Article
Multidisciplinary Sciences
Gonggong Lu, Yang Xu, Quanying Liu, Manyu Chen, Huan Sun, Peilei Wang, Xing Li, Yuxiang Wang, Xiang Li, Xuhui Hui, En Luo, Jun Liu, Qing Jiang, Jie Liang, Yujiang Fan, Yong Sun, Xingdong Zhang
Summary: In this study, an instantly fixable and self-adaptive scaffold was engineered to promote cranial reconstruction by calcium chelation and interface integration, while also regulating macrophage M2 polarization and recruiting endogenous stem cells.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Annalisa Martorana, Calogero Fiorica, Fabio Salvatore Palumbo, Salvatore Federico, Gaetano Giammona, Giovanna Pitarresi
Summary: This study developed a drug-loaded 3D nanocomposite scaffold based on polyurethane urea (PUU) using the 3D solvent-casting technique to achieve sustained local delivery and redox-responsive release of doxorubicin, and prevent local bone cancer recurrence. The results demonstrated the stability and resistance of the 3D printed scaffolds over time, as well as their high cytotoxicity on cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Maria-Eirini Grigora, Zoi Terzopoulou, Diana Baciu, Theodore Steriotis, Georgia Charalambopoulou, Eleni Gounari, Dimitrios N. Bikiaris, Dimitrios Tzetzis
Summary: This study investigated the effect of two different types of bioactive coatings on the properties of 3D printed poly(lactic acid)/montmorillonite nanocomposite scaffolds. The scaffolds were coated with ordered mesoporous strontium bioglass (SrBG) and SrBG combined with nanohydroxyapatite (nHA) using a simple dip coating procedure. The coatings improved the hydrophilicity, elastic modulus, and hardness of the scaffolds. Moreover, the coating process enhanced biomineralization and promoted the differentiation of stem cells towards osteoblasts, making it a fast, economical, and effective method for bone tissue engineering applications.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Polymer Science
Mansab Ali Saleemi, Vuanghao Lim
Summary: Polyurethanes (PUs) are versatile polymers with applications in various industries. PUs used in biomedical field and consumer products require antimicrobial properties. This review discusses the incorporation of different antibacterial materials into PU matrices to improve their antimicrobial properties and physicochemical properties.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Textiles
Mohan Prasath Mani, Saravana Kumar Jaganathan
Summary: In this study, novel nanocomposites based on polyurethane, ghee, and propolis were developed using the electrospinning technique. The nanocomposites exhibited smaller fiber diameter, hydrophobic and hydrophilic properties, reduced surface roughness, enhanced thermal stability, improved blood compatibility, and non-toxic behavior. These characteristics make the nanocomposites suitable for bone tissue engineering applications.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Materials Science, Multidisciplinary
Lang Rui, Mao Yang, Deyi Zhu, Wenjia Han, Xugang Dang
Summary: A potential nanocomposite scaffold based on waterborne polyurethane grafted collagen polypeptide/hydroxyapatite (WPU-g-CP/HAp) was successfully synthesized and characterized in terms of its mechanical properties, structural composition, and biodegradation performance, showing promising potential as an ideal bone healing material.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Coatings & Films
Mohamed T. Elabbasy, Fahad D. Algahtani, Hamoud Fahad Alshammari, Lioua Kolsi, Mohamed A. Dkhil, Ghada Abd El-Rahman, M. A. El-Morsy, A. A. Menazea
Summary: Chromic oxide (Cr2O3) demonstrates excellent performance in applications such as glasses, paints, and biomedical applications. In this study, nanocomposites of hydroxyapatite (HAP)/chromium oxide (Cr2O3)/graphene oxide (GO) were constructed to meet specific application requirements. The combination of GO and Cr2O3 with HAP effectively reduced grain agglomeration and increased surface area. The resulting HAP/Cr2O3/GO nanocomposite exhibited a small grain size, macro-porous structure, high antibacterial activity, excellent biocompatibility, and could potentially be used as an implant in biomedical applications.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
William Cardenas-Aguazaco, Bernardo Camacho, Edwin Yesid Gomez-Pachon, Adriana Lorena Lara-Bertrand, Ingrid Silva-Cote
Summary: This study evaluates the potential use of electrospun scaffolds composed of polylactic acid and collagen integrated with hydroxyapatite or amorphous calcium phosphate in bone repair. The results show that the amorphous calcium phosphate scaffold exhibits favorable biocompatibility, promotes cell adhesion and osteocalcin production, and stimulates the production of bone-repair-related growth factors.
Article
Chemistry, Multidisciplinary
Dongying Li, Meigui Chen, Wenmin Guo, Pin Li, Haoyu Wang, Wenhao Ding, Mengqi Li, Yong Xu
Summary: In this study, a hybrid material of graphene oxide and nanohydroxyapatite was successfully constructed using chemical modification and in situ growth methods. This hybrid material addressed the issues of uneven dispersion and poor interface bonding caused by nano-aggregation effects. The composite scaffold exhibited improved strength and bioactivity, with good biomineralization ability in vitro and promotion of cell adhesion and proliferation.
Article
Biophysics
Shujun Cao, Qiujing Li, Shukun Zhang, Kaihua Liu, Yifan Yang, Jingdi Chen
Summary: Bone tissue engineering plays a significant role in bone defect repair and regeneration. This article introduces a low-cost manufacturing method for a new bone repair composite scaffold that shows improved mechanical properties and stability compared to other scaffolds, promoting cell proliferation and bone tissue formation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Mohan Wang, Zheyuan Gu, Beibei Li, Jingyi Zhang, Lu Yang, Xianyu Zheng, Faming Pan, Jiacai He
Summary: This study prepared and characterized chitosan-hydroxyapatite microsponges using a combination of microfluidic emulsion, freezing, and in situ thawing methods. The microsponges showed a porous structure and demonstrated good bioactivity and osteogenic differentiation potential. These microsponges have the potential to be used as bone substitute materials for bone tissue engineering.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Physical
Guannan Zhang, Ying Lu, Jianbo Song, Di Huang, Meiwen An, Weiyi Chen, Peide Han, Xiaohong Yao, Xiangyu Zhang
Summary: A novel multifunctional scaffold material has been developed to inhibit the proliferation of bone tumor cells and promote bone formation through near infrared irradiation, which is of great significance for treating tissue damage after bone tumor resection.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Renato de Moraes, Ana Maria de Guzzi Plepis, Virginia da Conceicao Amaro Martins, Claudio Fernandes Garcia, Ewerton Alexandre Galdeano, Fernanda Latorre Melgaco Maia, Eduardo Gomes Machado, Marcelo de Azevedo e Souza Munhoz, Daniela Vieira Buchaim, Victor Augusto Ramos Fernandes, Rodrigo Alves Beraldo, Rogerio Leone Buchaim, Marcelo Rodrigues da Cunha
Summary: Bone lesions have the ability to regenerate under normal bone metabolism conditions, but scaffolds are needed to assist in the bone regeneration process due to increasing incidence of major traumas and diseases like osteoporosis. This study evaluated the osteoregenerative potential of mineralized collagen and nanohydroxyapatite (nHA) scaffolds combined with elastin in the tibiae of healthy and ovariectomized rats. The results showed that these scaffolds had superior osteogenic potential and promoted new bone formation in rats with normal bone metabolism and with gonadal deficiency, compared to control groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Kun Luo, Pengfei Gao, Weihu Yang, Xiaoyu Lei, Tuck-Whye Wong, Ahmad Fauzi Ismail, Li Wang
Summary: In this study, a 3D porous scaffold was prepared by incorporating citrate functionalized amorphous calcium phosphate into a polytetrahydrofuran based polyurethane scaffold. The obtained scaffold exhibited high porosity, appropriate pore size, and sufficient mechanical strength for cell adhesion and structural support. The scaffold also showed excellent antibacterial properties and biocompatibility, making it a potential candidate for minimally invasive alveolar bone regeneration.
APPLIED MATERIALS TODAY
(2023)
Article
Engineering, Multidisciplinary
Mingzu Du, Jingdi Chen, Kaihua Liu, Huaran Xing, Cui Song
Summary: Hydroxyapatite has significant biological activity, degradability, and osteoconductivity, but also has limitations in terms of mechanical properties, particle size and morphology issues, and brittleness. This article summarizes the challenges and research progress in the fields of dentistry, anti-tumour drug carriers, and orthopaedic repair, providing a theoretical basis for future studies.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Marialaura Clausi, Muhammad Zahid, Amirreza Shayganpour, Ilker S. Bayer
Summary: In this study, paper-like flexible composite phase change materials (PCMs) were developed by hydraulic compression of polyimide foam with PCM film between an aluminum foil and a ceramic composite Parafilm (R). The thermal performance was optimized by adding nano-BN and micro-SiC particles into the Parafilm (R). The results showed that monoliths containing 30 wt% micro-SiC exhibited the best thermal performance, followed by the 60 wt% nano-BN composite. The compression process led to the irreversible collapse of the foam's cellular structure, but the high-k fillers improved impregnation and ensured excellent shape stability and leakage prevention.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)
Article
Engineering, Chemical
Gozde Bayer, Amirreza Shayganpour, Jasim Zia, Ilker S. Bayer
Summary: Edible gels can be used as functional modifiers for biodegradable polymers, showing significant plasticizing effects. These gels, rich in glucose and sugars, contain less water. Carminic acid, added to the gels, acts as a powerful antioxidant and reduces oxygen permeation through the films. The gels also release carminic acid, exhibit color change, and can be used for food spoilage detection.
JOURNAL OF FOOD ENGINEERING
(2022)
Article
Polymer Science
Uttam C. Paul, Gozde Bayer, Silvia Grasselli, Annalisa Malchiodi, Ilker S. Bayer
Summary: Waterborne polyurethane dispersions can be used to produce environmentally friendly and biodegradable plastic films with good mechanical properties and transparency by hybridizing with polyvinylpyrrolidone.
Review
Chemistry, Multidisciplinary
Ilker S. Bayer
Summary: Mucoadhesion is an important field in adhesion science, and understanding and controlling mucoadhesion can lead to life-saving materials and technologies. Mucin plays a crucial role in mucoadhesion processes. This review discusses the role of mucin in wet adhesion under different physiological conditions and highlights advancements in mucoadhesion measurement techniques and new mucoadhesive systems. This knowledge expands our understanding of mucoadhesion in soft materials and contributes to the design and application of new membranes, drugs, pharmaceutical devices, and lubricated surfaces.
ADVANCED MATERIALS INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Ilker S. Bayer
Summary: This article presents recent advances in the understanding and application of fibrin and fibrin-fiber-incorporated biomedical materials for wound healing and tissue repair. It discusses the key roles of fibrinogen and fibrin fibers in tissue regeneration and their functions in wound healing stages. Additionally, it explores the modification of fibrin with next-generation materials to enhance stability and medical efficacy, along with an examination of the mechanical properties of fibrin-based materials.
Article
Engineering, Multidisciplinary
Junyan He, Diab Abueidda, Seid Koric, Iwona Jasiuk
Summary: This paper investigates the application of graph convolutional networks in the deep energy method model for solving the momentum balance equation of linear elastic and hyperelastic materials in three-dimensional space. Numerical examples demonstrate that the proposed method achieves similar accuracy with shorter run time compared to traditional methods. The study also discusses two different spatial gradient computation techniques.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING
(2023)
Review
Chemistry, Analytical
Ilker S. Bayer
Summary: This review discusses the problems encountered in manipulating objects with robotic hands and the applications of microelectromechanical systems (MEMS) sensors. The study found that MEMS platforms offer promising solutions to the control of contact force and approaching motion, enabling robots to effectively detect forces, slippage, and distances to objects.
Article
Engineering, Civil
Junyan He, Shashank Kushwaha, Mahmoud A. Mahrous, Diab Abueidda, Eric Faierson, Iwona Jasiuk
Summary: This study characterizes the size-dependent properties of materials through experimental methods by manufacturing and testing flat dog-bone tensile specimens of different thicknesses. Approximate analytical expressions for material properties values as a function of specimen thickness are provided through curve-fitting to experimental data, creating a phenomenological size-dependent constitutive model. The application of the size-dependent material model is demonstrated through numerical simulations of axial crushing and topology optimization, showing improved performance compared to models that ignore size effects.
THIN-WALLED STRUCTURES
(2023)
Review
Pharmacology & Pharmacy
Ilker S. Bayer
Summary: Polysaccharides are complex molecules with exceptional properties and can be chemically modified. They have increased application in drug encapsulation and release in nanoscale synthesis due to their biocompatibility and biodegradability. This review focuses on studying sustained drug release from nanoscale polysaccharides, particularly drug release kinetics and mathematical modeling. It highlights the importance of modeling in predicting the behavior of specific polysaccharide matrices and reducing experimental trial and error.
Article
Engineering, Multidisciplinary
Junyan He, Seid Koric, Shashank Kushwaha, Jaewan Park, Diab Abueidda, Iwona Jasiuk
Summary: The authors propose a novel deep operator network (DeepONet) with a residual U-Net (ResUNet) as the trunk network to predict highly nonlinear elastic-plastic stress response for complex geometries obtained from topology optimization under variable loads. The network achieves accurate predictions by encoding complex input geometries and parametric loads, and incorporating additional information fusion through element-wise multiplication of the encoded latent space.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Engineering, Mechanical
Mansoureh Rezapourian, Iwona Jasiuk, Mart Saarna, Irina Hussainova
Summary: This study investigates the manufacturability, mechanical responses, and behavior of Ti6Al4V Split-P triply periodic minimal surface (TPMS) structures produced by selective laser melting. The study evaluates the cell morphologies, relative densities, load-bearing capacity, energy absorption, and mechanical properties of the 3D printed Split-P lattices. The results show that the Split-P lattices have a wide range of elastic modulus, yield strength, ultimate strength, load-bearing capacity, energy absorption capacity, and plateau stress. The homogenization analysis reveals isotropy and anisotropy in mechanical properties depending on the lattice and isovalue. Ti6Al4V Split-P lattices with high surface area-to-volume ratio are suitable for bone implants in load-bearing applications.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Article
Instruments & Instrumentation
Siyuan Pang, Iwona Jasiuk
Summary: Reference point indentation (RPI) is a new experimental technique for evaluating bone quality. In this study, two RPI instruments, BioDent and OsteoProbe, were used to investigate the mechanical responses of 3D-printed polymers. The mechanical properties obtained from a tensile test were correlated with RPI parameters. The results showed a strong correlation between the elastic modulus and various RPI parameters for Age 0 polymers, but low correlations for Age 5 polymers. This study demonstrates the potential of RPI in evaluating polymer properties and its applicability in both 3D-printed and aged polymers.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2023)
Article
Materials Science, Multidisciplinary
Mahmoud A. Mahrous, Charul Chadha, Pei L. Robins, Christian Bonney, Kingsley A. Boateng, Marc Meyers, Iwona Jasiuk
Summary: In this study, the microstructure and nanostructure of the equine hoof wall were imaged using micro-computed tomography (mu-CT) and serial block-face scanning electron microscopy (SBF-SEM). The morphology of tubular medullary cavities and the porosity of the hoof wall were quantified. The results provide valuable information for the development of hoof-inspired materials and highlight the influence of different measurement methods on porosity quantification.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Pharmacology & Pharmacy
Fiorenza Rancan, Jana Jurisch, Sabrina Hadam, Annika Vogt, Ulrike Blume-Peytavi, Ilker S. Bayer, Marco Contardi, Christoph Schaudinn
Summary: Bacterial infections pose a constant challenge in wound management, especially with the increasing prevalence of chronic wounds due to an aging population. This study investigated the antimicrobial activity of polyvinylpyrrolidone foils loaded with ciprofloxacin in ex vivo human wounds infected with methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. The treatment effectively countered the infections and their associated effects.
Article
Chemistry, Physical
Benjamin S. Lazarus, Rachel K. Luu, Samuel Ruiz-Perez, Josiane D. V. Barbosa, Iwona Jasiuk, Marc A. Meyers
Summary: Periodic microcomputed tomography scans are used to observe the temporal behavior of the hoof's meso and microstructures during compression, fracture, and relaxation. The study reveals the structural anisotropy of the hoof wall and the behavior of the hollow tubules in different scenarios. Several fracture phenomena, including tubule interfaces, tubule bridging, tubule arresting, and fiber bridging, are elucidated. Relaxation tests demonstrate the recovery of tubule cavities after compression.
