Review
Biochemistry & Molecular Biology
Hyeji Jeon, Su Min Seo, Tae Wan Kim, Jaesung Ryu, Hyejeong Kong, Si Hyeong Jang, Yong Soo Jang, Kwang Seock Kim, Jae Hoon Kim, Seongho Ryu, Seob Jeon
Summary: The aim of this study was to develop a new diagnostic biomarker for identifying specific serum exosomal miRNAs in epithelial ovarian cancer (EOC) and investigate the target gene of the miRNA to understand the molecular mechanisms involved. The results showed that miRNA-1290 was significantly overexpressed in serum exosomes and tissues of EOC patients compared to those with benign ovarian neoplasms. Furthermore, the study suggested that serum exosomal miR-1290 could be considered as a potential biomarker for differentiating EOC from benign ovarian neoplasms, and SOCS4 might be a potential target gene of miR-1290 in EOC.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Samadian
Summary: miR-1290, a crucial member of the miRNA family, is involved in regulating the expression of multiple genes and interacting with various molecular pathways and genes, potentially impacting the development of malignancies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Reza Kalhori, Masoud Soleimani, Ehsan Arefian, Ali Mohammad Alizadeh, Kamran Mansouri, Javier Echeverria
Summary: miR-1290 is dysregulated in many cancers and plays a crucial role in their development, making it a potential diagnostic and therapeutic target. This systematic review study also discussed how miR-1290 alters the expression of genes related to cancer development and resistance to chemo-radiation, as well as the regulatory effect of natural products on miR-1290 expression and its interaction with lncRNAs.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Oncology
Liyi Xu, Yangke Cai, Xiao Chen, Yongliang Zhu, Jianting Cai
Summary: The study suggests that circulating miR-1290 may serve as a potential biomarker for diagnosis and monitoring of gastrointestinal cancer. This miRNA is expressed and secreted by gastrointestinal tumor cells, associated with various clinical characteristics, and provides different levels of sensitivity and specificity in different cancer types.
Article
Cell Biology
Shuo Wang, Peng Du, Yudong Cao, Jinchao Ma, Xiao Yang, Ziyi Yu, Yong Yang
Summary: Cancer-associated fibroblasts (CAFs) play important roles in promoting tumor growth and metastasis in prostate cancer (PC) through the transfer of exosomes. This study reveals that the exosomal miR-1290 from CAFs enhances PC cell growth and metastasis by inhibiting GSK3 beta/beta-catenin signaling.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Amrutha Menon, Noraini Abd-Aziz, Kanwal Khalid, Chit Laa Poh, Rakesh Naidu
Summary: This review focuses on the role of miRNA in cancer, therapeutic approaches with miRNAs, and effective delivery into the system. Patents and ongoing clinical trials for miRNA therapy are also summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qian Zhao, Lei Shen, Jinhui Lue, Heying Xie, Danni Li, Yuanyuan Shang, Liqun Huang, Lingyu Meng, Xuefeng An, Jieru Zhou, Jing Han, Zuoren Yu
Summary: A miRNA model for the diagnosis of breast cancer using blood samples was developed, showing high sensitivity and specificity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, General & Internal
Megha Lal, Asgar Hussain Ansari, Anurag Agrawal, Arijit Mukhopadhyay
Summary: The MiR-379/656 cluster shows potential for diagnostic and prognostic use in breast cancer, with Basal and Luminal B subtypes demonstrating the most effective predictive power.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Piero Di Battista, Federica Lovisa, Enrico Gaffo, Ilaria Gallingani, Carlotta C. Damanti, Anna Garbin, Lavinia Ferrone, Elisa Carraro, Marta Pillon, Luca Lo Nigro, Rossella Mura, Marco Pizzi, Vincenza Guzzardo, Angelo Paolo Dei Tos, Alessandra Biffi, Stefania Bortoluzzi, Lara Mussolin
Summary: This study identified significant dysregulation of miRNAs in pediatric ALK-positive ALCL through RNA sequencing, with particular focus on the association of miR-214-5p down-regulation with aggressive non-common histology. These findings suggest that the level of miR-214-5p may help refine prognostic stratification in pediatric ALK-positive ALCL.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Md. Hafiz Uddin, Mohammed Najeeb Al-Hallak, Philip A. Philip, Ramzi M. Mohammad, Nerissa Viola, Kay-Uwe Wagner, Asfar S. Azmi
Summary: Pancreatic cancer is the fourth leading cause of cancer death in the United States, with PDAC accounting for over 90% of cases and a low survival rate. MiRNAs have been identified as sensitive biomarkers in pancreatic cancer and are found in stable forms within exosomes. Further research on exosomal miRNAs is necessary for improved diagnostic, prognostic, and therapeutic strategies.
Article
Environmental Sciences
Prasenjit Mitra, Taru Goyal, Preeti Singh, Shailja Sharma, Praveen Sharma
Summary: The study found that miR-155 and miR-221 were significantly upregulated in occupationally lead-exposed workers, while miR-20b showed no significant difference. These miRNAs have the potential to trigger various genes and cellular pathways, highlighting the importance of miRNA dysregulation in the systemic effects of lead toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Guo-Dian Zheng, Zhi-Yuan Xu, Can Hu, Hang Lv, Hua-Xia Xie, Ting Huang, Yan-Qiang Zhang, Gui-Ping Chen, Yu-Fei Fu, Xiang-Dong Cheng
Summary: The study found that the expression of exosomal miR-590-5p is associated with the clinical stage, infiltration depth, and ki-67 expression level of GC. A decrease in exosomal miR-590-5p expression is correlated with a decrease in overall survival rate. As an independent predictor, miR-590-5p may inhibit cell migration and invasion, potentially serving as a biomarker for early detection and prediction of GC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jacek Kabzinski, Monika Maczynska, Ireneusz Majsterek
Summary: This article discusses the potential use of microRNAs in the diagnosis of head and neck squamous cell carcinoma, highlighting their application in radiotherapy and immunotherapy, as well as addressing the challenges and future research directions in developing this promising technology.
Review
Oncology
Hussein Al-Akhrass, Niki Christou
Summary: MiRNAs are increasingly important in the diagnosis, prognosis, and treatment decisions for colorectal cancers, with the need to identify the most sensitive and specific miRNAs through multicentric prospective studies for different goals. MiRNAs are becoming a key part of the healthcare management armamentarium for colorectal cancers due to their diversity and feasibility of use.
Article
Genetics & Heredity
Hualin Song, Tianjie Li, Jindong Sheng, Dan Li, Xiangyu Liu, Huiting Xiao, Hu Yu, Wenxin Liu, Ke Wang, Ying Chen
Summary: This study identified three necroptotic regulatory miRNAs related to endometrial cancer and developed a prognostic model based on these miRNAs. The model showed promising results in predicting the prognosis of endometrial cancer patients.
FRONTIERS IN GENETICS
(2022)
Review
Plant Sciences
Karol Rojek, Anna Serefko, Ewa Poleszak, Aleksandra Szopa, Andrzej Wrobel, Malgorzata Guz, Jianbo Xiao, Krystyna Skalicka-Wozniak
Summary: Aromatic grasses of Cymbopogon genus are widely used in traditional medicine, and their essential oils and active substances have been studied for potential therapeutic effects, especially in the treatment of neurological and mental disorders. Many scientists suggest that plants from the Cymbopogon genus are ideal candidates for further pharmaceutical research.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Oncology
Michal Kielbus, Radoslaw Rola, Bozena Jarosz, Witold Jeleniewicz, Marek Cybulski, Agnieszka Stenzel-Bembenek, Arkadiusz Podkowinski, Jolanta Smok-Kalwat, Krzysztof Polberg, Tomasz Trojanowski, Dawid Stefaniuk, Andrzej Stepulak
Summary: The study found a positive correlation between EGFRvIII and HERI in glioblastomas, with higher expression of HERI in benign meningiomas. However, in terms of overall patient survival, the mRNA levels of HERI or EGFRvIII are not independent prognostic factors.
ANTICANCER RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Agata Michalak, Halina Cichoz-Lach, Malgorzata Guz, Joanna Kozicka, Marek Cybulski, Witold Jeleniewicz
Summary: The study aimed to verify the role of platelet indices in alcohol-related liver cirrhosis and nonalcoholic fatty liver disease patients. Results showed significant differences in PDW and PCT levels between the patient groups compared to controls. MPV levels were also found to be decreased in the NAFLD group, suggesting potential diagnostic markers in ALC and NAFLD cases.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Agata Michalak, Malgorzata Guz, Joanna Kozicka, Marek Cybulski, Witold Jeleniewicz, Tomasz Lach, Halina Cichoz-Lach
Summary: This study investigated the blood markers in patients with alcohol-related liver cirrhosis and metabolic-associated fatty liver disease. The results showed that RDW and its derivatives may serve as valuable diagnostic markers and are associated with liver function deterioration in these patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Andrzej Pyra, Aneta Adamiak-Godlewska, Dorota Lewkowicz, Beata Balon, Marek Cybulski, Anna Semczuk-Sikora, Andrzej Semczuk
Summary: This retrospective study aimed to compare the expression of Ki67, PCNA, MCM3, and topoII alpha in the components of uterine carcinosarcomas (UC). The study found that the expression of these markers was related to clinical features and metastasis in UC.
Review
Biochemistry & Molecular Biology
Malgorzata Guz, Witold Jeleniewicz, Marek Cybulski
Summary: The role of non-coding RNAs (ncRNAs) in cancer is undeniable. Aberrant expression of ncRNAs, including circular RNAs (circRNAs) and microRNAs (miRNAs), is involved in the molecular mechanisms of carcinogenesis. CircRNAs, as a part of the competing endogenous RNA (ceRNAs) network, play a central role in regulating the accessibility of miRNAs to their mRNA targets. The imbalance between circRNAs and miRNAs is crucial in various pathologies, including cancer. This review focuses on the interaction between circRNAs and miR-141, a well-known member of the miR-200 family, in malignant transformation, highlighting the biological role of circRNA/miR-141/mRNA networks as a potential target for future anti-cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Michal Kowalczyk, Anna Panasiuk-Kowalczyk, Adam Stadnik, Malgorzata Guz, Marek Cybulski, Witold Jeleniewicz, Andrzej Stepulak, Magdalena Kwiatosz-Muc
Summary: This study aimed to investigate the effects of dexmedetomidine on brain injury during cardiac surgery anesthesia. The results showed that dexmedetomidine can increase the concentrations of MMP-12 and MBP, but have no effects on neurocognitive outcomes postoperatively.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Malgorzata Guz, Witold Jeleniewicz, Marek Cybulski, Joanna Kozicka, Jacek Kurzepa, Agnieszka Madro
Summary: This study investigated the potential use of miRNAs in differentiating between chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), finding that miR-210-3p may serve as a biomarker for distinguishing patients with PDAC from those with CP.
BIOMEDICAL REPORTS
(2021)