Article
Plant Sciences
Woo Sung Park, Kyung Ah Koo, Ji-Yeong Bae, Hye-Jin Kim, Dong-Min Kang, Ji-Min Kwon, Seung-Mann Paek, Mi Kyeong Lee, Chul Young Kim, Mi-Jeong Ahn
Summary: A study analyzed the content of seven lignans in Schisandra chinensis fruit using HPLC-DAD, revealing that seeds had the highest content. The addition of oligosaccharide/white sugar to fermented beverages significantly increased lignan content.
Review
Chemistry, Multidisciplinary
Shunyi Yang, Chunhong Yuan
Summary: Schisandra chinensis is a climbing plant widely used in traditional Chinese herb, with over 200 chemical compounds identified, showing various biological activities such as anti-cancer and anti-inflammatory effects. Further studies are needed to explore more active principles and mechanisms of this plant.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Karolina Jafernik, Halina Ekiert, Agnieszka Szopa
Summary: "A Review of Schisandra henryi: Chemical Composition and Biological Properties" provides a comprehensive review of the research conducted on this endemic plant species in Yunnan, China. The chemical composition of S. henryi is similar to the well-known medicinal plant S. chinensis, and it exhibits various pharmacological properties. The study also highlights the biotechnological potential of S. henryi in in vitro cultures as an alternative source of raw material. This article summarizes the research on the chemical profile and diverse medicinal effects of S. henryi.
Article
Biochemistry & Molecular Biology
Agnieszka Szopa, Michal Dziurka, Pawel Kubica, Karolina Jafernik, Oliwia Siomak, Halina Ekiert
Summary: This study investigated the effect of different elicitors on lignan accumulation in microshoot cultures of female and male Schisandra rubriflora. The results showed that certain elicitors significantly increased lignan content.
Article
Plant Sciences
Shiqi Huang, Yuanyuan Liu, Yuze Li, Hao Fan, Wenli Huang, Chong Deng, Xiaomei Song, Dongdong Zhang, Wei Wang
Summary: Two new dibenzocyclooctadiene lignans, schisphenlignan M and N, along with nine known analogues, were isolated from the root bark of Schisandra sphenanthera. These lignans showed cytotoxic activities against human lung and colon cancer cell lines, indicating potential anti-cancer properties.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Plant Sciences
Yi-Qiang Zhang, Yan Liu, Bo Wen, Si-Yi Wang, Peng Jiang, Jia-Tong Wu, Juan Pan, Wei Guan, Hai-Xue Kuang, Bing-You Yang
Summary: Five schinortriterpenoids and seven lignans were isolated from the leaves of Schisandra chinensis. Among them, a new schinortriterpenoid and a new lignan were discovered. Their structures were determined through spectroscopic analysis. The cytotoxic activities of these compounds were evaluated, and compound 4 exhibited significant activity.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Plant Sciences
Ting-Yan Qiang, Jiu-Shi Liu, Yu-Qing Dong, Xin-Lu Mu, Yu Chen, Hong-Mei Luo, Ben-Gang Zhang, Hai-Tao Liu
Summary: This study identified an enzyme with catalytic activity from the Schisandraceae family and found the first functionally characterized enzyme, laying the foundation for further research on the complete biosynthetic pathway of dibenzocyclooctadiene lignans.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ewelina Sobstyl, Agnieszka Szopa, Michal Dziurka, Halina Ekiert, Hanna Nikolaichuk, Irena Maria Choma
Summary: The effect-directed detection (EDD) was conducted to evaluate the pharmacological properties of Schisandra rubriflora fruit and leaves extracts. The results showed that both fruit and leaf extracts exhibited antioxidant activity, with stronger inhibition of lipase and tyrosinase by the leaf extracts, and slightly higher inhibition of alpha-glucosidase and acetylcholinesterase (AChE) by the fruit extract. UHPLC-MS/MS analysis indicated the presence of potential anti-dementia compounds in the bioactive fractions. Gomisin N, schisanhenol, gomisin G, schisandrin A, and gomisin O were the dominant compounds in the fruit extract.
Article
Food Science & Technology
Trong Nguyen Nguyen, Yeong-Geun Lee, Hyoung-Geun Kim, Dahye Yoon, Jin Tae Jeong, Dae Young Lee, Nam-In Baek
Summary: A new dibenzocyclooctadiene lignan named gomisin M3 was isolated along with four known lignans using repeated column chromatography and preparative HPLC column chromatography. The chemical structures were determined based on MS, IR, and NMR data analysis, and the stereochemistry of atropisomers was confirmed through a CD experiment.
APPLIED BIOLOGICAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Shi-qi Liu, Yu-pei Yang, Nusrat Hussain, Yu-qing Jian, Bin Li, Yi-xing Qiu, Huang-he Yu, Hui-zhen Wang, Wei Wang
Summary: Liver injury is a pathological process characterized by cell degeneration and death, which can lead to serious diseases. The drug Bicylol, derived from Schisandra chinensis, shows potential in treating liver injury. This study aims to summarize the chemical properties, structure-activity relationship, and molecular mechanisms of dibenzocyclooctadiene lignans from the Schisandraceae family. Among 358 compounds analyzed, 37 dibenzocyclooctadiene lignans exhibited hepatoprotective effects. The active compounds mainly exert their effects through antioxidative stress, anti-inflammation, and autophagy pathways. This review provides valuable insights for future research on utilizing dibenzocyclooctadiene lignans from the Schisandraceae family.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Pham Hai Yen, Nguyen Huy Hoang, Nguyen Xuan Nhiem, Phan Thi Thanh Huong, Duong Thi Dung, Nguyen Thi Cuc, Nguyen The Cuong, Bui Van Thanh, Bui Huu Tai, Phan Van Kiem
Summary: Five new dimethylbutyrylated dibenzocyclooctadiene lignans, named schisandracaurins A-E, were isolated from Schisandra cauliflora using separation and chromatographic techniques. Their structures were determined by extensive analyses of HR-ESI-MS, NMR, and ECD spectra. The schisandracaurins A-E potentially inhibited NO production in LPS-activated RAW264.7 cells with their IC50 values ranging from 21.4 to 30.3 μM.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Lu-Lu Deng, Xu-Dong Xie, Jiang Li, Dao-Ping Wang, Xiao-Jiang Hao, Gang Chen, Shu-Zhen Mu
Summary: The study clarified the hepatoprotective constituents of Fructus Schizandrae chinensis by identifying key components such as schisandrin B, schisandrin A, and schisandrol B which play significant roles in promoting liver protection. The results confirmed that a combination of these key components in optimal ratios showed better activity than any individual compound, highlighting the synergistic effects of traditional Chinese medicine.
Article
Plant Sciences
Tran Tuan Anh, Vu Van Doan, Vu Thi Xuan, Bui Quang Tuan, Bui Huu Tai, Phan Van Kiem, Nguyen Xuan Nhiem, Nguyen The Cuong, SeonJu Park, Yohan Seo, Wan Namkung, Seung Hyun Kim, Nguyen Thi Mai
Summary: Two new compounds, schisandrulata A and schisandrulata B, along with nine known compounds were isolated from Schisandra perulata leaves. Compounds 1, 4, 7, and 9 showed potent cytotoxic activity against CAL27 and MDA-MB231 cell lines, indicating their potential as anticancer agents.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Yan-hua Sheng, Rui Wang, Yi-kai Wang, Meng-meng Li, Fang-xin Liu, Xin Huang, Chang-bao Chen
Summary: This study evaluated the influence of drying on the chemical components of Schisandra chinensis fruit using targeted metabolomics analysis. The results showed that the contents of lignans, organic acids, and oligosaccharides varied with different drying methods and temperatures. Based on comprehensive considerations, hot air drying at 50 degrees C was found to be more suitable for the processing of Schisandra chinensis fruit.
JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Bui Huu Tai, Pham Hai Yen, Nguyen Huy Hoang, Phan Thi Thanh Huong, Nguyen Viet Dung, Bui Van Thanh, Nguyen The Cuong, Ngo Anh Bang, Nguyen Xuan Nhiem, Phan Van Kiem
Summary: In this study, five new compounds and three known compounds were isolated from the stems of Kadsura induta, and their structures were determined. The newly isolated compounds showed good binding affinity to the active sites of iNOS and TNF-alpha proteins, and they also exhibited the ability to inhibit NO production.
