Article
Andrology
Fatemeh Anbari, Mohammad Ali Khalili, Abdul Munaf Sultan Ahamed, Esmat Mangoli, Ali Nabi, Fatemeh Dehghanpour, Mojdeh Sabour
Summary: This study compared sperm quality, DNA integrity, embryo development, and clinical outcomes between sperm samples prepared using Microfluidic Sperm Sorting (MSS) and Direct Swim Up (DSU) methods for intracytoplasmic sperm injection (ICSI). The results showed that MSS significantly improved sperm quality parameters and clinical outcomes compared to DSU.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Irene Hervas, Alberto Pacheco, Rocio Rivera-Egea, Maria Gil Julia, Ana Navarro-Gomezlechon, Nicolas Garrido
Summary: The study of 1339 couples undergoing 2759 IVF/ICSI cycles showed that high SDF did not affect reproductive success of unselected couples using autologous oocytes in IVF/ICSI cycles.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Environmental Sciences
Saihong Yan, Jun Wang, Ziting Zheng, Fenfen Ji, Liang Yan, Lihua Yang, Jinmiao Zha
Summary: Benzophenone-type ultraviolet (UV) filters (BPs) are commonly used in sunscreens, fragrances, and plastics, but they pose a great threat to aquatic organisms. This study investigated the toxicity and mechanism of BPs in Chinese rare minnows and found that they caused significant alterations in cell cycle, DNA replication, and repair pathways, as well as DNA damage and apoptosis.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Saihong Yan, Rui Chen, Miao Wang, Jinmiao Zha
Summary: The study revealed that exposure to carbamazepine induced DNA damage and apoptosis in Chinese rare minnows through the Ras/Raf/ERK/p53 signaling pathway.
ENVIRONMENTAL POLLUTION
(2021)
Article
Endocrinology & Metabolism
Mei Tian, Suimin Zeng, Sufen Cai, Christoph Reichetzeder, Xiaoli Zhang, Chenjun Yin, Weihong Kuang, Kexin Cheng, Yao Jiang, Mingqiu Tao, Yuan Zeng, Ge Lin, Jian Li, Fei Gong, Berthold Hocher
Summary: The study found a weak correlation between free and total 25(OH)VitD, and in infertile females undergoing IVF or ICSI treatment, free 25(OH)VitD showed slight correlations with fertility parameters.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zeliha Fazliogullari, Ahmet Kagan Karabulut, Nadire Unver Dogan, Ismihan Ilknur Uysal, Hasan Acar
Summary: The study revealed that prednisolone does not have developmental toxicity on rat embryos with a maximum safe dose of 20 μg/ml, while azathioprine showed toxicity and teratogenic effects starting at 1 μg/ml. Mycophenolate mofetile exhibited dose-dependent toxic and teratogenic effects at doses lower than normal clinical ones.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Health Care Sciences & Services
Ioana Zaha, Petronela Naghi, Liana Stefan, Cosmina Bunescu, Mihaela Radu, Mariana Eugenia Muresan, Mircea Sandor, Liliana Sachelarie, Anca Huniadi
Summary: The microfluidic sperm selection method was found to improve the outcomes of in vitro fertilization (IVF) procedures. This method, which selects spermatozoa with the lowest DNA fragmentation rate, resulted in higher blastocyst rates and clinical pregnancy rates. It has the potential to be widely used in intracytoplasmic sperm injection (ICSI) and improve the workflow of standard IVF, reducing intervention by laboratory personnel and providing more consistent incubation conditions.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Infectious Diseases
O. Escobar-Chavarria, R. Cossio-Bayugar, P. Ramirez-Noguera, M. G. Prado-Ochoa, A. M. Velazquez-Sanchez, M. A. Munoz-Guzman, E. Angeles, F. Alba-Hurtado
Summary: Ethyl-4-bromophenylcarbamate (LQM 919) and ethyl-4-chlorophenylcarbamate (LQM 996) have the ability to induce apoptosis in Rhipicephalus microplus ovarian cells, as well as tick and mammalian cell cultures, displaying a significant acaricidal effect.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Andrology
Arief Boediono, Nining Handayani, Henny Natalya Sari, Nuraeni Yusup, Wahyu Indrasari, Arie A. Polim, Ivan Sini
Summary: The study found that IMSI and ICSI resulted in embryos with similar morphokinetics, but IMSI had a lower incidence of multinucleation compared to ICSI. However, neither method showed an improvement in the proportion of chromosomally euploid embryos.
Article
Environmental Sciences
Francielen Barroso Aragao, Ian Drumond Duarte, Dayana Effgen Fantinato, Iasmini Nicoli Galter, Graciele Lurdes Silveira, Gabriela Barreto dos Reis, Larissa Fonseca Andrade-Vieira, Silvia Tamie Matsumoto
Summary: The study showed that a tebuconazole-based fungicide may have phytotoxic, cytotoxic, and genotoxic effects on the roots and meristematic cells of L. sativa at certain concentrations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Veterinary Sciences
Jordi Ribas-Maynou, Marc Llavanera, Yentel Mateo-Otero, Estela Garcia-Bonavila, Ariadna Delgado-Bermudez, Marc Yeste
Summary: This study analyzed eight techniques assessing chromatin damage in pig sperm and found that the extent of chromatin damage is significantly correlated with the percentage of sperm with fragmented DNA in direct methods, but not in indirect ones. The results suggest that there are differences in interpreting sperm chromatin damage between indirect and direct techniques.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Medicine, General & Internal
Sandrine Chamayou, Filippo Giacone, Rossella Cannarella, Antonino Guglielmino
Summary: The intracytoplasmic sperm injection (ICSI) technique was invented to address severe male infertility caused by altered sperm parameters. It is now widely used worldwide for couple infertility treatment. ICSI can be performed using any available spermatozoon, regardless of motility, morphology, or quantity. Published data shows that ICSI accelerates zygote kinetics and leads to higher fertilization rates and more blastocysts for clinical use compared to conventional IVF. Various sperm and spermatozoa characteristics, such as parameters, morphology, vitality, DNA content, RNA content, epigenetics, and recovery site, have different impacts on fertilization, blastocyst rates, and embryo kinetics. While ICSI is the most common solution for couple infertility, understanding the causes of male infertility is crucial for producing competent spermatozoa that contribute to normal embryonic development and healthy offspring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Sara J. Bergenheim, Marte Saupstad, Nina Pistoljevic, Anders Nyboe Andersen, Julie Lyng Forman, Kristine Lossl, Anja Pinborg
Summary: The number of frozen embryo transfer cycles in Europe has been steadily increasing, with immediate FET potentially leading to higher live birth and pregnancy rates compared to postponed FET. However, more high-quality evidence from randomized controlled trials is needed to confirm these findings and determine the best clinical practice.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Multidisciplinary Sciences
Steven A. Chambers, Mathew Newman, Melissa M. Frangie, Alena Savenka, Alexei G. Basnakian, Mohammad A. Alam
Summary: The discovery of chimeric anti-melanoma agents with potent growth suppressor effects on melanoma cells was reported. These agents induced cell apoptosis through multiple pathways and showed greater cytotoxicity to melanoma cells compared to the commonly used agent dacarbazine.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yakun Wang, Huarong Li, Jie Wei, Kunhao Hong, Qiaoyan Zhou, Xiaoli Liu, Xiaoyou Hong, Wei Li, Chao Liu, Xinping Zhu, Lingyun Yu
Summary: This study investigated the physiological changes in Macrobrachium rosenbergii under acute salinity stress and found that hemolymph osmolality increased, physiological metabolism decreased, antioxidant capacity and immune capacity weakened, and apoptosis increased. These findings provide important insights into the mechanisms underlying the response to acute salinity stress and will contribute to improving the aquaculture and management practices of M. rosenbergii.
