期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 13, 期 5, 页码 393-399出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2011.565748
关键词
Schisandreae; Schisandra rubriflora; fruits; dibenzocyclooctadiene lignans; anti-HIV-1 activity
资金
- National Natural Science Foundation of China [30830115, 20802082]
- Chinese Academy of Sciences [KSCX1-YW-R-24]
- 973 programs [2009CB522300, 2009CB940900]
- Young Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]
Two new dibenzocyclooctadiene lignans, rubrilignans A and B (1, 2), together with 17 known ones, were isolated from the fruits of Schisandra rubriflora. The structures of 1 and 2 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also evaluated for their anti-HIV-1 activities and showed weak anti-HIV-1 activity with EC50 values of 2.26 and 1.82g/ml, and therapeutic index values of 35.5 and 18.6, respectively.
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