Heterozygous Null Bone Morphogenetic Protein Receptor Type 2 Mutations Promote SRC Kinase-dependent Caveolar Trafficking Defects and Endothelial Dysfunction in Pulmonary Arterial Hypertension

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of Caveolin-1 Is Sufficient to Phenocopy the Behavior of a Disease-Associated Mutant

(2013) Caroline A. Hanson et al.   TRAFFIC

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immune and Inflammatory Cell Involvement in the Pathology of Idiopathic Pulmonary Arterial Hypertension

(2012) Rajkumar Savai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension

(2012) K. Asosingh et al.   BLOOD

Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension

(2012) Eric D. Austin et al.   Circulation-Cardiovascular Genetics

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

(2012) Hikaru Sugimoto et al.   NATURE MEDICINE

Caveolae, caveolins, cavins, and endothelial cell function: new insights

(2012) Grzegorz Sowa   Frontiers in Physiology

Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension

(2011) Roxane Paulin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II

(2011) V. J. Burton et al.   BLOOD

Role for miR-204 in human pulmonary arterial hypertension

(2011) Audrey Courboulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

(2010) V. J. Burton et al.   BLOOD

Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era

(2010) Marc Humbert et al.   CIRCULATION

BMP signaling in vascular development and disease

(2010) Jonathan W. Lowery et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

(2009) Lynda Anderson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo

(2009) A. Reinisch et al.   BLOOD

Caveolae-mediated Internalization of Occludin and Claudin-5 during CCL2-induced Tight Junction Remodeling in Brain Endothelial Cells

(2009) Svetlana M. Stamatovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration

(2009) You-Yang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1−/− mice

(2008) Nikolaos A. Maniatis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Genetic Ablation of the Bmpr2 Gene in Pulmonary Endothelium Is Sufficient to Predispose to Pulmonary Arterial Hypertension

(2008) Kwon-Ho Hong et al.   CIRCULATION

Regulation of transendothelial permeability by Src Kinase

(2008) Guochang Hu et al.   MICROVASCULAR RESEARCH

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells

(2008) A. Vultur et al.   MOLECULAR CANCER THERAPEUTICS

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature

(2007) David B. Frank et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY