Review
Food Science & Technology
Paul C. Turner, Jessica A. Snyder
Summary: The heterogeneous distribution of mycotoxins in food limits the usefulness of food sampling and intake estimates for epidemiological studies, highlighting the importance of validated exposure biomarkers.
Article
Biochemistry & Molecular Biology
Xiangrong Chen, Mohamed F. Abdallah, Charlotte Grootaert, Andreja Rajkovic
Summary: FB1 and AFB1 are common contaminants in staple foods such as maize and can disrupt mitochondrial function and cellular signaling. This study found that exposure to FB1 and AFB1 significantly decreases mitochondrial respiration. However, at sub-toxic exposure levels, mitochondrial respiration is stimulated in response to FB1 and AFB1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Debora Muratori Holanda, Sung Woo Kim
Summary: The occurrence of mycotoxins, especially aflatoxins and Fusarium toxins, poses a challenge to pig production globally. Their toxic effects impair the health and growth of pigs. Effective mycotoxin-detoxifying agents are needed to improve pig health and performance, and enhance the sustainable use of crops.
Article
Environmental Sciences
Xiangrong Chen, Mohamed F. Abdallah, Charlotte Grootaert, Filip Van Nieuwerburgh, Andreja Rajkovic
Summary: This study investigated the combined toxicity of Aflatoxin B1 (AFB1) and fumonisin B1 (FB1) on mitochondrial and glycolytic activity in HepG2 cells. The results showed that the co-exposure, especially at high doses, significantly inhibited mitochondrial respiration. Moreover, RNA transcriptome sequencing revealed differential expression of the p53 signaling pathway and downregulation of genes encoding for Complexes I, II, III, and IV.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Food Science & Technology
Diaodiao Yang, Yongli Ye, Jiadi Sun, Jia-Sheng Wang, Caihong Huang, Xiulan Sun
Summary: This review summarizes the changes in fumonisins and the generation of covert fumonisins during processing. It also investigates the toxicity and determination methods of fumonisins and covert fumonisins, and elucidates the factors affecting fumonisins and their covert forms during processing. The production and analysis of covert fumonisins require further research and improvement.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Hifza Rasheed, Ya Xu, Martin E. Kimanya, Xiaoxi Pan, Zhihua Li, Xiaobo Zou, Candida P. Shirima, Melvin Holmes, Michael N. Routledge, Yun Yun Gong
Summary: Numerous population-based studies have shown a high prevalence of aflatoxin-associated childhood stunting in low-income countries, causing a significant disease burden for children under five. The study estimated DALYs and PAR for aflatoxin-related stunting and the co-occurrence of stunting and underweight, revealing the importance of reducing aflatoxin exposure in high-exposure areas to improve child health outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Ruben A. Chavez, Xianbin Cheng, Tim J. Herrman, Matthew J. Stasiewicz
Summary: Aflatoxin and fumonisin contamination in corn is non-uniform, with single kernel analysis providing better accuracy and performance for classification algorithms compared to bulk sample testing. The study shows the distribution of toxins on individual kernels, with the potential for high throughput screening.
Article
Agriculture, Multidisciplinary
David Kemboi, Gunther Antonissen, Phillis Ochieng, Siska Croubels, Siegrid De Baere, Marie-Louise Scippo, Sheila Okoth, Erastus Kangethe, Johannes Faas, Barbara Doupovec, Johanna Lindahl, James Gathumbi
Summary: The study aimed to investigate the efficacy of bentonite and fumonisin esterase in mitigating the effects of aflatoxins and fumonisins in cattle. The experiments involved measuring mycotoxins, metabolites, and biomarkers related to animal health, productivity, and food safety. The results showed that bentonite effectively decreased AFM1 concentration in milk, while fumonisin esterase converted FUM into less toxic metabolites.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Artur Alves Rodrigues da Silva, Janilson Jose da Silva Jr, Maria Isabel dos Santos Cavalcanti, Dijanah Cota Machado, Paloma Lys Medeiros, Claudio Gabriel Rodrigues
Summary: This study demonstrates that a unitary alphatoxin nanopore can be used to detect and differentiate AFB(1), OTA, and FB1 in aqueous solution. This promising molecular tool allows detection of these mycotoxins at the nanomolar level.
Article
Environmental Sciences
Song Yu, Lianpeng Zou, Jiawei Zhao, Yiping Zhu
Summary: Fumonisins are common contaminants that pose various health risks. This study demonstrates that resveratrol can protect against fumonisin-induced intestinal toxicity by reducing cell damage, apoptosis, and inflammation. It also provides a new strategy for blocking and controlling the toxicity of fumonisins.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Funda Yilmaz Eker, Karlo Muratoglu, Muhsin Ozturk, Bayram Cetin, Serkan Kemal Buyukunal
Summary: In this study, cereal-based foods sold in temporary open-air markets were analyzed for the presence of various mycotoxins using LC-MS/MS. The results showed high levels of contamination, including aflatoxins, ochratoxin, zearalenone, deoxynivalenol, fumonisin, and T-2 toxins. The presence of multiple mycotoxins in grain-based foods poses a significant health risk that needs to be addressed through appropriate regulations and monitoring.
Review
Microbiology
Wenjie Wang, Xinle Liang, Yudong Li, Pinmei Wang, Nancy P. Keller
Summary: Mycotoxin contamination in food is a health hazard and current control methods have limitations. Environmental factors have been tested for their influence on mycotoxin production, revealing a complex regulatory network. Understanding the regulatory mechanisms of different regulators can lead to the development of more efficient methods to inhibit mycotoxin biosynthesis.
Review
Environmental Sciences
Zhicheng Gao, Kangxin Luo, Qiuxiang Zhu, Jinghui Peng, Chang Liu, Xiaoyue Wang, Shoujun Li, Haiyang Zhang
Summary: This review summarizes the occurrence regularity, toxicity, toxic mechanisms, and management strategies of Fumonisin B1 (FB1). FB1 contamination is particularly serious in developing countries, humid and hot regions. FB1 exposure can produce different toxic effects on various systems, including the nervous, respiratory, digestive, and reproductive systems. The mechanism of toxic effects of FB1 is through interfering with sphingolipid de novo biosynthesis and causing oxidative stress and apoptosis. Detection methods for FB1 include lateral flow dipstick technology, enzyme-linked immunosorbent assay, high-performance liquid chromatography, and liquid chromatography-mass spectrometry. Natural plant extracts have been proven to inhibit the toxic effects of FB1 and protect livestock due to their antifungal and antioxidant effects. This review provides comprehensive information on FB1 and can serve as a reference for formulating treatment and management strategies in livestock production.
ENVIRONMENTAL POLLUTION
(2023)
Article
Plant Sciences
Alejandro Ortega-Beltran, Daniel Agbetiameh, Joseph Atehnkeng, Titilayo D. O. Falade, Ranajit Bandyopadhyay
Summary: Results of the study show that treating maize with atoxigenic isolates of A. flavus used in biocontrol formulations did not lead to higher grain fumonisin levels. In fact, most treated maize samples in Nigeria and Ghana had low fumonisin levels considered safe by the European Union, along with lower Fusarium spp. densities compared to untreated maize.
Article
Environmental Sciences
Amany Abdelnaby, Nabila M. Abdelaleem, Elham Elshewy, Ayman H. Mansour, Samar Ibrahim
Summary: The study aimed to establish a sensitive method for determining AFM(1) and OTA using HPLC and assess the efficacy of bentonite, date pit, and chitosan nanoparticles for detoxification from contaminated milk. Results showed that 65.7% of samples contained AFM(1) ranging from 4.5 to 502 ng/L, while 25.7% had OTA ranging from 1.45 to 301 ng/L. Bentonite and date pit demonstrated higher removal efficiency compared to chitosan nanoparticles, with minimal impact on milk's nutritional components.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Jose F. Garcia-Mazcorro, Elvira Garza-Gonzalez, Alicia G. Marroquin-Cardona, Jose L. Tamayo
GASTROENTEROLOGIA Y HEPATOLOGIA
(2015)
Article
Food Science & Technology
Samantha Jardon-Xicotencatl, Roberto Diaz-Torres, Alicia Marroquin-Cardona, Tania Villarreal-Barajas, Abraham Mendez-Albores
Article
Chemistry, Physical
Ana Luisa Barrientos-Velazquez, Alicia Marroquin Cardona, Lian Liu, Timothy Phillips, Youjun Deng
APPLIED CLAY SCIENCE
(2016)
Article
Gastroenterology & Hepatology
Katherine E. Zychowski, Sarah E. Elmore, Kristal A. Rychlik, Hoai J. Ly, Felipe Pierezan, Anitha Isaiah, Jan S. Suchodolski, Aline Rodrigues Hoffmann, Amelia A. Romoser, Timothy D. Phillips
DIGESTIVE DISEASES AND SCIENCES
(2015)
Article
Biotechnology & Applied Microbiology
J. F. Garcia-Mazcorro, M. V. Rodriguez-Herrera, A. G. Marroquin-Cardona, J. R. Kawas
LETTERS IN APPLIED MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Kristal A. Rychlik, Jeremiah R. Secrest, Carmen Lau, Jairus Pulczinski, Misti L. Zamora, Jeann Leal, Rebecca Langley, Louise G. Myatt, Muppala Raju, Richard C. -A. Chang, Yixin Li, Michael C. Golding, Aline Rodrigues-Hoffmann, Mario J. Molina, Renyi Zhang, Natalie M. Johnson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Review
Developmental Biology
Kristal A. Rychlik, Fenna C. M. Sille
BIRTH DEFECTS RESEARCH
(2019)
Article
Entomology
Jose F. Garcia-Mazcorro, Jorge R. Kawas, Alicia G. Marroquin-Cardona
Article
Fisheries
Oscar Daniel Garcia-Perez, Mireya Tapia-Salazar, Martha G. Nieto-Lopez, Julio Cesar Cruz-Valdez, Maribel Maldonado-Muniz, Lucia Marlene Guerrero Guerrero, Lucia Elizabeth Cruz-Suarez, Alicia G. Marroquin-Cardona
AQUACULTURE RESEARCH
(2020)
Article
Food Science & Technology
Anai Zavala-Franco, Geronimo Arambula-Villa, Patricia Ramirez-Noguera, Ana Maria Salazar, Monserrat Sordo, Alicia Marroquin-Cardona, Juan De Dios Figueroa-Cardenas, Abraham Mendez-Albores
Article
Environmental Sciences
Itza Mendoza-Sanchez, Inyang Uwak, Louise Myatt, Allison Van Cleve, Jairus C. Pulczinski, Kristal A. Rychlik, Stephen Sweet, Tara Ramani, Josias Zietsman, Misti Levy Zamora, Kirsten Koehler, Genny Carrillo, Natalie M. Johnson
Summary: The study aimed to quantify maternal PAH exposure in pregnant women in McAllen, Texas, and compared PAH levels in silicone wristbands with those measured using active air-sampling techniques.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Chemistry, Physical
Alicia G. Marroquin-Cardona, Youjun Deng, Jose F. Garcia-Mazcorro, Natalie M. Johnson, Nicolle J. Mitchell, Lili Tang, Jia-Sheng Wang, Roger B. Harvey, Timothy D. Phillips
Summary: The safety of dietary sodium-bentonite as an aflatoxin adsorbent was evaluated in a 3-month rodent study. Results showed that inclusion of 0.25% and 2% sodium-bentonite in the diet did not cause any observable toxicity. However, it did have some effects on serum biochemistry and vitamin and minerals measurements.
CLAYS AND CLAY MINERALS
(2022)
Article
Food Science & Technology
Sara Paola Hernandez-Martinez, Armando Delgado-Cedeno, Yareellys Ramos-Zayas, Moises Armides Franco-Molina, Gerardo Mendez-Zamora, Alicia Guadalupe Marroquin-Cardona, Jorge R. Kawas
Summary: This study compared four clays as adsorbents of AFB(1) and trace inorganic nutrients in an in vitro gastrointestinal model for poultry. The results showed that montmorillonite and beidellite were the most suitable clays for use as adsorbents.
Article
Marine & Freshwater Biology
Mireya Tapia-Salazar, Oscar D. Garcia-Perez, Martha G. Nieto-Lopez, Julio C. Cruz-Valdez, Maribel Maldonado-Muniz, Lucia E. Cruz-Suarez, Alicia G. Marroquin-Cardona
Summary: This study evaluated the impact of a bentonite-based aflatoxin (AF) binder on shrimp growth parameters and enzyme activities. The results showed that the binder protected the shrimp from AF negative effects, but at the highest dose, it increased metabolic enzyme activities.
Article
Toxicology
Sarah E. Elmore, Ramon S. Trevino-Espinosa, Jose F. Garcia-Mazcorro, Patricia Gonzalez-Barranco, Rosa M. Sanchez-Casas, Timothy D. Phillips, Alicia G. Marroquin-Cardona
Summary: Aflatoxins and fumonisins were found in urine samples of healthy volunteers and foods collected near the sampling zone in Monterrey, Mexico. The average concentrations of AFM(1) and FB1 in urine samples were 4.3 pg/mg and 50 pg/mg, with more than half of the samples showing detectable levels of both toxins. Co-exposure to AF and FB was common in the metropolitan area of Monterrey.
TOXICOLOGY REPORTS
(2021)