which enhances bronchoconstriction and AHR. Mast cells play a key role in the pathogenesis of asthma, and M3-directed treatments may also act by targeting mast cells.
Article
Biochemistry & Molecular Biology
Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Michelle E. Armstrong, Seamas C. Donnelly, Karen English
Summary: The expression of macrophage migration inhibitory factor (MIF) is controlled by a functional promoter polymorphism, where the number of tetranucleotide repeats (CATTn) corresponds to the level of MIF expression. Using a pre-clinical model of allergic asthma, novel humanized MIF mice with increasing CATT repeats (CATT5 and CATT7) were employed to study airway inflammation. The results showed that high expression of human MIF in CATT7 mice led to a severe asthma phenotype, which could be mitigated by the MIF inhibitor SCD-19. This study provides a reproducible model for studying asthma airway remodeling and suggests a potential role of MIF in driving this process.
Article
Immunology
Verena M. Merk, Truong San Phan, Alice Wiedmann, Rowan S. Hardy, Gareth G. Lavery, Thomas Brunner
Summary: The local synthesis of glucocorticoids in the lung plays an important role in the regulation of allergic airway inflammation, particularly in HDM-induced airway hypersensitivity, by controlling Toll-like receptor 4 signaling and cytokine/chemokine secretion to influence Th17-type immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Michelle E. Armstrong, Seamas C. Donnelly, Karen English
Summary: Macrophage migration inhibitory factor (MIF) expression is affected by a functional promoter polymorphism, with the number of CATT repeats correlating to MIF expression level. In a pre-clinical model of allergic asthma, mice with increasing CATT repeats (CATT(5) and CATT(7)) showed varying degrees of airway inflammation. The potent MIF inhibitor SCD-19 was able to mitigate the pathophysiology observed in CATT(7) mice, indicating the important role of endogenous human MIF expression in airway inflammation severity.
Letter
Engineering, Environmental
Kouji H. Harada, Mariko Harada Sassa, Naomichi Yamamoto
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Siyu Xu, Naomichi Yamamoto
Article
Chemistry, Multidisciplinary
Nopadol Precha, Wissanupong Kliengchuay, Cheolwoon Woo, Naomichi Yamamoto, Kraichat Tantrakarnapa
APPLIED SCIENCES-BASEL
(2020)
Article
Genetics & Heredity
Cheolwoon Woo, Naomichi Yamamoto
ENVIRONMENTAL MICROBIOME
(2020)
Article
Multidisciplinary Sciences
Naohide Shinohara, Cheolwoon Woo, Naomichi Yamamoto, Kazuhiro Hashimoto, Hiroko Yoshida-Ohuchi, Yuji Kawakami
Summary: Culture-independent DNA sequencing and culture-dependent morphological identification techniques were compared to characterize house dust-borne fungal communities, revealing significant correlations and biases in detection. The study highlighted the need for considering and amending biases when using these methods in future fungal ecological studies.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Yumiko Okamoto, Natsumi Ichinohe, Cheolwoon Woo, Sung-Yong Han, Hyeong-Hoo Kim, Sakura Ito, Chiho Nakamura, Junpei Kumura, Kentaro Nagaoka, Naomichi Yamamoto
Summary: The gut microbiota of captive Eurasian otters shows taxonomic and functional differences by age, likely attributed to changes in diet composition throughout their life stages. This study provides baseline information regarding the gut microbiota of Eurasian otters for the first time.
ARCHIVES OF MICROBIOLOGY
(2021)
Letter
Allergy
Shanika Nanayakkara, Naomichi Yamamoto, Kouji H. Harada
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Priyanka Kumari, Binu Mani Tripathi, Ke Dong, Kyung Yeon Eo, Woo-Shin Lee, Junpei Kimura, Naomichi Yamamoto
Summary: This study investigates the risks and ecology of antimicrobial resistance genes (ARGs) in the environment by analyzing the feces of wildlife. The study finds significant differences in bacterial taxonomy composition and resistomes between different animal hosts, as well as selective correlations between certain ARGs and bacteria. This research provides important baseline information for conservation efforts and assessing health risks posed by ARGs and bacterial pathogens from wildlife.
Article
Multidisciplinary Sciences
Cheolwoon Woo, Priyanka Kumari, Kyung Yeon Eo, Woo-Shin Lee, Junpei Kimura, Naomichi Yamamoto
Summary: This study used DNA metabarcoding to investigate the fecal contents of raccoon dogs and developed a blocking oligonucleotide. It was found that raccoon dogs mainly feed on fishes such as Cyprinidae and insects such as mole crickets in the study area. This study provided baseline information on DNA metabarcoding and can help future research better understand the diet habits and ecology of raccoon dogs.
Article
Entomology
Cheolwoon Woo, Mohammad Imtiaj Uddin Bhuiyan, Donghyun Kim, Priyanka Kumari, Seung-Kyung Lee, Ji Young Park, Ke Dong, Kiyoung Lee, Naomichi Yamamoto
Summary: House dust mites are closely associated with certain types of fungi in indoor dust, especially xerophilic fungi. Understanding the microbial ecology in house dust is crucial for understanding the etiology of human diseases such as allergies.
EXPERIMENTAL AND APPLIED ACAROLOGY
(2022)
Article
Multidisciplinary Sciences
Cheolwoon Woo, Priyanka Kumari, Kyung Yeon Eo, Woo-Shin Lee, Junpei Kimura, Naomichi Yamamoto
Summary: The diet of leopard cats in South Korea's inland areas was investigated using vertebrate mitochondrial 12S rRNA gene sequencing and shotgun metagenomic sequencing. The feces contained not only vertebrate DNA but also arthropods and plants, although shotgun metagenomic sequencing was often erroneous at low taxonomic levels. On the other hand, vertebrate mitochondrial 12S rRNA gene sequencing accurately identified the prey at the genus level. The combination of these two sequencing methods provided accurate information about the overall dietary content and vertebrate prey of leopard cats.
Article
Multidisciplinary Sciences
Seung-Kyung Lee, Cheolwoon Woo, Eun Ju Lee, Naomichi Yamamoto
Summary: This study investigated the dietary composition of the Korean water deer using high-throughput sequencing and found that they are adaptable and feed on a wide variety of woody plants. Understanding their feeding habits is important for the management and conservation of the Korean water deer.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Kevin K. Newsham, Birgitte Kortegaard Danielsen, Elisabeth Machteld Biersma, Bo Elberling, Guy Hillyard, Priyanka Kumari, Anders Prieme, Cheolwoon Woo, Naomichi Yamamoto
Summary: The effects of warming and increased water availability on soil microbes in the High Arctic are not well understood. An experiment conducted on Svalbard revealed that a rise in summertime soil temperature and irrigation led to increased greenhouse gas emissions and bacterial abundance.
Article
Ecology
Cheolwoon Woo, Mohammad Imtiaj Uddin Bhuiyan, Kyung Yeon Eo, Woo-Shin Lee, Junpei Kimura, Naomichi Yamamoto
Summary: This study examined the fecal parasites of carnivorous wildlife in Korea and found host-specific and prey-associated parasite species. The composition of the parasitome varied between host animals and was influenced by their prey. Five zoonotic parasites known to infect humans were also identified, highlighting the potential for wildlife-associated zoonoses to increase with human-wildlife proximity due to urbanization.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-PARASITES AND WILDLIFE
(2023)
Article
Veterinary Sciences
Priyanka Kumari, Kyung Yeon Eo, Woo-Shin Lee, Junpei Kimura, Naomichi Yamamoto
Summary: The study found that zoonotic pathogens such as Giardia intestinalis, Toxoplasma gondii, and Leptospira wolffii are present in Korean wildlife, with leopard cats, raccoon dogs, and Eurasian otters serving as potential reservoirs. Regular monitoring of these pathogens in wildlife is essential to prevent infections in humans and livestock in Korea.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
