Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation

Chemical Protein Polyubiquitination Reveals the Role of a Noncanonical Polyubiquitin Chain in DNA Damage Tolerance

(2014) Kun Yang et al.   ACS Chemical Biology

Evolved Sequence Contexts for Highly Efficient Amber Suppression with Noncanonical Amino Acids

(2014) Moritz Pott et al.   ACS Chemical Biology

Dissecting Ubiquitin Signaling with Linkage-Defined and Protease Resistant Ubiquitin Chains

(2014) Tatjana Schneider et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nonenzymatic Rubylation and Ubiquitination of Proteins for Structural and Functional Studies

(2014) Rajesh K. Singh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Minimal Tags for Rapid Dual-Color Live-Cell Labeling and Super-Resolution Microscopy

(2014) Ivana Nikić et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nonenzymatic Polyubiquitination of Expressed Proteins

(2014) Hosahalli P. Hemantha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Bioconjugation of a Murine Dihydrofolate Reductase Enzyme by Copper(I)-Catalyzed Azide-Alkyne Cycloaddition with Retained Activity

(2014) Sung In Lim et al.   PLoS One

A Facile Strategy for Selective Incorporation of Phosphoserine into Histones

(2013) Sangsik Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving bioorthogonal protein ubiquitylation by click reaction

(2013) Daniel Schneider et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nonenzymatic assembly of branched polyubiquitin chains for structural and biochemical studies

(2013) Emma K. Dixon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Genetically Encoded Chemical Probes in Cells Reveal the Binding Path of Urocortin-I to CRF Class B GPCR

(2013) Irene Coin et al.   CELL

Chemoselective Immobilization of Proteins by Microcontact Printing and Bio-orthogonal Click Reactions

(2013) Zachary P. Tolstyka et al.   CHEMBIOCHEM

Synthetic polyubiquitinated  -Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

(2013) M. Haj-Yahya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomically Recoded Organisms Expand Biological Functions

(2013) M. J. Lajoie et al.   SCIENCE

DUB-Resistant Ubiquitin to Survey Ubiquitination Switches in Mammalian Cells

(2013) Miklós Békés et al.   Cell Reports

Nonenzymatic Polymerization of Ubiquitin: Single-Step Synthesis and Isolation of Discrete Ubiquitin Oligomers

(2012) Vivian H. Trang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemistry and Biology of the Ubiquitin Signal

(2012) Liat Spasser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

(2012) Chayasith Uttamapinant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Polymerization Behavior of a Bifunctional Ubiquitin Monomer as a Function of the Nucleophile Site and Folding Conditions

(2012) Tal Moyal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploiting Ligand-Protein Conjugates to Monitor Ligand-Receptor Interactions

(2012) Hirohito Haruki et al.   PLoS One

Total Chemical Synthesis of a 304 Amino Acid K48-Linked Tetraubiquitin Protein

(2011) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Synthesis of Ubiquitinated Peptides with Varying Lengths and Types of Ubiquitin Chains to Explore the Activity of Deubiquitinases

(2011) Sudhir N. Bavikar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanded Click Conjugation of Recombinant Proteins with Ubiquitin-Like Modifiers Reveals Altered Substrate Preference of SUMO2-Modified Ubc9

(2011) Stefanie Sommer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Linear polyubiquitin chains

(2011) Kazuhiro Iwai   CELL CYCLE

Generation of a Mono-ubiquitinated PCNA Mimic by Click Chemistry

(2011) Silvia Eger et al.   CHEMBIOCHEM

Click synthesis of ubiquitin dimer analogs to interrogate linkage-specific UBA domain binding

(2011) Nadine D. Weikart et al.   CHEMICAL COMMUNICATIONS

Nonenzymatic Assembly of Natural Polyubiquitin Chains of Any Linkage Composition and Isotopic Labeling Scheme

(2011) Carlos Castañeda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diels–Alder Cycloaddition for Fluorophore Targeting to Specific Proteins inside Living Cells

(2011) Daniel S. Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites

(2011) David B F Johnson et al.   Nature Chemical Biology

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

(2011) E. Arbely et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Site-Specific Incorporation ofp-Propargyloxyphenylalanine in a Cell-Free Environment for Direct Protein−Protein Click Conjugation

(2010) Bradley C. Bundy et al.   BIOCONJUGATE CHEMISTRY

Nonhydrolyzable Ubiquitin−Isopeptide Isosteres as Deubiquitinating Enzyme Probes.

(2010) Anitha Shanmugham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Defined Ubiquitin Dimers

(2010) Silvia Eger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis

(2010) Junjun Chen et al.   Nature Chemical Biology

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

(2010) Satpal Virdee et al.   Nature Chemical Biology

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation

(2010) Champak Chatterjee et al.   Nature Chemical Biology

AnIn VivoCovalent TMP-Tag Based on Proximity-Induced Reactivity

(2009) Sarah S. Gallagher et al.   ACS Chemical Biology

Synthesis and Microcontact Printing of Dual End-Functionalized Mucin-like Glycopolymers for Microarray Applications

(2009) Kamil Godula et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis and Optimization of Copper-Catalyzed Azide–Alkyne Cycloaddition for Bioconjugation

(2009) Vu Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional Ubiquitin Conjugates with Lysine-ε-Amino-Specific Linkage by Thioether Ligation of Cysteinyl-Ubiquitin Peptide Building Blocks

(2009) Ji Eun Jung et al.   BIOCONJUGATE CHEMISTRY

RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells

(2009) Jaehoon Kim et al.   CELL

An Enhanced System for Unnatural Amino Acid Mutagenesis in E. coli

(2009) Travis S. Young et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetic Encoding and Labeling of Aliphatic Azides and Alkynes in Recombinant Proteinsviaa Pyrrolysyl-tRNA Synthetase/tRNACUAPair and Click Chemistry

(2009) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

Site-Specific Modification ofCandida antarcticaLipase B via Residue-Specific Incorporation of a Non-Canonical Amino Acid

(2008) Sanne Schoffelen et al.   BIOCONJUGATE CHEMISTRY

An Engineered Protein Tag for Multiprotein Labeling in Living Cells

(2008) Arnaud Gautier et al.   CHEMISTRY & BIOLOGY

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE

Click Chemistry, A Powerful Tool for Pharmaceutical Sciences

(2008) Christopher D. Hein et al.   PHARMACEUTICAL RESEARCH

Synthesis of Modified DNA by PCR with Alkyne-Bearing Purines Followed by a Click Reaction

(2007) Philipp M. E. Gramlich et al.   ORGANIC LETTERS